I. Summary
SecReT6 ID46 insolico
StrainShigella flexneri 2a str. 2457T
Repliconchromosome [Browse all T6SS(s) in this replicon]
insolico Bioinformatics investigation has been performed on this T6SS.

II. T6SS components
III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1S0200 (dkgB)219551..220354 [+], 804300617582,5-diketo-D-gluconate reductase B 
2S0201220393..221721 [-], 132930061759IS4 orf 
3S0202 (yafC)221789..222703 [-], 91530061760transcriptional regulator LYSR-type 
4S0203 (yafD)222944..223744 [+], 80130061761hypothetical protein 
5S0204 (yafE)223972..224592 [+], 62130061762biotin synthesis protein 
6S0205 (mltD)224640..225986 [-], 134730061763membrane-bound lytic murein transglycosylase D 
7S0206 (gloB)226058..226813 [-], 75630061764hydroxyacylglutathione hydrolase 
8S0207 (yafS)226844..227569 [+], 72630061765hypothetical protein 
9S0208 (rnhA)227566..228033 [-], 46830061766ribonuclease H 
10S0209 (dnaQ)228098..228829 [+], 73230061767DNA polymerase III subunit epsilon 
11S0211 (safA)229169..230215 [-], 104730061768hypothetical protein  TssA
12S0212230226..230339 [-], 11430061769hypothetical protein 
13S0213 (safB)230483..230788 [-], 30630061770periplasmic chaperone of fimbral assembly machinery  TssG
14S0214 (safC)230785..232668 [-], 188430061771outer membrane usher protein  TssF
15S0215232684..233178 [-], 49530061772hypothetical protein  TssE
16S0217 (sat1)233373..234005 [-], 63330061773hypothetical protein  TagJ
17S0218 (sat2)233992..234369 [-], 37830061774hypothetical protein 
18S0219234607..234906 [-], 30030061775hypothetical protein 
19S0220234959..235369 [+], 41130061776insertion sequence 2 OrfA protein 
20S0221235327..236232 [+], 90630061777insertion element IS2 transposase InsD 
21S0223236654..236956 [+], 30330061778IS911 orfA 
22S0224236983..237822 [+], 84030061779IS911 orfB 
23S0229238511..238780 [-], 27030061781endolysin R of prophage CP-933V 
24S0230239101..239415 [-], 31530061782hypothetical protein 
25S0231239420..239635 [-], 21630061783lysis protein S 
26S0232239992..240366 [+], 37530061784hypothetical protein 
27S0233240390..240797 [-], 40830061785hypothetical protein 
28S0235240794..241846 [-], 105330061786IS911 orfA 
29S0234240794..241633 [-], 84030061787IS911 orfB 
30S0236242170..242730 [+], 56130061788terminase large subunit 
31S0237242699..243073 [+], 37530061789terminase large subunit 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

(1) Boyer F et al. (2009). Dissecting the bacterial type VI secretion system by a genome wide in silico analysis: what can be learned from available microbial genomic resources. BMC Genomics. 10:104. [PudMed:19284603] in_silico
in_silico This literature contains bioinformatics investigation