I. Summary
SecReT6 ID272 experimental
StrainProteus mirabilis HI4320
Repliconchromosome [Browse all T6SS(s) in this replicon]
CommentA preemptive mechanism by which an entire population indiscriminately uses the T6SS for contact-dependent delivery of effectors during its cooperative mode of growth
T6SS TypeType i; subtype i1
experimental Experimental investigation has been performed on this T6SS.

II. T6SS components
III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1PMI0729 (aphA)803332..804045 [+], 714197284623acid phosphatase/phosphotransferase 
2PMI0730804395..806110 [+], 1716197284624hypothetical protein 
3PMI0731806448..806996 [+], 549197284625hypothetical protein 
4PMI0732807046..807696 [+], 651197284626metallo-beta-lactamase superfamily protein 
5PMI0733807789..808262 [-], 474197284627hypothetical protein  TssD
6PMI0734808353..810089 [-], 1737197284628hypothetical protein  TssF
7PMI0735810082..811437 [-], 1356197284629hypothetical protein  TssA
8PMI0736811475..815023 [-], 3549197284630hypothetical protein  TssM
9PMI0737815026..816489 [-], 1464197284631hypothetical protein  TssA
10PMI0738816495..817145 [-], 651197284632hypothetical protein 
11PMI0739817147..817935 [-], 789197284633hypothetical protein 
12PMI0740817939..820650 [-], 2712197284634ATPase  TssH
13PMI0741820659..821414 [-], 756197284635hypothetical protein  TssL
14PMI0742821407..822765 [-], 1359197284636hypothetical protein  TssK
15PMI0743822767..823318 [-], 552197284637lipoprotein  TssJ
16PMI0744823320..824588 [-], 1269197284638phosphopeptide-binding protein  Fha
17PMI0745824593..825630 [-], 1038197284639hypothetical protein  TssG
18PMI0746825594..827369 [-], 1776197284640hypothetical protein  TssF
19PMI0747827377..827808 [-], 432197284641hypothetical protein  TssE
20PMI0748827814..829313 [-], 1500197284642hypothetical protein  TssC
21PMI0749829313..829813 [-], 501197284643hypothetical protein  TssB
22PMI0750831710..832228 [+], 519197284644hypothetical protein  TssD
23PMI0751832312..834462 [+], 2151197284645VgrG-like protein  TssI
24PMI0752834465..834995 [+], 531197284646hypothetical protein 
25PMI0753835010..836065 [+], 1056197284647hypothetical protein 
26PMI0754836068..837093 [+], 1026197284648hypothetical protein 
27PMI0755837094..838668 [+], 1575197284649hypothetical protein 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

Homology Effector list
ECA2866 , ECA2866, idrB, ECA2866, idrB, ECA2866, idsB, idsD

Effector identified
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1PMI0207(hcp)245183..245701 [+], 519197284116hypothetical protein ECA2866
2PMI0750831710..832228 [+], 519197284644hypothetical protein ECA2866
3PMI0751832312..834462 [+], 2151197284645VgrG-like protein idrB
4PMI1117(hcp)1185979..1186497 [+], 519197284988hypothetical protein ECA2866
5PMI11181186581..1188683 [+], 2103197284989Rhs family protein idrB
6PMI29903278930..3279448 [+], 519197286819hypothetical protein ECA2866
7PMI29913279686..3281692 [+], 2007197286820VgrG-like protein idsB
8PMI29933282912..3286013 [+], 3102197286822hypothetical protein idsD

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Proteins        Genes
The information on regulator interaction.

#homolog effector locus tagRegulator wayFunctionRegulate targetDescription
1MrpJTranscription regulatorPMI0749 (tssA)MrpJ directly binds and regulates parts of T6SS genes promotor.
2MrpJPMI2990 (idsA/hcp).
(1) Alteri CJ et al. (2013). Multicellular Bacteria Deploy the Type VI Secretion System to Preemptively Strike Neighboring Cells. PLoS Pathog. 9(9):e1003608. [PudMed:24039579] experimental in_silico
(2) Wenren LM et al. (2013). Two Independent Pathways for Self-Recognition in Proteus mirabilis Are Linked by Type VI-Dependent Export. MBio. 4(4). [PudMed:23882014] experimental
experimental This literature contains experimental investigation
in_silico This literature contains bioinformatics investigation