SecReT6
I. Summary
SecReT6 ID301 experimental
StrainSalmonella enterica subsp. enterica serovar Dublin str. CT_02021853
Repliconchromosome [Browse all T6SS(s) in this replicon]
AccessionNC_011205
Location305501..331344
CommentInvolved in colonization of the avian and murine hosts
Functionanti-eukaryotic; virulence
T6SS TypeType i; subtype i3
experimental Experimental investigation has been performed on this T6SS.

II. T6SS components
ComponentTssHTssDTssLTssITssATssBTssCTssETssF
Number111111110
ComponentTssGTssJTssKTssM
Number1111
III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1SED_RS01760 (mltD)300759..302126 [-], 1368446567360murein transglycosylase D 
2SED_RS01765 (gloB)302198..302953 [-], 756446975518hydroxyacylglutathione hydrolase 
3SED_RS01770302988..303710 [+], 723446723917class I SAM-dependent methyltransferase 
4SED_RS01775 (rnhA)303707..304174 [-], 468446840616ribonuclease HI 
5SED_RS01780 (dnaQ)304238..304969 [+], 732487401775DNA polymerase III subunit epsilon 
6SED_RS01790305501..306556 [-], 1056446289771ImpA family type VI secretion system protein 
7SED_RS01795 (tssG)306567..307562 [-], 996446067384type VI secretion system baseplate subunit TssG 
8SED_RS01800 (tssF)307474..309396 [-], 1923487407669type VI secretion system baseplate subunit TssF 
9SED_RS01805 (tssE)309412..309906 [-], 495446030152type VI secretion system baseplate subunit TssE 
10SED_RS01810309903..310727 [-], 825446673202hypothetical protein 
11SED_RS01815 (tagK)310714..311616 [-], 903446729371type VI secretion system-associated protein TagK 
12SED_RS01825 (tssH)311984..314623 [+], 2640446371929type VI secretion system ATPase TssH 
13SED_RS01830 (tssB)314723..315265 [+], 543446919561type VI secretion system contractile sheath small subunit 
14SED_RS01835 (tssC)315289..316797 [+], 1509445936026type VI secretion system contractile sheath large subunit 
15SED_RS26190316864..317250 [+], 387446245659BPSL0067 family protein 
16SED_RS01845317377..317709 [+], 333501524592hypothetical protein 
17SED_RS01850317961..318446 [+], 486446234937type VI secretion system tube protein Hcp 
18SED_RS01855 (tssJ)318513..319049 [+], 537446929847type VI secretion system lipoprotein TssJ 
19SED_RS01860 (tssK)319053..320396 [+], 1344446040877type VI secretion system baseplate subunit TssK 
20SED_RS01865 (tssL)320393..321697 [+], 1305446054631type VI secretion system protein TssL, long form 
21SED_RS01870321702..322475 [+], 774446899299hypothetical protein 
22SED_RS01875322678..323109 [+], 4321149979959Shiga toxin A subunit 
23SED_RS01880 (tssM)323143..327012 [+], 3870447091711type VI secretion system membrane subunit TssM 
24SED_RS01885327012..327800 [+], 789447176872DUF2094 domain-containing protein 
25SED_RS01890327797..328213 [+], 417446682296DUF2195 family protein 
26SED_RS01895328237..328758 [+], 522446891128DUF2778 domain-containing protein 
27SED_RS01900329155..331344 [+], 2190445933675type VI secretion system tip protein VgrG 
28SED_RS01905331368..331814 [+], 447446297979DcrB-related protein 
29SED_RS01910331833..335584 [+], 3752pseudogenePAAR domain-containing protein 
30SED_RS24315335568..335909 [+], 342487660856hypothetical protein 
 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.
 






2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.
 






3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.
 







Homology Effector list
SciK , STY2606

Effector identified
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog

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Proteins        Genes

Homology Immunity protein list
STY2607

Immunity protein identified
#Locus tag(Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog

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Proteins        Genes
(1) Pezoa D et al. (2014). Only one of the two type VI secretion systems encoded in the Salmonella enterica serotype Dublin genome is involved in colonization of the avian and murine hosts. Vet Res. 45(1):2. [PudMed:24405577] experimental
(2) Blondel CJ et al. (2009). Comparative genomic analysis uncovers 3 novel loci encoding type six secretion systems differentially distributed in Salmonella serotypes. BMC Genomics. 10:354. [PudMed:19653904] in_silico
 
experimental This literature contains experimental investigation
in_silico This literature contains bioinformatics investigation