I. Summary
SecReT6 ID294 insolico
StrainSalmonella enterica subsp. enterica serovar Heidelberg str. SL476
Repliconchromosome [Browse all T6SS(s) in this replicon]
T6SS TypeType i; subtype i3
insolico Bioinformatics investigation has been performed on this T6SS.

II. T6SS components
III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1SeHA_C0298 (mltD)307690..308910 [-], 1221194447758membrane-bound lytic murein transglycosylase D 
2SeHA_C0299 (gloB)309129..309884 [-], 756194448453hydroxyacylglutathione hydrolase 
3SeHA_C0300309919..310641 [+], 723194447422putative methyltransferase 
4SeHA_C0301 (rnhA)310638..311105 [-], 468194447817ribonuclease H 
5SeHA_C0302 (dnaQ)311160..311900 [+], 741194449519DNA polymerase III subunit epsilon 
6SeHA_C0304312432..313481 [-], 1050194448891ImpA-related N- family protein  TssA
7SeHA_C0305313498..314493 [-], 996194449954type VI secretion protein, family  TssG
8SeHA_C0306 (vasA)314490..316373 [-], 1884194450586type VI secretion protein, family  TssF
9SeHA_C0307316389..316883 [-], 495194448005type VI secretion system lysozyme-related protein  TssE
10SeHA_C0308316880..317704 [-], 825194448663hypothetical protein  TagJ
11SeHA_C0309317691..318581 [-], 891194451902hypothetical protein 
12SeHA_C0310 (clpV)318961..321600 [+], 2640194447312type VI secretion ATPase, ClpV1 family  TssH
13SeHA_C0311321700..322242 [+], 543194450746type VI secretion protein, family  TssB
14SeHA_C0312322266..323774 [+], 1509194451223type VI secretion protein, EvpB/family  TssC
15SeHA_C0313324200..324625 [+], 426194449319hypothetical protein  STY0301 (i)
16SeHA_C0314324862..325347 [+], 486194449410hemolysin-coregulated protein  TssD
17SeHA_C0315325650..326135 [+], 486194451673hypothetical protein  STM0277 (e)
18SeHA_C0316326171..326503 [+], 333194450862hypothetical protein  STM0278 (i)
19SeHA_C0317326646..327131 [+], 486194450289hemolysin-coregulated protein  TssD
20SeHA_C0318327244..327735 [+], 492194450687type VI secretion lipoprotein, family  TssJ
21SeHA_C0319327739..329082 [+], 1344194449621type VI secretion protein, family  TssK
22SeHA_C0320329079..330383 [+], 1305194448829hypothetical protein  TssL
23SeHA_C0321330388..331161 [+], 774194448115hypothetical protein 
24SeHA_C0322331439..331795 [+], 357194447467hypothetical protein 
25SeHA_C0323 (icmF)331829..335698 [+], 3870194449827type VI secretion protein IcmF  TssM
26SeHA_C0324335698..336465 [+], 768194451777hypothetical protein 
27SeHA_C0325337068..337424 [+], 357194451567hypothetical protein 
28SeHA_C0326337433..337555 [+], 123194450921hypothetical protein 
29SeHA_C0327337582..337968 [+], 387194448427hypothetical protein 
30SeHA_C0328337995..338513 [+], 519194447757hypothetical protein 
31SeHA_C0329338910..341141 [+], 2232194450123Rhs family protein  TssI
32SeHA_C0330341201..341659 [+], 459194449492hypothetical protein 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

Homology Effector list
SciK , Hcp, SciK, STY2606, STM0277

Effector identified
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1SeHA_C0314324862..325347 [+], 486194449410hemolysin-coregulated protein SciK
2SeHA_C33753283339..3283824 [-], 486194449910hypothetical protein Hcp
3SeHA_C0317326646..327131 [+], 486194450289hemolysin-coregulated protein SciK
4SeHA_C26172531686..2532054 [+], 369194451450hypothetical protein STY2606
5SeHA_C0315325650..326135 [+], 486194451673hypothetical protein STM0277

Download FASTA format files
Proteins        Genes

Homology Immunity protein list
STY0301, STY2607, STM0278

Immunity protein identified
#Locus tag(Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1SeHA_C0313324200..324625 [+], 426194449319hypothetical protein STY0301
2SeHA_C26182532054..2532572 [+], 519194449876hypothetical protein STY2607
3SeHA_C0316326171..326503 [+], 333194450862hypothetical protein STM0278

Download FASTA format files
Proteins        Genes
(1) Blondel CJ et al. (2009). Comparative genomic analysis uncovers 3 novel loci encoding type six secretion systems differentially distributed in Salmonella serotypes. BMC Genomics. 10:354. [PudMed:19653904] in_silico
in_silico This literature contains bioinformatics investigation