I. Summary
SecReT6 ID225 experimental
StrainYersinia pseudotuberculosis IP 31758
Repliconchromosome [Browse all T6SS(s) in this replicon]
CommentT6SS-4 promotes Y. pseudotuberculosis survival in high osmolarity conditions and resistance to deoxycholate
T6SS TypeType i; subtype i3
experimental Experimental investigation has been performed on this T6SS.

II. T6SS components
III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1YpsIP31758_3419 (rapA)3847096..3850002 [+], 2907153949731ATP-dependent helicase HepA 
2YpsIP31758_34203850258..3850611 [-], 354153948883hypothetical protein 
3YpsIP31758_34213850633..3854127 [-], 3495153949294hypothetical protein  TssM
4YpsIP31758_34223854136..3855746 [-], 1611153950101hypothetical protein  TssL
5YpsIP31758_34233855743..3857098 [-], 1356153950497hypothetical protein  TssK
6YpsIP31758_34243857218..3857709 [-], 492153948671lipoprotein  TssJ
7YpsIP31758_34253857702..3858067 [-], 366153948858hypothetical protein  PAAR
8YpsIP31758_34263858073..3858690 [-], 618153947713hypothetical protein 
9YpsIP31758_34273858683..3859786 [-], 1104153948573pentapeptide repeat-containing protein 
10YpsIP31758_34283859812..3862031 [-], 2220153950018pentapeptide repeat-containing protein 
11YpsIP31758_34293862044..3864392 [-], 2349153947514Rhs element Vgr protein  TssI
12YpsIP31758_34303864496..3867099 [-], 2604153949405AAA ATPase  TssH
13YpsIP31758_34313867102..3868085 [-], 984153948961hypothetical protein  TssG
14YpsIP31758_34323868078..3869922 [-], 1845153948697hypothetical protein  TssF
15YpsIP31758_34333869955..3870398 [-], 444153948252hypothetical protein  TssE
16YpsIP31758_34343870472..3870990 [-], 519153948599hypothetical protein  TssD
17YpsIP31758_34353871153..3872655 [-], 1503153949071hypothetical protein  TssC
18YpsIP31758_34363872664..3873224 [-], 561153948157hypothetical protein  TssB
19YpsIP31758_34373873235..3874248 [-], 1014153948721ImpA domain-containing protein  TssA
20YpsIP31758_34383874578..3875321 [+], 744153946848hypothetical protein 
21YpsIP31758_3439 (rluA)3876544..3877164 [+], 621153948334ribosomal large subunit pseudouridine synthase A 
22YpsIP31758_3440 (djlA)3877481..3878314 [-], 834153950401Dna-J like membrane chaperone protein 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

Homology Effector list
YPK_3558 , YPK_3563

Effector identified
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1YpsIP31758_34293862044..3864392 [-], 2349153947514Rhs element Vgr protein YPK_3558
2YpsIP31758_34343870472..3870990 [-], 519153948599hypothetical protein YPK_3563

Download FASTA format files
Proteins        Genes
Regulatory element identified
OmpR (YpsIP31758_3980)ActivatorPMID: 23840509

lptD (YpsIP31758_3441)ActivatorPMID: 23840509

(1) Gueguen E et al. (2013). Expression of a Yersinia pseudotuberculosis Type VI Secretion System Is Responsive to Envelope Stresses through the OmpR Transcriptional Activator. PLoS One. 8(6):e66615. [PudMed:23840509] experimental
experimental This literature contains experimental investigation