SecReT6
I. Summary
SecReT6 ID272 experimental
StrainProteus mirabilis HI4320
Repliconchromosome [Browse all T6SS(s) in this replicon]
AccessionNC_010554
Location807789..834462
CommentA preemptive mechanism by which an entire population indiscriminately uses the T6SS for contact-dependent delivery of effectors during its cooperative mode of growth
Functionanti-bacterial
T6SS TypeType i; subtype i1
experimental Experimental investigation has been performed on this T6SS.

II. T6SS components
ComponentTssHTssDTssLTssITssATssBTssCTssETssF
Number121121112
ComponentTssGTssJTssKTssM
Number1111
III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1PMI_RS03585 (aphA)803332..804045 [+], 714490367974acid phosphatase AphA 
2PMI_RS03590 (ldtD)804395..806110 [+], 1716501336081L,D-transpeptidase 
3PMI_RS03595806448..806996 [+], 549490364940YcbK family protein 
4PMI_RS03600807046..807696 [+], 651501336082MBL fold metallo-hydrolase 
5PMI_RS03605807789..808262 [-], 474490364942Hcp family type VI secretion system effector 
6PMI_RS03610808353..810089 [-], 1737501336083type VI secretion system baseplate subunit TssF 
7PMI_RS03615810082..811437 [-], 1356501336084type VI secretion system ImpA family N-terminal domain-containing protein 
8PMI_RS03620 (tssM)811475..815023 [-], 3549490364945type VI secretion system membrane subunit TssM 
9PMI_RS03625 (tssA)815026..816489 [-], 1464501336085type VI secretion system protein TssA 
10PMI_RS03630 (tagO)816495..817145 [-], 651490364947type VI secretion system-associated protein TagO 
11PMI_RS03635817147..817935 [-], 789490364949hypothetical protein 
12PMI_RS03640 (tssH)817939..820650 [-], 2712501336086type VI secretion system ATPase TssH 
13PMI_RS03645 (icmH)820659..821414 [-], 756490364952type IVB secretion system protein IcmH/DotU 
14PMI_RS03650 (tssK)821407..822765 [-], 1359490367984type VI secretion system baseplate subunit TssK 
15PMI_RS03655 (tssJ)822767..823318 [-], 552490364954type VI secretion system lipoprotein TssJ 
16PMI_RS03660 (tagH)823320..824588 [-], 1269501336087type VI secretion system-associated FHA domain protein TagH 
17PMI_RS03665 (tssG)824593..825630 [-], 1038490364956type VI secretion system baseplate subunit TssG 
18PMI_RS03670 (tssF)825594..827369 [-], 1776501336088type VI secretion system baseplate subunit TssF 
19PMI_RS03675 (tssE)827377..827808 [-], 432490364959type VI secretion system baseplate subunit TssE 
20PMI_RS03680 (tssC)827814..829292 [-], 1479490367989type VI secretion system contractile sheath large subunit 
21PMI_RS03685 (tssB)829313..829813 [-], 501490367990type VI secretion system contractile sheath small subunit 
22PMI_RS03690831710..832228 [+], 519501336089Hcp family type VI secretion system effector 
23PMI_RS03695 (tssI)832312..834360 [+], 2049pseudogenetype VI secretion system tip protein VgrG 
24PMI_RS03700834465..834995 [+], 531490364965hypothetical protein 
25PMI_RS03705835010..836065 [+], 1056490364966DUF2169 domain-containing protein 
26PMI_RS03710836068..837093 [+], 10265013360913-oxoacyl-ACP synthase 
27PMI_RS03715837094..838668 [+], 1575501336092DUF4150 domain-containing protein 
 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.
 






2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.
 






3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.
 







Homology Effector list
ECA2866 , ECA2866, idrB, ECA2866, idrB, ECA2866, idsB, idsD

Effector identified
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog

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Proteins        Genes
N/A
The information on regulator interaction.

#homolog effector locus tagRegulator wayFunctionRegulate targetDescription
1MrpJTranscription regulatorPMI0749 (tssA)MrpJ directly binds and regulates parts of T6SS genes promotor.
2MrpJPMI2990 (idsA/hcp).
(1) Alteri CJ et al. (2013). Multicellular Bacteria Deploy the Type VI Secretion System to Preemptively Strike Neighboring Cells. PLoS Pathog. 9(9):e1003608. [PudMed:24039579] experimental in_silico
(2) Wenren LM et al. (2013). Two Independent Pathways for Self-Recognition in Proteus mirabilis Are Linked by Type VI-Dependent Export. MBio. 4(4). [PudMed:23882014] experimental
 
experimental This literature contains experimental investigation
in_silico This literature contains bioinformatics investigation