I. Summary

SecReT6 ID	257
Strain	Yersinia pseudotuberculosis YPIII
Replicon	chromosome [Browse all T6SS(s) in this replicon]
Accession	NC_010465
Location	906784..918536
Comment
Function	N/A
T6SS Type	Type i; subtype i2
Bioinformatics investigation has been performed on this T6SS.

II. T6SS components

Component	TssH	TssD	TssL	TssI	TssA	TssB	TssC	TssE	TssF
Number	1	1	1	1	0	1	1	0	0
Component	TssG	TssJ	TssK	TssM
Number	0	0	1	0

III. genome coordinates of the T6SS gene cluster
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Note
1	YPK_RS03975	903021..903671 [+], 651	488144694	CPBP family intramembrane metalloprotease
2	YPK_RS03980	904122..904517 [+], 396	488144692	lipoprotein
3	YPK_RS03985	904585..904926 [+], 342	pseudogene	IS1 family transposase
4	YPK_RS23335	905419..905574 [+], 156	501260615	hypothetical protein
5	YPK_RS04000 (tssB)	906784..907284 [+], 501	488141806	type VI secretion system contractile sheath small subunit	TssB
6	YPK_RS04005 (tssC)	907327..908877 [+], 1551	752489932	type VI secretion system contractile sheath large subunit
7	YPK_RS04010 (tssK)	908889..910241 [+], 1353	499505437	type VI secretion system baseplate subunit TssK	TssK
8	YPK_RS04015	910238..910924 [+], 687	501260617	type VI secretion system protein TssL, short form	TssL
9	YPK_RS04020	910924..912660 [+], 1737	501260618	OmpA family protein	TagL
10	YPK_RS04025	912664..913155 [+], 492	488138806	Hcp family type VI secretion system effector	TssD
11	YPK_RS04030 (tssH)	913543..916185 [+], 2643	501260619	type VI secretion system ATPase TssH	TssH
12	YPK_RS04035	916188..918536 [+], 2349	501260620	type VI secretion system tip protein VgrG	TssI
13	YPK_RS04040	918552..920849 [+], 2298	501260621	M23 family metallopeptidase
14	YPK_RS04045	920836..921603 [+], 768	488138800	hypothetical protein
15	YPK_RS22775	921699..922272 [+], 574	pseudogene	IS1 family transposase
16	YPK_RS21790	922937..923514 [+], 578	pseudogene	DUF2345 domain-containing protein

 Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.

1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

Homology Effector list

EC042_4529

Effector identified
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Homolog

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Proteins        Genes

N/A

(1) Zhang W et al. (2012). A type VI secretion system regulated by OmpR in Yersinia pseudotuberculosis functions to maintain intracellular pH homeostasis. Environ Microbiol. 15(2):557-69. [PudMed:23094603]

(2) Zhang W et al. (2011). Modulation of a thermoregulated type VI secretion system by AHL-dependent quorum sensing in Yersinia pseudotuberculosis. Arch Microbiol. 193(5):351-63. [PudMed:21298257]

This literature contains experimental investigation