I. Summary
SecReT6 ID155 insolico
StrainEscherichia coli APEC O1
Repliconchromosome [Browse all T6SS(s) in this replicon]
T6SS TypeType i; subtype i1
insolico Bioinformatics investigation has been performed on this T6SS.

II. T6SS components
III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1APECO1_1783 (dkgB)233893..234696 [+], 8041176224892,5-diketo-D-gluconate reductase B 
2APECO1_1782234693..235607 [-], 915117622490LysR family transcriptional regulator 
3APECO1_1781 (yafD)235824..236648 [+], 825117622491hypothetical protein 
4APECO1_1780 (yafE)236726..237496 [+], 771117622492hypothetical protein 
5APECO1_1779 (mltD)237543..238901 [-], 1359117622493membrane-bound lytic murein transglycosylase D 
6APECO1_1778 (gloB)238973..239728 [-], 756117622494hydroxyacylglutathione hydrolase 
7APECO1_1777 (yafS)239744..240484 [+], 741117622495S-adenosyl-L-methionine-dependent methyltransferase 
8APECO1_1776 (rnhA)240481..241059 [-], 579117622496ribonuclease H 
9APECO1_1775 (dnaQ)241004..241744 [+], 741117622497DNA polymerase III subunit epsilon 
10APECO1_1773 (yafT)242282..243067 [+], 786117622499aminopeptidase 
11APECO1_1772 (aec32)243407..243886 [-], 480117622500hypothetical protein  TssD
12APECO1_1771 (aec31)243904..245403 [-], 1500117622501hypothetical protein  TssA
13APECO1_1770 (aec30)245273..248800 [-], 3528117622502hypothetical protein  TssM
14APECO1_1769 (aec29)248820..250262 [-], 1443117622503hypothetical protein  TssA
15APECO1_1768 (aec28)250267..251010 [-], 744117622504hypothetical protein 
16APECO1_1767 (aec27)251007..253766 [-], 2760117622505ATPase  TssH
17APECO1_1766 (aec26)253776..254540 [-], 765117622506hypothetical protein  TssL
18APECO1_1765 (aec25)254545..255891 [-], 1347117622507hypothetical protein  TssK
19APECO1_1764 (aec24)255894..256418 [-], 525117622508hypothetical protein  TssJ
20APECO1_1763 (aec23)256415..257707 [-], 1293117622509hypothetical protein  Fha
21APECO1_1762 (aec22)257712..258761 [-], 1050117622510hypothetical protein  TssG
22APECO1_1761258725..260575 [-], 1851117622511hypothetical protein  TssF
23APECO1_1760 (aec19)260572..260997 [-], 426117622512hypothetical protein  TssE
24APECO1_1759 (aec18)261002..262486 [-], 1485117622513hypothetical protein  TssC
25APECO1_1758 (aec17)262509..263012 [-], 504117622514hypothetical protein  TssB
26APECO1_1757 (aec16)263718..264236 [+], 519117622515hypothetical protein  TssD
27APECO1_1756 (aec15)264457..266439 [+], 1983117622516hypothetical protein  TssI
28APECO1_1755 (aec14)266546..267592 [+], 1047117622517hypothetical protein 
29APECO1_1753267585..269024 [+], 1440117622518hypothetical protein  PAAR
30APECO1_1752 (aec11)268999..269289 [+], 291117622519hypothetical protein 
31APECO1_1751 (yhhI)269826..270311 [+], 486117622520transposase 
32APECO1_1750 (aec8)270540..271043 [+], 504117622521hypothetical protein 
33APECO1_1749 (aec7)271113..271625 [+], 513117622522hypothetical protein 
34APECO1_1748 (yafV)271896..272666 [-], 771117622523hypothetical protein 
35APECO1_1747 (ivy)272820..273293 [+], 474117622524C-lysozyme inhibitor 
36APECO1_1746 (fadE)273336..275780 [-], 2445162317586acyl-CoA dehydrogenase 
37APECO1_1745 (gmhA)275858..276598 [+], 741117622526phosphoheptose isomerase 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

Download FASTA format files
Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

Homology Effector list

Effector identified
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1APECO1_1757(aec16)263718..264236 [+], 519117622515hypothetical protein ECA2866

Download FASTA format files
Proteins        Genes
The information on regulator interaction.

#homolog effector locus tagRegulator wayFunctionRegulate targetDescription
1APECO1_487 (FNR)Transcription regulator+APECO1_1756 (VgrG1)FNR direct regulates vgrG by binding to the promoter regions of vgrG.
(1) Boyer F et al. (2009). Dissecting the bacterial type VI secretion system by a genome wide in silico analysis: what can be learned from available microbial genomic resources. BMC Genomics. 10:104. [PudMed:19284603] in_silico
in_silico This literature contains bioinformatics investigation