I. Summary

SecReT6 ID	352
Strain	Aggregatibacter aphrophilus NJ8700
Replicon	chromosome [Browse all T6SS(s) in this replicon]
Accession	NC_012913
Location	1837937..1852530
Comment
Function	N/A
T6SS Type	Type i; subtype i1
Bioinformatics investigation has been performed on this T6SS.

II. T6SS components

Component	TssH	TssD	TssL	TssI	TssA	TssB	TssC	TssE	TssF
Number	0	0	1	0	0	1	1	1	1
Component	TssG	TssJ	TssK	TssM
Number	1	1	1	1

III. genome coordinates of the T6SS gene cluster
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Note
1	NT05HA_1848	1833338..1834063 [-], 726	251793533	PnuC transporter
2	NT05HA_1849	1834225..1837083 [+], 2859	251793534	RNA polymerase-associated protein RapA
3	NT05HA_1850	1837086..1837745 [+], 660	251793535	ribosomal large subunit pseudouridine synthase A
4	NT05HA_1851	1837937..1838434 [+], 498	251793536	type VI secretion protein	TssB
5	NT05HA_1852	1838456..1839940 [+], 1485	251793537	type VI secretion protein, EvpB/family	TssC
6	NT05HA_1853	1839950..1840366 [+], 417	251793538	type VI secretion system lysozyme-like protein	TssE
7	NT05HA_1854	1840367..1842118 [+], 1752	251793539	type VI secretion protein	TssF
8	NT05HA_1855	1842082..1843080 [+], 999	251793540	type VI secretion protein	TssG
9	NT05HA_1856	1843082..1843867 [+], 786	251793541	hypothetical protein	Fha
10	NT05HA_1857	1843882..1844568 [+], 687	251793542	type VI secretion lipoprotein, family	TssJ
11	NT05HA_1858	1844572..1845915 [+], 1344	251793543	type VI secretion protein	TssK
12	NT05HA_1859	1845912..1846769 [+], 858	251793544	VasF	TssL
13	NT05HA_1860	1846795..1847421 [+], 627	251793545	hypothetical protein
14	NT05HA_1861	1847423..1848850 [+], 1428	251793546	hypothetical protein
15	NT05HA_1862	1849033..1852530 [+], 3498	251793547	type VI secretion protein IcmF	TssM
16	NT05HA_1863	1852725..1852856 [-], 132	251793548	hypothetical protein
17	NT05HA_1864	1853020..1856250 [+], 3231	251793549	outer membrane autotransporter barrel
18	NT05HA_1865 (ribB)	1856357..1857001 [-], 645	251793550	3,4-dihydroxy-2-butanone 4-phosphate synthase

 Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.

1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

Homology Effector list

ECA2866

Effector identified
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Homolog
1	NT05HA_1820	1811033..1811548 [+], 516	251793505	hemolysin co-regulated protein	ECA2866

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Proteins        Genes

N/A

(1) Di Bonaventura MP et al. (2009). Complete genome sequence of Aggregatibacter (Haemophilus) aphrophilus NJ8700. J Bacteriol. 191(14):4693-4. [PudMed:19447908]

This literature contains bioinformatics investigation