SecReT6
I. Summary
SecReT6 ID256 insolico
StrainYersinia pseudotuberculosis YPIII
Repliconchromosome [Browse all T6SS(s) in this replicon]
AccessionNC_010465
Location418592..452916
Comment
FunctionN/A
T6SS TypeType i; subtype i1
insolico Bioinformatics investigation has been performed on this T6SS.

II. T6SS components
ComponentTssHTssDTssLTssITssATssBTssCTssETssF
Number111221111
ComponentTssGTssJTssKTssM
Number1111
III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1YPK_RS01905413857..414084 [+], 228756143920hypothetical protein 
2YPK_RS01910 (malK)414088..415197 [+], 1110488140883maltose/maltodextrin ABC transporter ATP-binding protein MalK 
3YPK_RS01915415268..416539 [+], 1272488140884maltoporin 
4YPK_RS01920 (malM)416780..417691 [+], 912488140885maltose operon protein MalM 
5YPK_RS01925418162..418440 [+], 279752490015hypothetical protein 
6YPK_RS01930418592..419110 [-], 519488140889Hcp family type VI secretion system effector 
7YPK_RS01935 (tssB)419634..420131 [+], 498488140890type VI secretion system contractile sheath small subunit 
8YPK_RS01940 (tssC)420199..421680 [+], 1482488159408type VI secretion system contractile sheath large subunit 
9YPK_RS01945 (tssE)421687..422127 [+], 441488140892type VI secretion system baseplate subunit TssE 
10YPK_RS01950 (tssF)422127..423947 [+], 1821499506561type VI secretion system baseplate subunit TssF 
11YPK_RS01955 (tssG)423911..424981 [+], 1071501260433type VI secretion system baseplate subunit TssG 
12YPK_RS01960 (tagH)425107..426423 [+], 1317501260434type VI secretion system-associated FHA domain protein TagH 
13YPK_RS01965 (tssJ)426423..426968 [+], 546501052767type VI secretion system lipoprotein TssJ 
14YPK_RS01970 (tssK)426971..428317 [+], 1347488140897type VI secretion system baseplate subunit TssK 
15YPK_RS01975428317..429084 [+], 768488140898type IVB secretion system protein IcmH/DotU 
16YPK_RS01980 (tssH)429095..431698 [+], 2604501260435type VI secretion system ATPase TssH 
17YPK_RS01985431695..432492 [+], 798488140900Fis family transcriptional regulator 
18YPK_RS01990 (tagO)432489..433175 [+], 687501260436type VI secretion system-associated protein TagO 
19YPK_RS01995 (tssA)433181..434569 [+], 1389501260437type VI secretion system protein TssA 
20YPK_RS02000 (tssM)434601..438134 [+], 3534501052768type VI secretion system membrane subunit TssM 
21YPK_RS23295438259..439566 [+], 1308501260438type VI secretion system ImpA family N-terminal domain-containing protein 
22YPK_RS02010439588..441810 [+], 2223501260439type VI secretion system tip protein VgrG 
23YPK_RS02015441816..442274 [+], 459488142175DcrB-related protein 
24YPK_RS02020442267..446142 [+], 3876pseudogenePAAR/RHS domain-containing protein 
25YPK_RS21475446442..446861 [+], 420501260441hypothetical protein 
26YPK_RS02035447145..447390 [+], 246501260442hypothetical protein 
27YPK_RS02040447390..447878 [+], 489501260443immunity 26/phosphotriesterase HocA family protein 
28YPK_RS21645447924..448286 [-], 363501260444SymE family type I addiction module toxin 
29YPK_RS02050448283..448372 [-], 90pseudogenetype I addiction module toxin, SymE family 
30YPK_RS22990448361..448450 [+], 90pseudogenehypothetical protein 
31YPK_RS22995448570..448644 [+], 75pseudogenehypothetical protein 
32YPK_RS02055448646..452215 [+], 3570pseudogeneRHS repeat protein 
33YPK_RS02060452212..452493 [+], 282499506550hypothetical protein 
34YPK_RS02065452695..452916 [+], 222501260448type IV secretion protein Rhs 
35YPK_RS21650452917..453186 [-], 2701169641666SymE family type I addiction module toxin 
36YPK_RS02070453206..454105 [-], 900488138816sugar phosphate isomerase/epimerase 
37YPK_RS02075454102..455232 [-], 1131488138817Gfo/Idh/MocA family oxidoreductase 
38YPK_RS02080455502..456368 [+], 867501260449helix-turn-helix transcriptional regulator 
39YPK_RS02085 (rbsD)456528..457031 [-], 504499506547D-ribose pyranase 
 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.
 






2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.
 






3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.
 







Homology Effector list
ECA2866

Effector identified
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog

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Proteins        Genes
N/A
(1) Zhang W et al. (2012). A type VI secretion system regulated by OmpR in Yersinia pseudotuberculosis functions to maintain intracellular pH homeostasis. Environ Microbiol. 15(2):557-69. [PudMed:23094603] experimental
(2) Zhang W et al. (2011). Modulation of a thermoregulated type VI secretion system by AHL-dependent quorum sensing in Yersinia pseudotuberculosis. Arch Microbiol. 193(5):351-63. [PudMed:21298257]
 
experimental This literature contains experimental investigation