I. Summary

SecReT6 ID	443
Strain	Methylomonas methanica MC09
Replicon	chromosome [Browse all T6SS(s) in this replicon]
Accession	NC_015572
Location	915765..926524
Comment
Function	effector translocation
T6SS Type	Type i; subtype i3
Experimental investigation has been performed on this T6SS.

II. T6SS components

Component	TssH	TssD	TssL	TssI	TssA	TssB	TssC	TssE	TssF
Number	1	1	0	0	1	1	1	1	1
Component	TssG	TssJ	TssK	TssM
Number	1	0	0	0

III. genome coordinates of the T6SS gene cluster
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Note
1	Metme_0845	911243..912682 [+], 1440	333982573	ATP synthase subunit alpha
2	Metme_0846	912679..913491 [+], 813	333982574	ATP synthase F1 subunit gamma
3	Metme_0847	913546..914097 [-], 552	333982575	hypothetical protein
4	Metme_0848	914136..914303 [+], 168	333982576	hypothetical protein
5	Metme_0849	914912..915655 [+], 744	333982577	response regulator receiver and Hpt phospho transfer protein
6	Metme_0850	915765..916805 [+], 1041	333982578	type VI secretion-associated protein, ImpA family	TssA
7	Metme_0851	916832..917368 [+], 537	333982579	type VI secretion protein	TssB
8	Metme_0852	917372..918862 [+], 1491	333982580	type VI secretion protein	TssC
9	Metme_0853	918983..919465 [+], 483	333982581	type VI secretion system effector	TssD
10	Metme_0854	919535..920344 [+], 810	333982582	virulence protein SciE type	TagJ
11	Metme_0855	920347..920850 [+], 504	333982583	type VI secretion system lysozyme-like protein	TssE
12	Metme_0856	920853..922736 [+], 1884	333982584	type VI secretion protein	TssF
13	Metme_0857	922700..923764 [+], 1065	333982585	type VI secretion protein	TssG
14	Metme_0858	923804..926524 [+], 2721	333982586	type VI secretion ATPase, ClpV1 family	TssH
15	Metme_0859	926790..927809 [+], 1020	333982587	hypothetical protein
16	Metme_0860	927895..928224 [+], 330	333982588	hypothetical protein
17	Metme_0861	928491..929525 [+], 1035	333982589	hypothetical protein
18	Metme_0862	929576..929917 [+], 342	333982590	hypothetical protein
19	Metme_0863	929953..930384 [+], 432	333982591	hypothetical protein

 Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.

1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

Homology Effector list

PA2702

Effector identified
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Homolog
1	Metme_3457	3824035..3824514 [-], 480	333985114	hypothetical protein	PA2702
Data from experimental literature

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Proteins        Genes

Homology Immunity protein list

Metme_3456 (Tsi2_MM)

Immunity protein identified
#	Locus tag(Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Homolog

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Proteins        Genes

(1) Silverman JM et al. (2013). Haemolysin Coregulated Protein Is an Exported Receptor and Chaperone of Type VI Secretion Substrates. Mol Cell. 51(5):584-93. [PudMed:23954347]

This literature contains experimental investigation

This literature contains bioinformatics investigation