I. Summary
SecReT6 ID156 insolico
StrainEscherichia coli APEC O1
Repliconchromosome [Browse all T6SS(s) in this replicon]
T6SS TypeType i; subtype i2
insolico Bioinformatics investigation has been performed on this T6SS.

II. T6SS components
III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1APECO1_3727 (fucU)3107900..3108322 [+], 423117625032L-fucose mutarotase 
2APECO1_3726 (fucR)3108371..3109111 [+], 741117625033FucR family transcriptional regulator 
3APECO1_3725 (ygdE)3109155..3110255 [-], 1101117625034RNA 2'-O-ribose methyltransferase 
4APECO1_37243110248..3110643 [-], 396117625035hypothetical protein 
5APECO1_3723 (gcvA)3110662..3111579 [-], 918117625036DNA-binding transcriptional activator GcvA 
6APECO1_3722 (csdA)3112349..3113554 [+], 1206117625037cysteine sulfinate desulfinase 
7APECO1_3721 (ygdK)3113554..3113997 [+], 444117625038Fe-S metabolism protein 
8APECO1_3720 (ygdL)3114048..3114854 [-], 807117625039hypothetical protein 
9APECO1_3719 (mltA)3114931..3116028 [-], 1098162317572murein transglycosylase A 
10APECO1_37183117169..3117669 [+], 501117625041hypothetical protein  TssB
11APECO1_37173117722..3119266 [+], 1545117625042hypothetical protein  TssC
12APECO1_37163119284..3120621 [+], 1338117625043hypothetical protein  TssK
13APECO1_37153120618..3121283 [+], 666117625044hypothetical protein  TssL
14APECO1_37143121335..3122948 [+], 1614117625045outer membrane protein  TagL
15APECO1_37133123006..3123497 [+], 492117625046hemolysin-coregulated protein  TssD
16APECO1_37123123689..3126334 [+], 2646117625047ATPase  TssH
17APECO1_37113126346..3128826 [+], 2481117625048hypothetical protein  TssI
18APECO1_37103128846..3130012 [+], 1167117625049hypothetical protein  Tle4 (e)
19APECO1_37093130225..3130605 [+], 381117625050hypothetical protein 
20APECO1_37083130580..3131413 [+], 834117625051hypothetical protein  Tli4 (i)
21APECO1_37073131382..3131675 [+], 294117625052hypothetical protein 
22APECO1_37053133547..3136885 [+], 3339117625053hypothetical protein  TssM
23APECO1_37043136943..3137692 [-], 750117625054ISEc12 ATP-binding protein 
24APECO1_37033137704..3139245 [-], 1542117625055transposase for ISEc12 
25APECO1_37023139452..3141089 [+], 1638117625056hypothetical protein  TssA
26APECO1_37013141089..3142672 [+], 1584117625057hypothetical protein  PAAR
27APECO1_37003142672..3143301 [+], 630117625058hypothetical protein 
28APECO1_36993143558..3144001 [+], 444117625059hypothetical protein 
29APECO1_36983144371..3146131 [+], 1761117625060hypothetical protein  TssF
30APECO1_36973146095..3147174 [+], 1080117625061hypothetical protein  TssG
31APECO1_36963147155..3147691 [+], 537117625062hypothetical protein  TssJ
32APECO1_36953147695..3148123 [+], 429117625063hypothetical protein  TssE
33APECO1_36943148123..3149499 [+], 1377117625064hypothetical protein  TssA
34APECO1_36933149801..3150748 [-], 9481176250652-hydroxyacid dehydrogenase 
35APECO1_36923150820..3151416 [-], 597117625066phosphosugar isomerase 
36APECO1_36913151419..3152594 [-], 1176117625067aminotransferase 
37APECO1_36903152594..3154174 [-], 1581117625068PTS system, maltose and glucose-specific IIABC component 
38APECO1_36893154206..3155087 [-], 882117625069antiterminator 
39APECO1_3688 (amiC)3155288..3156631 [-], 1344117625070N-acetylmuramoyl-L-alanine amidase 
40APECO1_3687 (argA)3156863..3158104 [+], 1242117625071N-acetylglutamate synthase 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

Homology Effector list
EC042_4529 , AHW84487

Effector identified
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1APECO1_37133123006..3123497 [+], 492117625046hemolysin-coregulated protein EC042_4529
2APECO1_37103128846..3130012 [+], 1167117625049hypothetical protein AHW84487

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Proteins        Genes

Homology Immunity protein list

Immunity protein identified
#Locus tag(Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1APECO1_37083130580..3131413 [+], 834117625051hypothetical protein AHW84488

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Proteins        Genes
(1) Boyer F et al. (2009). Dissecting the bacterial type VI secretion system by a genome wide in silico analysis: what can be learned from available microbial genomic resources. BMC Genomics. 10:104. [PudMed:19284603] in_silico
in_silico This literature contains bioinformatics investigation