I. Summary
SecReT6 ID208 insolico
StrainVibrio cholerae O395
Repliconchromosome I [Browse all T6SS(s) in this replicon]
T6SS TypeType i; subtype i1
insolico Bioinformatics investigation has been performed on this T6SS.

II. T6SS components
III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1VC0395_0008 (rbsB)7129..8013 [-], 885147671798D-ribose transporter subunit RbsB 
2VC0395_0009 (rbsC)8068..9036 [-], 969147672299ribose ABC transporter permease 
3VC0395_0010 (rbsA)9066..10568 [-], 1503147671783D-ribose transporter ATP-binding protein 
4VC0395_0011 (rbsD)10595..11014 [-], 420229259762D-ribose pyranase 
5VC0395_001211298..11558 [+], 261147672208putative lipoprotein 
6VC0395_001311706..12074 [-], 369147671565hypothetical protein  TsiV3 (i)
7VC0395_0014 (vgrG-3)12071..15124 [-], 3054147671421vgrG protein  TssI
8VC0395_001515377..16642 [-], 1266147672179hypothetical protein  TssA
9VC0395_001616690..19716 [-], 3027147671876hypothetical protein  TssM
10VC0395_001719706..20227 [-], 522147672059IcmF-related protein  TssM
11VC0395_001820243..21652 [-], 1410147672276hypothetical protein  TssA
12VC0395_001921662..22345 [-], 684147671784hypothetical protein  VCA0118
13VC0395_002022315..23907 [-], 1593147671674sigma-54 dependent transcriptional regulator  VasH
14VC0395_0021 (clpB-2)23910..26519 [-], 2610147672171clpB protein  TssH
15VC0395_002226545..27318 [-], 774147671772hypothetical protein  TssL
16VC0395_002327321..27800 [-], 480147672311hypothetical protein  TssK
17VC0395_002427752..28657 [-], 906147671947hypothetical protein  TssK
18VC0395_002528664..29140 [-], 477147671491putative lipoprotein  TssJ
19VC0395_002629143..30630 [-], 1488147671976hypothetical protein  Fha
20VC0395_002730633..31586 [-], 954147671686hypothetical protein  TssG
21VC0395_002831613..33382 [-], 1770147672162hypothetical protein  TssF
22VC0395_002933388..33813 [-], 426147671801hypothetical protein  TssE
23VC0395_003033816..35294 [-], 1479147672284hypothetical protein  TssC
24VC0395_003135335..35646 [-], 312147671915hypothetical protein  TssB
25VC0395_003235666..35842 [-], 177147672397hypothetical protein  TssB
26VC0395_003336274..37194 [-], 921147672189hypothetical protein 
27VC0395_003437262..37546 [-], 285147671407hypothetical protein  PAAR
28VC0395_0035 (rluA-2)39332..39997 [+], 666147672092ribosomal large subunit pseudouridine synthase A 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

Homology Effector list
VCA0123 , VCA0017, VCA0285, VCA0118, VCA0018, VCA0020, VC1416, VC1418, ABG57132

Effector identified
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1VC0395_0014(vgrG-3)12071..15124 [-], 3054147671421vgrG protein VCA0123
2VC0395_0116(hcp-1)132421..132939 [-], 519147671643hcp protein VCA0017
3VC0395_0944920229..920900 [-], 672147671773hypothetical protein VCA0285
4VC0395_001921662..22345 [-], 684147671784hypothetical protein VCA0118
5VC0395_0115(vgrG-2)130209..132293 [-], 2085147671987vgrG protein VCA0018
6VC0395_0113126068..129325 [-], 3258147672111hypothetical protein VCA0020
7VC0395_A1026(vgrG-1)1068747..1072034 [+], 3288147673444vgrG protein VC1416
8VC0395_A10281073032..1074957 [+], 1926147673623hypothetical protein VC1418
9VC0395_A1025(hcp-2)1068101..1068619 [+], 519147674396hcp protein ABG57132

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Proteins        Genes

Homology Immunity protein list
VCA0124, VCA0021, VCA0286, VC1419

Immunity protein identified
#Locus tag(Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1VC0395_001311706..12074 [-], 369147671565hypothetical protein VCA0124
2VC0395_0112125339..126067 [-], 729147671998hypothetical protein VCA0021
3VC0395_0943919877..920227 [-], 351147672379hypothetical protein VCA0286
4VC0395_A10291074954..1075697 [+], 744147673058hypothetical protein VC1419

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Proteins        Genes
(1) Bernard CS et al. (2011). Regulation of type VI secretion gene clusters by sigma54 and cognate enhancer binding proteins. J Bacteriol. 193(9):2158-67. [PudMed:21378190] experimental
experimental This literature contains experimental investigation