I. Summary
SecReT6 ID301 experimental
StrainSalmonella enterica subsp. enterica serovar Dublin str. CT_02021853
Repliconchromosome [Browse all T6SS(s) in this replicon]
CommentInvolved in colonization of the avian and murine hosts
Functionanti-eukaryotic; virulence
T6SS TypeType i; subtype i3
experimental Experimental investigation has been performed on this T6SS.

II. T6SS components
III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1SeD_A0283 (mltD)300759..301979 [-], 1221198243785membrane-bound lytic murein transglycosylase D 
2SeD_A0284 (gloB)302198..302953 [-], 756198244534hydroxyacylglutathione hydrolase 
3SeD_A0285302988..303710 [+], 723198243385methyltransferase 
4SeD_A0286 (rnhA)303707..304174 [-], 468198242273ribonuclease H 
5SeD_A0287 (dnaQ)304229..304969 [+], 741198244203DNA polymerase III subunit epsilon 
6SeD_A0289305501..306556 [-], 1056198245787ImpA-related protein  TssA
7SeD_A0290306567..307502 [-], 936198245445SciB protein  TssG
8SeD_A0292309412..309906 [-], 495198241906hypothetical protein  TssE
9SeD_A0293309903..310727 [-], 825198242047SciE protein  TagJ
10SeD_A0294310714..311604 [-], 891198242192hypothetical protein 
11SeD_A0295311984..314623 [+], 2640198243880ATPase  TssH
12SeD_A0296314723..315265 [+], 543198244612hypothetical protein  TssB
13SeD_A0297315289..316797 [+], 1509198243093SciI protein  TssC
14SeD_A0298317071..317250 [+], 180198243970hypothetical protein 
15SeD_A0299317263..317709 [+], 447198244319hypothetical protein 
16SeD_A0300317961..318446 [+], 486198244078hemolysin-coregulated protein  TssD
17SeD_A0301318558..319049 [+], 492198244689SciN protein  TssJ
18SeD_A0302319053..320396 [+], 1344198245302hypothetical protein  TssK
19SeD_A0303320393..321697 [+], 1305198245916hypothetical protein  TssL
20SeD_A0304321702..322475 [+], 774198242259inner membrane protein 
21SeD_A0305322753..323109 [+], 357198242773SciR protein 
22SeD_A0306323143..327012 [+], 3870198242462SciS protein  TssM
23SeD_A0307327012..327800 [+], 789198243222hypothetical protein 
24SeD_A0308327827..328213 [+], 387198242568hypothetical protein 
25SeD_A0309328240..328758 [+], 519198244209hypothetical protein 
26SeD_A0310329155..331344 [+], 2190198243551Rhs family protein  TssI
27SeD_A0311331368..331814 [+], 447198242189hypothetical protein 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

Homology Effector list
SciK , STY2606

Effector identified
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1SeD_A0300317961..318446 [+], 486198244078hemolysin-coregulated protein SciK
2SeD_A27282608078..2608446 [+], 369198244734hypothetical protein STY2606

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Proteins        Genes

Homology Immunity protein list

Immunity protein identified
#Locus tag(Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1SeD_A27292608446..2608964 [+], 519198242944hypothetical protein STY2607

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Proteins        Genes
(1) Pezoa D et al. (2014). Only one of the two type VI secretion systems encoded in the Salmonella enterica serotype Dublin genome is involved in colonization of the avian and murine hosts. Vet Res. 45(1):2. [PudMed:24405577] experimental
(2) Blondel CJ et al. (2009). Comparative genomic analysis uncovers 3 novel loci encoding type six secretion systems differentially distributed in Salmonella serotypes. BMC Genomics. 10:354. [PudMed:19653904] in_silico
experimental This literature contains experimental investigation
in_silico This literature contains bioinformatics investigation