SecReT6
I. Summary
SecReT6 ID303 experimental
StrainSalmonella enterica subsp. enterica serovar Gallinarum str. 287/91
Repliconchromosome [Browse all T6SS(s) in this replicon]
AccessionNC_011274
Location1114451..1137704
CommentColonisation of chicken ileum, caeca, liver and spleen
Functionanti-eukaryotic
T6SS TypeType i; subtype i1
experimental Experimental investigation has been performed on this T6SS.

II. T6SS components
ComponentTssHTssDTssLTssITssATssBTssCTssETssF
Number121121101
ComponentTssGTssJTssKTssM
Number1111
III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1SG_RS051801109709..1110815 [+], 1107pseudogeneGfo/Idh/MocA family oxidoreductase 
2SG_RS051851110982..1111275 [-], 294446036546hypothetical protein 
3SG_RS051901111306..1111524 [+], 219446803361hypothetical protein 
4SG_RS052001112125..1112583 [-], 459446546026DUF1311 domain-containing protein 
5SG_RS052051112707..1113078 [-], 372447150137hypothetical protein 
6SG_RS228301113087..1113530 [-], 4441102634496hypothetical protein 
7SG_RS052101113546..1114418 [-], 873446170355LysM peptidoglycan-binding domain-containing protein 
8SG_RS052151114451..1114930 [-], 480447207708Hcp family type VI secretion system effector 
9SG_RS052201114918..1116321 [-], 1404445998214type VI secretion system ImpA family N-terminal domain-containing protein 
10SG_RS05225 (tssM)1116332..1119793 [-], 3462447059852type VI secretion system membrane subunit TssM 
11SG_RS05230 (tssA)1119872..1121284 [-], 1413pseudogenetype VI secretion system protein TssA 
12SG_RS05235 (tagO)1121286..1122023 [-], 738446011293type VI secretion system-associated protein TagO 
13SG_RS052401122020..1124683 [-], 2664446536954AAA family ATPase 
14SG_RS052451124696..1125454 [-], 759446266123type IVB secretion system protein IcmH/DotU 
15SG_RS05250 (tssK)1125459..1126790 [-], 1332446168599type VI secretion system baseplate subunit TssK 
16SG_RS05255 (tssJ)1126793..1127296 [-], 5041524033542type VI secretion system lipoprotein TssJ 
17SG_RS05260 (tagH)1127323..1128609 [-], 1287446719629type VI secretion system-associated FHA domain protein TagH 
18SG_RS05265 (tssG)1128634..1129722 [-], 1089446431194type VI secretion system baseplate subunit TssG 
19SG_RS05270 (tssF)1129686..1131539 [-], 1854446316014type VI secretion system baseplate subunit TssF 
20SG_RS05275 (tssE)1131544..1131960 [-], 417446534352type VI secretion system baseplate subunit TssE 
21SG_RS05280 (tssC)1131957..1133429 [-], 1473445980146type VI secretion system contractile sheath large subunit 
22SG_RS05290 (tssB)1133720..1134223 [-], 504445953397type VI secretion system contractile sheath small subunit 
23SG_RS053001134853..1135371 [+], 519447065710Hcp family type VI secretion system effector 
24SG_RS053051135593..1137704 [+], 2112446025594type VI secretion system tip protein VgrG 
25SG_RS053101137806..1141606 [+], 3801pseudogeneRHS repeat protein 
26SG_RS240501141623..1142204 [+], 582487407310hypothetical protein 
27SG_RS053201142197..1142601 [+], 405446545186hypothetical protein 
 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.
 






2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.
 






3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.
 







Homology Effector list
ECA4275 , STY2606, Hcp

Effector identified
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog

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Proteins        Genes

Homology Immunity protein list
STY2607

Immunity protein identified
#Locus tag(Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog

Download FASTA format files
Proteins        Genes
(1) Pezoa D et al. (2013). The Type VI Secretion System Encoded in SPI-6 Plays a Role in Gastrointestinal Colonization and Systemic Spread of Salmonella enterica serovar Typhimurium in the Chicken. PLoS One. 8(5):e63917. [PudMed:23691117] experimental
(2) Blondel CJ et al. (2013). The Type VI Secretion System encoded in SPI-19 is required for Salmonella Gallinarum survival within infected macrophages. Infect Immun. 81(4):1207-20. [PudMed:23357385] experimental
(3) Silva CA et al. (2012). Infection of mice by Salmonella enterica serovar Enteritidis involves additional genes that are absent in the genome of serovar Typhimurium. Infect Immun. 80(2):839-49. [PudMed:22083712] experimental
(4) Blondel CJ et al. (2010). Contribution of the type VI secretion system encoded in SPI-19 to chicken colonization by Salmonella enterica serotypes Gallinarum and Enteritidis. PLoS One. 5(7):e11724. [PudMed:20661437] experimental
(5) Blondel CJ et al. (2009). Comparative genomic analysis uncovers 3 novel loci encoding type six secretion systems differentially distributed in Salmonella serotypes. BMC Genomics. 10:354. [PudMed:19653904] in_silico
 
experimental This literature contains experimental investigation
in_silico This literature contains bioinformatics investigation