I. Summary

SecReT6 ID	144
Strain	Ralstonia eutropha H16
Replicon	chromosome II [Browse all T6SS(s) in this replicon]
Accession	NC_008314
Location	2719224..2755311
Comment
Function	N/A
T6SS Type	Type i; subtype i4a
Bioinformatics investigation has been performed on this T6SS.

II. T6SS components

Component	TssH	TssD	TssL	TssI	TssA	TssB	TssC	TssE	TssF
Number	1	1	1	1	1	1	1	1	1
Component	TssG	TssJ	TssK	TssM
Number	1	0	1	1

III. genome coordinates of the T6SS gene cluster
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Note
1	H16_B2405	2714370..2714726 [-], 357	116696341	putative monooxygenase
2	H16_B2406 (cypX)	2714754..2715878 [-], 1125	116696342	putative cytochrome P450
3	H16_B2407 (acrB10)	2716034..2719210 [-], 3177	116696343	cation/multidrug efflux pump
4	H16_B2408 (acrA10)	2719224..2720498 [-], 1275	116696344	cation/multidrug efflux system, mebrane-fusion component
5	H16_B2409 (acrC10)	2720515..2721786 [-], 1272	116696345	cation/multidrug efflux system outer membrane porin
6	H16_B2410 (acrD)	2721884..2722258 [-], 375	116696346	cation efflux system periplasmic protein
7	H16_B2411	2722544..2722888 [+], 345	116696347	hypothetical protein
8	H16_B2412	2722941..2723147 [-], 207	116696348	hypothetical protein
9	H16_B2413 (rpoE6)	2723190..2723783 [-], 594	116696349	RNA polymerase sigma factor
10	H16_B2414	2723870..2725033 [-], 1164	116696350	hypothetical protein
11	H16_B2415	2725094..2726179 [-], 1086	116696351	hypothetical protein	TssA
12	H16_B2416 (icmF)	2726176..2730294 [-], 4119	116696352	IcmF-like protein	TssM
13	H16_B2417	2730332..2731084 [-], 753	116696353	hypothetical protein	TssL
14	H16_B2418	2731111..2732439 [-], 1329	116696354	hypothetical protein	TssK
15	H16_B2419	2732485..2732988 [-], 504	116696355	hypothetical protein
16	H16_B2420 (gltP4)	2733018..2734472 [-], 1455	116696356	proton/sodium-dicarboxylate symporter
17	H16_B2421 (racX)	2734469..2735191 [-], 723	116696357	aspartate racemase
18	H16_B2422 (gltP3)	2735203..2736537 [-], 1335	116696358	proton/sodium-dicarboxylate symporter
19	H16_B2423	2736534..2737283 [-], 750	116696359	periplasmic solute binding protein
20	H16_B2424	2737527..2737787 [-], 261	116696360	hypothetical protein
21	H16_B2425	2737805..2738191 [-], 387	116696361	hypothetical protein
22	H16_B2426	2738194..2738856 [-], 663	116696362	hypothetical protein
23	H16_B2427	2738915..2740816 [-], 1902	116696363	hypothetical protein	TssI
24	H16_B2428 (clpB2)	2740820..2743540 [-], 2721	116696364	ATP-dependent protease Clp, ATPase subunit	TssH
25	H16_B2429	2743552..2744598 [-], 1047	116696365	quinoprotein dehydrogenase	TssG
26	H16_B2430	2744553..2746328 [-], 1776	116696366	hypothetical protein	TssF
27	H16_B2431	2746321..2746776 [-], 456	116696367	hypothetical protein	TssE
28	H16_B2432	2746789..2747313 [-], 525	116696368	hypothetical protein	TssD
29	H16_B2433	2747374..2748885 [-], 1512	116696369	hypothetical protein	TssC
30	H16_B2434	2748949..2749485 [-], 537	116696370	hypothetical protein	TssB
31	H16_B2435	2750276..2750995 [+], 720	116696371	response regulator
32	H16_B2436	2751281..2751637 [+], 357	116696372	hypothetical protein
33	H16_B2437	2751899..2752792 [+], 894	116696373	LysR family transcriptional regulator
34	H16_B2438	2752996..2754228 [+], 1233	116696374	acyl-CoA transferase/carnitine dehydratase
35	H16_B2439	2754334..2755311 [+], 978	116696375	extra-cytoplasmic solute receptor
36	H16_B2440 (hyuAB)	2755733..2759461 [+], 3729	116696376	hydantoinase/oxoprolinase

 Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.

1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

N/A

N/A

(1) Boyer F et al. (2009). Dissecting the bacterial type VI secretion system by a genome wide in silico analysis: what can be learned from available microbial genomic resources. BMC Genomics. 10:104. [PudMed:19284603]

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