I. Summary
SecReT6 ID344 insolico
StrainKlebsiella pneumoniae NTUH-K2044
Repliconchromosome [Browse all T6SS(s) in this replicon]
T6SS TypeType i; subtype i2
insolico Bioinformatics investigation has been performed on this T6SS.

II. T6SS components
III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1KP1_23872293921..2294835 [-], 915238894404LysR family transcriptional regulator 
2KP1_23882294914..2295705 [+], 7922388944057-alpha-hydroxysteroid dehydrogenase 
3KP1_23892295922..2297454 [+], 1533238894406putative metal-dependent phosphohydrolase with HD subdomain 
4KP1_23902297653..2298219 [-], 567238894407putative intracellular protease/amidase 
5KP1_23922298791..2299351 [+], 561238894408hypothetical protein  TssB
6KP1_23932299388..2300938 [+], 1551238894409hypothetical protein  TssC
7KP1_23952300951..2302291 [+], 1341238894410hypothetical protein  TssK
8KP1_23962302288..2302977 [+], 690238894411hypothetical protein  TssL
9KP1_23972302974..2304680 [+], 1707238894412putative outer membrane protein  TagL
10KP1_23982304685..2305176 [+], 492238894413hypothetical protein  TssD
11KP1_23992305440..2308094 [+], 2655238894414putative protease  TssH
12KP1_24002308066..2310786 [+], 2721238894415hypothetical protein  TssI
13KP1_24012310783..2311199 [+], 417238894416hypothetical protein 
14KP1_24022311217..2313139 [+], 1923238894417hypothetical protein 
15KP1_24032313136..2313567 [+], 432238894418hypothetical protein 
16KP1_24042313827..2313931 [+], 105238894419transposase 
17KP1_2405 (trp1400A)2313903..2314094 [+], 192238894420IS1400 transposase 
18KP1_24062314169..2314939 [+], 771238894421integrase catalytic subunit 
19KP1_24072314926..2315996 [+], 1071238894422hypothetical protein 
20KP1_24082315993..2316241 [+], 249238894423hypothetical protein 
21KP1_24092316183..2316518 [+], 336238894424maltose transport system permease component 
22KP1_24112316702..2316839 [+], 138238894425hypothetical protein 
23KP1_24122317254..2318474 [+], 1221238894426putative structural protein 
24KP1_24132318423..2321926 [+], 3504238894427hypothetical protein  TssM
25KP1_24142321926..2323524 [+], 1599238894428hypothetical protein  TssA
26KP1_24152323555..2324610 [+], 1056238894429hypothetical protein  PAAR
27KP1_24182324607..2325077 [+], 471238894430hypothetical protein 
28KP1_24192325154..2326908 [+], 1755238894431hypothetical protein  TssF
29KP1_24202326872..2327957 [+], 1086238894432hypothetical protein  TssG
30KP1_24212327935..2328477 [+], 543238894433hypothetical protein  TssJ
31KP1_24222328604..2329098 [+], 495238894434hypothetical protein 
32KP1_24232329165..2329878 [-], 714238894435oxidoreductase 
33KP1_24242329916..2330545 [+], 630238894436TetR family transcriptional regulator 
34KP1_24252330550..2331353 [-], 804238894437putative dehydrogenase/reductase oxidoreductase protein 
35KP1_2426 (yqhC)2331464..2332342 [+], 879238894438AraC family transcriptional regulator 
36KP1_24272332393..2332605 [-], 213238894439hypothetical protein 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

Homology Effector list

Effector identified
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1KP1_23982304685..2305176 [+], 492238894413hypothetical protein EC042_4529

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Proteins        Genes
The information on regulator interaction.

#homolog effector locus tagRegulator wayFunctionRegulate targetDescription
1KP1_3314 (hns)KP1_2392 (hcp)H-NS specifically binds to hcp region in K.pneumoniae NTUH-K2044 T6SS locus l and represses hcp expression and secretion .
2KP1_3314 (hns)Transcription regulator-KP1_2392 (TssB) promotorH-NS specifically binds to TssD region in K.pneumoniae NTUH-K2044 T6SS locus l.
(1) Sarris PF et al. (2011). Distribution of the putative type VI secretion system core genes in Klebsiella spp. Infect Genet Evol. 11(1):157-66. [PudMed:20932940] in_silico
in_silico This literature contains bioinformatics investigation