I. Summary
SecReT6 ID463 experimental
StrainEscherichia coli 042
Repliconchromosome [Browse all T6SS(s) in this replicon]
Functioneffector translocation
T6SS TypeType i; subtype i2
experimental Experimental investigation has been performed on this T6SS.

II. T6SS components
III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1EC042_45164848505..4848717 [+], 213387609939putative plasmid-related regulatory protein 
2EC042_45184849334..4849903 [+], 570387609940hypothetical protein 
3EC042_45194850065..4850454 [+], 390387609941hypothetical protein 
4EC042_45214851172..4851795 [+], 624387609942hypothetical protein 
5EC042_45224851891..4852124 [+], 234387609943hypothetical protein 
6EC042_45234852177..4852368 [-], 192387609944hypothetical protein 
7EC042_45244852875..4853372 [+], 498387609945putative type VI secretion protein  TssB
8EC042_45254853394..4854938 [+], 1545387609946putative type VI secretion protein  TssC
9EC042_45264854954..4856291 [+], 1338387609947putative type VI secretion protein  TssK
10EC042_45274856288..4856941 [+], 654387609948putative type VI secretion protein  TssL
11EC042_45284856944..4858674 [+], 1731387609949putative type VI secretion protein  TagL
12EC042_45294858680..4859171 [+], 492387609950putative type VI secretion protein  TssD
13EC042_45304859340..4861997 [+], 2658387609951putative type VI secretion protein  TssH
14EC042_45314861994..4862560 [+], 567387609952putative type VI secretion protein 
15EC042_45324862554..4863096 [+], 543387609953putative type VI secretion protein 
16EC042_45334863083..4865608 [+], 2526387609954putative type VI secretion protein  TssI
17EC042_45344865605..4867287 [+], 1683387609955putative type VI secretion protein 
18EC042_45354867307..4867984 [+], 678387609956putative type VI secretion protein 
19EC042_45364868128..4868805 [+], 678387609957putative type VI secretion protein 
20EC042_45374868837..4869103 [+], 267387609958putative type VI secretion protein  PAAR
21EC042_45384869107..4870255 [+], 1149387609959putative type VI secretion protein 
22EC042_45394870248..4873637 [+], 3390387609960putative type VI secretion protein  TssM
23EC042_45404873637..4875235 [+], 1599387609961putative type VI secretion protein  TssA
24EC042_45414875237..4875929 [+], 693387609962putative type VI secretion protein 
25EC042_45424875937..4877700 [+], 1764387609963putative type VI secretion protein  TssF
26EC042_45434877754..4878755 [+], 1002387609964putative type VI secretion protein  TssG
27EC042_45444878736..4879272 [+], 537387609965putative type VI secretion protein  TssJ
28EC042_45454879275..4879706 [+], 432387609966putative type VI secretion protein  TssE
29EC042_45464879851..4880264 [+], 414387609967hypothetical protein 
30EC042_45474880420..4881664 [+], 1245387609968hypothetical protein 
31EC042_45484881858..4883645 [+], 1788387609969hypothetical protein 
32EC042_45494883710..4884015 [+], 306387609970hypothetical protein 
33EC042_45504884070..4885437 [+], 1368387609971hypothetical protein  TssA
34EC042_45514885652..4886212 [+], 561387609972hypothetical protein 
35EC042_45524886215..4887045 [+], 831387609973hypothetical protein 
36EC042_45534887086..4888318 [+], 1233387609974hypothetical protein 
37EC042_45544888303..4888947 [+], 645387609975ParB-like nuclease 
38EC042_45554889026..4889295 [+], 270387609976putative transcriptional regulator 
39EC042_45564889316..4889960 [+], 645387609977hypothetical protein 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

Homology Effector list

Effector identified
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1EC042_45294858680..4859171 [+], 492387609950putative type VI secretion protein EC042_4529
Data from experimental literature

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Proteins        Genes

Homology Immunity protein list

Immunity protein identified
#Locus tag(Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog

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Proteins        Genes
(1) Zoued A et al. (2013). TssK is a trimeric cytoplasmic protein interacting with components of both phage-like and membrane anchoring complexes of the Type VI secretion system. J Biol Chem. 288(38):27031-41. [PudMed:23921384] experimental
(2) Morin N et al. (2013). Characterization of the AggR regulon in enteroaggregative Escherichia coli. Infect Immun. 81(1):122-32. [PudMed:23090962] experimental
(3) Durand E et al. (2012). Structural characterization and oligomerization of the TssL protein, a component shared by bacterial type VI and type IVb secretion systems. J Biol Chem. 287(17):14157-68. [PudMed:22371492]
(4) Felisberto-Rodrigues C et al. (2011). Towards a structural comprehension of bacterial type VI secretion systems: characterization of the TssJ-TssM complex of an Escherichia coli pathovar. PLoS Pathog. 7(11):e1002386. [PudMed:22102820]
(5) Dudley EG et al. (2006). Proteomic and microarray characterization of the AggR regulon identifies a pheU pathogenicity island in enteroaggregative Escherichia coli. Mol Microbiol. 61(5):1267-82. [PudMed:16925558] experimental
experimental This literature contains experimental investigation