I. Summary
SecReT6 ID256 insolico
StrainYersinia pseudotuberculosis YPIII
Repliconchromosome [Browse all T6SS(s) in this replicon]
T6SS TypeType i; subtype i1
insolico Bioinformatics investigation has been performed on this T6SS.

II. T6SS components
III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1YPK_0379413738..414100 [+], 363170022632glycosidase 
2YPK_0380414088..415197 [+], 1110170022633maltose/maltodextrin transporter ATP-binding protein 
3YPK_0381 (lamB)415268..416539 [+], 1272170022634maltoporin 
4YPK_0382416780..417691 [+], 912170022635maltose regulon periplasmic protein 
5YPK_0383418030..418440 [+], 411170022636hypothetical protein 
6YPK_0384418431..418649 [+], 219170022637hypothetical protein 
7YPK_0385418592..419110 [-], 519170022638Hcp1 family type VI secretion system effector  TssD
8YPK_0386419634..420131 [+], 498170022639type VI secretion protein  TssB
9YPK_0387420199..421680 [+], 1482170022640EvpB family type VI secretion protein  TssC
10YPK_0388421687..422127 [+], 441170022641type VI secretion system lysozyme-like protein  TssE
11YPK_0389422127..423947 [+], 1821170022642type VI secretion protein  TssF
12YPK_0390423911..424981 [+], 1071170022643type VI secretion protein  TssG
13YPK_0391425107..426423 [+], 1317170022644FHA domain-containing protein  Fha
14YPK_0392426423..426968 [+], 546170022645putative lipoprotein  TssJ
15YPK_0393426971..428317 [+], 1347170022646type VI secretion protein  TssK
16YPK_0394428317..429084 [+], 768170022647hypothetical protein  TssL
17YPK_0395429095..431698 [+], 2604170022648type VI secretion ATPase  TssH
18YPK_0396431695..432492 [+], 798170022649Fis family transcriptional regulator 
19YPK_0397432489..433175 [+], 687170022650hypothetical protein 
20YPK_0398433181..434569 [+], 1389170022651type VI secretion-associated protein  TssA
21YPK_0399434601..438134 [+], 3534170022652type VI secretion protein IcmF  TssM
22YPK_0400438259..439566 [+], 1308170022653ImpA domain-containing protein  TssA
23YPK_0401439588..441810 [+], 2223170022654ImpA family type VI secretion-associated protein  TssI
24YPK_0402441816..442274 [+], 459170022655hypothetical protein 
25YPK_0403442267..446439 [+], 4173170022656YD repeat-containing protein  PAAR
26YPK_0404446442..446861 [+], 420170022657hypothetical protein 
27YPK_0405447145..447390 [+], 246170022658hypothetical protein 
28YPK_0406447390..447878 [+], 489170022659putative cytoplasmic protein 
29YPK_0407447924..448286 [-], 363170022660HSP20-like protein 
30YPK_0408448319..448594 [+], 276170022661hypothetical protein 
31YPK_0409448579..448686 [+], 108170022662hypothetical protein 
32YPK_0410448646..452215 [+], 3570170022663YD repeat-containing protein 
33YPK_0411452212..452493 [+], 282170022664hypothetical protein 
34YPK_0412452695..452916 [+], 222170022665putative rhs accessory genetic element  TssI
35YPK_0413453206..454105 [-], 900170022666xylose isomerase domain-containing protein 
36YPK_0414454102..455232 [-], 1131170022667oxidoreductase domain-containing protein 
37YPK_0415455502..456368 [+], 867170022668AraC family transcriptional regulator 
38YPK_0416456528..457031 [-], 504170022669RbsD or FucU transporter 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

Homology Effector list

Effector identified
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1YPK_0385418592..419110 [-], 519170022638Hcp1 family type VI secretion system effector ECA2866

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Proteins        Genes
(1) Zhang W et al. (2012). A type VI secretion system regulated by OmpR in Yersinia pseudotuberculosis functions to maintain intracellular pH homeostasis. Environ Microbiol. 15(2):557-69. [PudMed:23094603] experimental
(2) Zhang W et al. (2011). Modulation of a thermoregulated type VI secretion system by AHL-dependent quorum sensing in Yersinia pseudotuberculosis. Arch Microbiol. 193(5):351-63. [PudMed:21298257]
experimental This literature contains experimental investigation