I. Summary

SecReT6 ID	257
Strain	Yersinia pseudotuberculosis YPIII
Replicon	chromosome [Browse all T6SS(s) in this replicon]
Accession	NC_010465
Location	906784..918536
Comment
Function	N/A
T6SS Type	Type i; subtype i2
Bioinformatics investigation has been performed on this T6SS.

II. T6SS components

Component	TssH	TssD	TssL	TssI	TssA	TssB	TssC	TssE	TssF
Number	1	1	1	1	0	1	1	0	0
Component	TssG	TssJ	TssK	TssM
Number	0	0	1	0

III. genome coordinates of the T6SS gene cluster
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Note
1	YPK_0793	903021..903671 [+], 651	170023042	abortive infection protein
2	YPK_0794	904188..904517 [+], 330	170023043	lipoprotein
3	YPK_0795	904585..904848 [+], 264	170023044	insertion element protein
4	YPK_0796	905005..905376 [+], 372	170023045	hypothetical protein
5	YPK_0797	905419..905574 [+], 156	170023046	hypothetical protein
6	YPK_0798	906784..907284 [+], 501	170023047	type VI secretion protein	TssB
7	YPK_0799	907333..908877 [+], 1545	170023048	EvpB family type VI secretion protein	TssC
8	YPK_0800	908889..910241 [+], 1353	170023049	type VI secretion protein	TssK
9	YPK_0801	910238..910924 [+], 687	170023050	hypothetical protein	TssL
10	YPK_0802	910924..912660 [+], 1737	170023051	OmpA/MotB domain-containing protein	TagL
11	YPK_0803	912664..913155 [+], 492	170023052	Hcp1 family type VI secretion system effector	TssD
12	YPK_0804	913543..916185 [+], 2643	170023053	type VI secretion ATPase	TssH
13	YPK_0805	916188..918536 [+], 2349	170023054	ImpA family type VI secretion-associated protein	TssI
14	YPK_0806	918552..920849 [+], 2298	170023055	peptidase M23B
15	YPK_0807	920836..921603 [+], 768	170023056	hypothetical protein
16	YPK_0808	921699..921974 [+], 276	170023057	insertion element protein
17	YPK_0809	922895..923407 [+], 513	170023058	hypothetical protein

 Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.

1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

Homology Effector list

EC042_4529

Effector identified
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Homolog
1	YPK_0803	912664..913155 [+], 492	170023052	Hcp1 family type VI secretion system effector	EC042_4529

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Proteins        Genes

N/A

(1) Zhang W et al. (2012). A type VI secretion system regulated by OmpR in Yersinia pseudotuberculosis functions to maintain intracellular pH homeostasis. Environ Microbiol. 15(2):557-69. [PudMed:23094603]

(2) Zhang W et al. (2011). Modulation of a thermoregulated type VI secretion system by AHL-dependent quorum sensing in Yersinia pseudotuberculosis. Arch Microbiol. 193(5):351-63. [PudMed:21298257]

This literature contains experimental investigation