I. Summary

SecReT6 ID	301
Strain	Salmonella enterica subsp. enterica serovar Dublin str. CT_02021853
Replicon	chromosome [Browse all T6SS(s) in this replicon]
Accession	NC_011205
Location	305501..331344
Comment	Involved in colonization of the avian and murine hosts
Function	anti-eukaryotic; virulence
T6SS Type	Type i; subtype i3
Experimental investigation has been performed on this T6SS.

II. T6SS components

Component	TssH	TssD	TssL	TssI	TssA	TssB	TssC	TssE	TssF
Number	1	1	1	1	1	1	1	1	0
Component	TssG	TssJ	TssK	TssM
Number	1	1	1	1

III. genome coordinates of the T6SS gene cluster
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Note
1	SED_RS01760 (mltD)	300759..302126 [-], 1368	446567360	murein transglycosylase D
2	SED_RS01765 (gloB)	302198..302953 [-], 756	446975518	hydroxyacylglutathione hydrolase
3	SED_RS01770	302988..303710 [+], 723	446723917	class I SAM-dependent methyltransferase
4	SED_RS01775 (rnhA)	303707..304174 [-], 468	446840616	ribonuclease HI
5	SED_RS01780 (dnaQ)	304238..304969 [+], 732	487401775	DNA polymerase III subunit epsilon
6	SED_RS01790	305501..306556 [-], 1056	446289771	ImpA family type VI secretion system protein
7	SED_RS01795 (tssG)	306567..307562 [-], 996	446067384	type VI secretion system baseplate subunit TssG
8	SED_RS01800 (tssF)	307474..309396 [-], 1923	487407669	type VI secretion system baseplate subunit TssF
9	SED_RS01805 (tssE)	309412..309906 [-], 495	446030152	type VI secretion system baseplate subunit TssE
10	SED_RS01810	309903..310727 [-], 825	446673202	hypothetical protein
11	SED_RS01815 (tagK)	310714..311616 [-], 903	446729371	type VI secretion system-associated protein TagK
12	SED_RS01825 (tssH)	311984..314623 [+], 2640	446371929	type VI secretion system ATPase TssH
13	SED_RS01830 (tssB)	314723..315265 [+], 543	446919561	type VI secretion system contractile sheath small subunit
14	SED_RS01835 (tssC)	315289..316797 [+], 1509	445936026	type VI secretion system contractile sheath large subunit
15	SED_RS26190	316864..317250 [+], 387	446245659	BPSL0067 family protein
16	SED_RS01845	317377..317709 [+], 333	501524592	hypothetical protein
17	SED_RS01850	317961..318446 [+], 486	446234937	type VI secretion system tube protein Hcp
18	SED_RS01855 (tssJ)	318513..319049 [+], 537	446929847	type VI secretion system lipoprotein TssJ
19	SED_RS01860 (tssK)	319053..320396 [+], 1344	446040877	type VI secretion system baseplate subunit TssK
20	SED_RS01865 (tssL)	320393..321697 [+], 1305	446054631	type VI secretion system protein TssL, long form
21	SED_RS01870	321702..322475 [+], 774	446899299	hypothetical protein
22	SED_RS01875	322678..323109 [+], 432	1149979959	Shiga toxin A subunit
23	SED_RS01880 (tssM)	323143..327012 [+], 3870	447091711	type VI secretion system membrane subunit TssM
24	SED_RS01885	327012..327800 [+], 789	447176872	DUF2094 domain-containing protein
25	SED_RS01890	327797..328213 [+], 417	446682296	DUF2195 family protein
26	SED_RS01895	328237..328758 [+], 522	446891128	DUF2778 domain-containing protein
27	SED_RS01900	329155..331344 [+], 2190	445933675	type VI secretion system tip protein VgrG
28	SED_RS01905	331368..331814 [+], 447	446297979	DcrB-related protein
29	SED_RS01910	331833..335584 [+], 3752	pseudogene	PAAR domain-containing protein
30	SED_RS24315	335568..335909 [+], 342	487660856	hypothetical protein

 Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.

1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

Homology Effector list

SciK , STY2606

Effector identified
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Homolog

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Proteins        Genes

Homology Immunity protein list

STY2607

Immunity protein identified
#	Locus tag(Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Homolog

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Proteins        Genes

(1) Pezoa D et al. (2014). Only one of the two type VI secretion systems encoded in the Salmonella enterica serotype Dublin genome is involved in colonization of the avian and murine hosts. Vet Res. 45(1):2. [PudMed:24405577]

(2) Blondel CJ et al. (2009). Comparative genomic analysis uncovers 3 novel loci encoding type six secretion systems differentially distributed in Salmonella serotypes. BMC Genomics. 10:354. [PudMed:19653904]

This literature contains experimental investigation

This literature contains bioinformatics investigation