I. Summary
SecReT6 ID199 insolico
StrainAeromonas salmonicida subsp. salmonicida A449
Repliconchromosome [Browse all T6SS(s) in this replicon]
T6SS TypeType i; subtype i1
insolico Bioinformatics investigation has been performed on this T6SS.

II. T6SS components
III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1ASA_2437 (lolA)2599542..2600150 [-], 609145299387outer membrane lipoprotein carrier protein LolA 
2ASA_2438 (ftsK)2600228..2602777 [-], 2550145299388DNA translocase FtsK 
3ASA_2439 (lrp)2602956..2603447 [-], 492145299389leucine-responsive transcriptional regulator 
4ASA_2440 (trxB)2604522..2605472 [+], 951145299390thioredoxin reductase 
5ASA_24412605530..2606777 [+], 1248145299391two-component response transcriptional regulator 
6ASA_24422606880..2607350 [-], 471145299392outer membrane lipoprotein 
7ASA_2443 (aat)2607340..2608077 [+], 738145299393leucyl/phenylalanyl-tRNA--protein transferase 
8ASA_2444 (ate)2608074..2608790 [+], 717145299394arginyl-tRNA-protein transferase 
9ASA_2445 (infA)2608859..2609077 [+], 219145299395translation initiation factor IF-1 
10ASA_2446 (clpA)2609146..2611398 [-], 2253145299396ATP-dependent Clp protease, ATP-binding subunit ClpA  TssH
11ASA_2447 (clpS)2611458..2611775 [-], 318145299397ATP-dependent Clp protease adaptor protein ClpS 
12ASA_2448 (cspD)2612005..2612223 [+], 219145299398cold shock domain-containing protein CspD 
13ASA_2449 (folD)2612334..2613197 [-], 864145299399bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 
14ASA_24532613754..2614005 [-], 252145299400hypothetical protein 
15ASA_2454 (insB)2614056..2614454 [-], 399145299401hypothetical protein 
16ASA_2455 (vgrG/insA)2614444..2615091 [-], 648145299402vgrG/InsA fusion protein  TssI
17ASA_24562615103..2615390 [-], 288145299403hypothetical protein  PAAR
18ASA_24572615682..2617118 [-], 1437145299404hypothetical protein  TssA
19ASA_24592622062..2622667 [-], 606145299405hypothetical protein 
20ASA_24602622667..2624205 [-], 1539145299406type VI secretion system sigma-54 dependent transcriptional regulator 
21ASA_2461 (clpB2)2624208..2626850 [-], 2643145299407type VI secretion system clpB chaperone  TssH
22ASA_24622626872..2627651 [-], 780145299408hypothetical protein  TssL
23ASA_24632627675..2629009 [-], 1335145299409hypothetical protein  TssK
24ASA_24642629012..2629527 [-], 516145299410hypothetical protein  TssJ
25ASA_24652629527..2630750 [-], 1224145299411hypothetical protein  Fha
26ASA_24662630791..2631795 [-], 1005145299412hypothetical protein  TssG
27ASA_24672631759..2633525 [-], 1767145299413hypothetical protein  TssF
28ASA_24682633529..2633960 [-], 432145299414hypothetical protein  TssE
29ASA_24702635484..2635987 [-], 504145299415hypothetical protein  TssB
30ASA_24742638939..2640675 [-], 1737145299416sulfate transporter YchM 
31ASA_24772641790..2642017 [+], 228145299417hypothetical protein 
32ASA_24782642233..2643264 [+], 1032145299418IS630 family transposase 
33ASA_24792643410..2643715 [+], 306145299419hypothetical protein 
34ASA_24802643815..2644201 [+], 387145299420hypothetical protein 
35ASA_24822644419..2645581 [-], 1163145299421IS3 family transposase 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

Homology Effector list

Effector identified
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1ASA_P4G080(vgrG)75519..77561 [-], 2043145301290vgrG protein ABG57133

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Proteins        Genes
(1) Boyer F et al. (2009). Dissecting the bacterial type VI secretion system by a genome wide in silico analysis: what can be learned from available microbial genomic resources. BMC Genomics. 10:104. [PudMed:19284603] in_silico
in_silico This literature contains bioinformatics investigation