SecReT6
I. Summary
SecReT6 ID225 experimental
StrainYersinia pseudotuberculosis IP 31758
Repliconchromosome [Browse all T6SS(s) in this replicon]
AccessionNC_009708
Location3850633..3874248
CommentT6SS-4 promotes Y. pseudotuberculosis survival in high osmolarity conditions and resistance to deoxycholate
FunctionN/A
T6SS TypeType i; subtype i3
experimental Experimental investigation has been performed on this T6SS.

II. T6SS components
ComponentTssHTssDTssLTssITssATssBTssCTssETssF
Number111111111
ComponentTssGTssJTssKTssM
Number1111
III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1YPSIP31758_RS18425 (rapA)3847096..3850002 [+], 2907499505079RNA polymerase-associated protein RapA 
2YPSIP31758_RS184303850258..3850611 [-], 354488139260hypothetical protein 
3YPSIP31758_RS18435 (tssM)3850633..3854074 [-], 3442pseudogenetype VI secretion system membrane subunit TssM 
4YPSIP31758_RS184403854136..3855746 [-], 1611499505078type IVB secretion system protein IcmH/DotU 
5YPSIP31758_RS18445 (tssK)3855743..3857098 [-], 1356488139262type VI secretion system baseplate subunit TssK 
6YPSIP31758_RS18450 (tssJ)3857218..3857709 [-], 492499505077type VI secretion system lipoprotein TssJ 
7YPSIP31758_RS184553857702..3858067 [-], 366488143529DUF4150 domain-containing protein 
8YPSIP31758_RS184603858073..3858690 [-], 618488139265DUF3540 domain-containing protein 
9YPSIP31758_RS184653858683..3859786 [-], 1104488143531pentapeptide repeat-containing protein 
10YPSIP31758_RS184703859812..3862031 [-], 2220488152879pentapeptide repeat-containing protein 
11YPSIP31758_RS18475 (vgrG)3862044..3864392 [-], 2349501054164type VI secretion system tip protein VgrG 
12YPSIP31758_RS18480 (tssH)3864496..3867084 [-], 2589488139267type VI secretion system ATPase TssH 
13YPSIP31758_RS18485 (tssG)3867102..3868085 [-], 984501054165type VI secretion system baseplate subunit TssG 
14YPSIP31758_RS18490 (tssF)3868078..3869922 [-], 1845499505074type VI secretion system baseplate subunit TssF 
15YPSIP31758_RS184953869955..3870398 [-], 444488139270type VI secretion system baseplate subunit TssE 
16YPSIP31758_RS185003870472..3870990 [-], 519488139271type VI secretion system tube protein Hcp 
17YPSIP31758_RS18505 (tssC)3871153..3872655 [-], 1503488139272type VI secretion system contractile sheath large subunit 
18YPSIP31758_RS18510 (tssB)3872664..3873224 [-], 561488139273type VI secretion system contractile sheath small subunit 
19YPSIP31758_RS185153873235..3874248 [-], 1014488139274ImpA family type VI secretion system protein 
20YPSIP31758_RS185203874578..3875321 [+], 744488143539hexameric transcriptional regulator RovC 
21YPSIP31758_RS18525 (rluA)3876544..3877164 [+], 621488139277bifunctional tRNA pseudouridine(32) synthase/23S rRNA pseudouridine(746) synthase RluA 
22YPSIP31758_RS18530 (djlA)3877481..3878314 [-], 834499505073co-chaperone DjlA 
 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.
 






2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.
 






3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.
 







Homology Effector list
YPK_3558 , YPK_3563

Effector identified
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog

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Proteins        Genes
N/A
Regulatory element identified
OmpR
RegulatorDescriptionReference
OmpR (YpsIP31758_3980)ActivatorPMID: 23840509

lptD
RegulatorDescriptionReference
lptD (YpsIP31758_3441)ActivatorPMID: 23840509

(1) Gueguen E et al. (2013). Expression of a Yersinia pseudotuberculosis Type VI Secretion System Is Responsive to Envelope Stresses through the OmpR Transcriptional Activator. PLoS One. 8(6):e66615. [PudMed:23840509] experimental
 
experimental This literature contains experimental investigation