I. Summary

SecReT6 ID	264
Strain	Burkholderia cenocepacia MC0-3
Replicon	chromosome I [Browse all T6SS(s) in this replicon]
Accession	NC_010508
Location	466432..501433
Comment
Function	N/A
T6SS Type	Type i; subtype i4b
Bioinformatics investigation has been performed on this T6SS.

II. T6SS components

Component	TssH	TssD	TssL	TssI	TssA	TssB	TssC	TssE	TssF
Number	1	1	1	1	1	1	1	1	1
Component	TssG	TssJ	TssK	TssM
Number	1	1	1	1

III. genome coordinates of the T6SS gene cluster
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Note
1	Bcenmc03_0430	462502..463572 [-], 1071	170731783	helix-turn-helix domain-containing protein
2	Bcenmc03_0431	463579..464247 [-], 669	170731784	hypothetical protein
3	Bcenmc03_0432	464962..465165 [+], 204	170731785	hypothetical protein
4	Bcenmc03_0433	465275..466075 [-], 801	170731786	extracellular solute-binding protein
5	Bcenmc03_0434	466432..469623 [+], 3192	170731787	ImpA family type VI secretion-associated protein	TssI
6	Bcenmc03_0435	469675..474258 [+], 4584	170731788	YD repeat-containing protein
7	Bcenmc03_0436	474269..474478 [+], 210	170731789	hypothetical protein
8	Bcenmc03_0437	474702..476498 [+], 1797	170731790	YD repeat-containing protein
9	Bcenmc03_0438	477482..477916 [+], 435	170731791	hypothetical protein
10	Bcenmc03_0439	477992..478438 [+], 447	170731792	YD repeat-containing protein
11	Bcenmc03_0440	478662..478979 [+], 318	170731793	hypothetical protein
12	Bcenmc03_0441	479068..479850 [-], 783	170731794	hypothetical protein	TssL
13	Bcenmc03_0442	479847..481193 [-], 1347	170731795	type VI secretion protein	TssK
14	Bcenmc03_0443	481296..481907 [-], 612	170731796	hypothetical protein	TssJ
15	Bcenmc03_0444	482280..482915 [+], 636	170731797	hypothetical protein
16	Bcenmc03_0445	482962..483477 [+], 516	170731798	type VI secretion protein	TssB
17	Bcenmc03_0446	483493..484983 [+], 1491	170731799	EvpB family type VI secretion protein	TssC
18	Bcenmc03_0447	485054..485557 [+], 504	170731800	Hcp1 family type VI secretion system effector	TssD
19	Bcenmc03_0448	485620..486105 [+], 486	170731801	type VI secretion system lysozyme-like protein	TssE
20	Bcenmc03_0449	486182..488017 [+], 1836	170731802	type VI secretion protein	TssF
21	Bcenmc03_0450	487981..489081 [+], 1101	170731803	type VI secretion protein	TssG
22	Bcenmc03_0451	489123..491792 [+], 2670	170731804	type VI secretion ATPase	TssH
23	Bcenmc03_0452	491837..492958 [+], 1122	170731805	ImpA family type VI secretion-associated protein	TssA
24	Bcenmc03_0453	493275..494105 [+], 831	170731806	hypothetical protein
25	Bcenmc03_0454	494174..494347 [+], 174	170731807	hypothetical protein
26	Bcenmc03_0455	494340..495260 [+], 921	170731808	hypothetical protein
27	Bcenmc03_0456	495247..495429 [+], 183	170731809	hypothetical protein
28	Bcenmc03_0457	495548..496498 [-], 951	170731810	OmpA/MotB domain-containing protein	TagL
29	Bcenmc03_0458	496503..497492 [-], 990	170731811	hypothetical protein
30	Bcenmc03_0459	497489..501433 [-], 3945	170731812	type VI secretion protein IcmF	TssM
31	Bcenmc03_0460	501735..502580 [-], 846	170731813	peptidase M15B and M15C DD-carboxypeptidase VanY/endolysin
32	Bcenmc03_0461	502702..503694 [+], 993	170731814	hypothetical protein
33	Bcenmc03_0462	503906..504934 [+], 1029	170731815	Mg2 transporter protein CorA family protein
34	Bcenmc03_0463	504962..505114 [-], 153	170731816	hypothetical protein
35	Bcenmc03_0464	505139..506116 [-], 978	170731817	alcohol dehydrogenase

 Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.

1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

Homology Effector list

BCAL0343 , BTH_I2697, BTH_I2705

Effector identified
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Homolog
1	Bcenmc03_0447	485054..485557 [+], 504	170731800	Hcp1 family type VI secretion system effector	BCAL0343
2	Bcenmc03_2209	2471828..2474515 [-], 2688	170733545	ImpA family type VI secretion-associated protein	BTH_I2697
3	Bcenmc03_2212	2476634..2479579 [-], 2946	170733548	ImpA family type VI secretion-associated protein	BTH_I2705

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Proteins        Genes

N/A

N/A