I. Summary

SecReT6 ID	213
Strain	Klebsiella pneumoniae subsp. pneumoniae MGH 78578
Replicon	chromosome [Browse all T6SS(s) in this replicon]
Accession	NC_009648
Location	1483578..1514647
Comment
Function	N/A
T6SS Type	Type i; subtype i2
Bioinformatics investigation has been performed on this T6SS.

II. T6SS components

Component	TssH	TssD	TssL	TssI	TssA	TssB	TssC	TssE	TssF
Number	1	1	1	1	1	1	1	0	1
Component	TssG	TssJ	TssK	TssM
Number	0	0	1	1

III. genome coordinates of the T6SS gene cluster
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Note
1	KPN_01318	1478632..1479546 [-], 915	152969871	LysR family transcriptional regulator
2	KPN_01319	1479689..1480423 [+], 735	152969872	7-alpha-hydroxysteroid dehydrogenase
3	KPN_01320	1480640..1482172 [+], 1533	152969873	metal-dependent phosphohydrolase
4	KPN_01321	1482371..1482919 [-], 549	152969874	putative intracellular protease/amidase
5	KPN_01322	1483578..1484069 [+], 492	152969875	hypothetical protein	TssB
6	KPN_01323	1484106..1485656 [+], 1551	152969876	hypothetical protein	TssC
7	KPN_01324	1485666..1487009 [+], 1344	152969877	hypothetical protein	TssK
8	KPN_01325	1487006..1487695 [+], 690	152969878	hypothetical protein	TssL
9	KPN_01326	1487692..1489398 [+], 1707	152969879	putative outer membrane protein	TagL
10	KPN_01327	1489403..1489894 [+], 492	152969880	hypothetical protein	TssD
11	KPN_01328	1490213..1492813 [+], 2601	152969881	putative protease	TssH
12	KPN_01329	1492806..1495325 [+], 2520	152969882	hypothetical protein	TssI
13	KPN_01330	1495318..1496529 [+], 1212	152969883	hypothetical protein
14	KPN_01331	1496534..1496938 [+], 405	152969884	hypothetical protein
15	KPN_01332	1496928..1497029 [+], 102	152969885	hypothetical protein
16	KPN_01333	1497333..1497584 [+], 252	152969886	hypothetical protein
17	KPN_01334	1497730..1499490 [+], 1761	152969887	putative membrane proteins
18	KPN_01335	1499487..1499747 [+], 261	152969888	hypothetical protein
19	KPN_01336	1499734..1500501 [+], 768	152969889	hypothetical protein
20	KPN_01337	1501395..1501784 [+], 390	152969890	putative transposase-related protein
21	KPN_01338	1502017..1502493 [+], 477	152969891	putative transposase-related protein
22	KPN_01339	1502858..1503199 [+], 342	152969892	maltose transport system permease
23	KPN_01340	1503379..1503513 [+], 135	152969893	hypothetical protein
24	KPN_01341	1503939..1505147 [+], 1209	152969894	putative structural protein
25	KPN_01342	1505225..1508599 [+], 3375	152969895	hypothetical protein	TssM
26	KPN_01343	1508599..1510197 [+], 1599	152969896	hypothetical protein	TssA
27	KPN_01344	1510228..1511283 [+], 1056	152969897	hypothetical protein	PAAR
28	KPN_01345	1511280..1511750 [+], 471	152969898	hypothetical protein
29	KPN_01346	1511844..1512812 [-], 969	152969899	putative transposase, IS4
30	KPN_01347	1512893..1514647 [+], 1755	152969900	hypothetical protein	TssF
31	KPN_01348	1516265..1516324 [-], 60	152969901	hypothetical protein
32	KPN_01349	1516455..1516838 [+], 384	152969902	hypothetical protein
33	KPN_01350	1516905..1517618 [-], 714	152969903	oxidoreductase
34	KPN_01351	1517692..1518285 [+], 594	152969904	putative regulatory protein TetR
35	KPN_01352 (yghA)	1518290..1519045 [-], 756	152969905	oxidoreductase

 Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.

1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

Homology Effector list

EC042_4529

Effector identified
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Homolog
1	KPN_01327	1489403..1489894 [+], 492	152969880	hypothetical protein	EC042_4529

Download FASTA format files

Proteins        Genes

N/A

(1) Sarris PF et al. (2011). Distribution of the putative type VI secretion system core genes in Klebsiella spp. Infect Genet Evol. 11(1):157-66. [PudMed:20932940]

This literature contains bioinformatics investigation