I. Summary
SecReT6 ID257 insolico
StrainYersinia pseudotuberculosis YPIII
Repliconchromosome [Browse all T6SS(s) in this replicon]
T6SS TypeType i; subtype i2
insolico Bioinformatics investigation has been performed on this T6SS.

II. T6SS components
III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1YPK_RS03975903021..903671 [+], 651488144694CPBP family intramembrane metalloprotease 
2YPK_RS03980904122..904517 [+], 396488144692lipoprotein 
3YPK_RS03985904585..904926 [+], 342pseudogeneIS1 family transposase 
4YPK_RS23335905419..905574 [+], 156501260615hypothetical protein 
5YPK_RS04000 (tssB)906784..907284 [+], 501488141806type VI secretion system contractile sheath small subunit  TssB
6YPK_RS04005 (tssC)907327..908877 [+], 1551752489932type VI secretion system contractile sheath large subunit 
7YPK_RS04010 (tssK)908889..910241 [+], 1353499505437type VI secretion system baseplate subunit TssK  TssK
8YPK_RS04015910238..910924 [+], 687501260617type VI secretion system protein TssL, short form  TssL
9YPK_RS04020910924..912660 [+], 1737501260618OmpA family protein  TagL
10YPK_RS04025912664..913155 [+], 492488138806Hcp family type VI secretion system effector  TssD
11YPK_RS04030 (tssH)913543..916185 [+], 2643501260619type VI secretion system ATPase TssH  TssH
12YPK_RS04035916188..918536 [+], 2349501260620type VI secretion system tip protein VgrG  TssI
13YPK_RS04040918552..920849 [+], 2298501260621M23 family metallopeptidase 
14YPK_RS04045920836..921603 [+], 768488138800hypothetical protein 
15YPK_RS22775921699..922272 [+], 574pseudogeneIS1 family transposase 
16YPK_RS21790922937..923514 [+], 578pseudogeneDUF2345 domain-containing protein 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

Homology Effector list

Effector identified
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog

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Proteins        Genes
(1) Zhang W et al. (2012). A type VI secretion system regulated by OmpR in Yersinia pseudotuberculosis functions to maintain intracellular pH homeostasis. Environ Microbiol. 15(2):557-69. [PudMed:23094603] experimental
(2) Zhang W et al. (2011). Modulation of a thermoregulated type VI secretion system by AHL-dependent quorum sensing in Yersinia pseudotuberculosis. Arch Microbiol. 193(5):351-63. [PudMed:21298257]
experimental This literature contains experimental investigation