I. Summary
SecReT6 ID464 experimental
StrainEscherichia coli 042
Repliconchromosome [Browse all T6SS(s) in this replicon]
Functioneffector translocation
T6SS TypeType i; subtype i4b
experimental Experimental investigation has been performed on this T6SS.

II. T6SS components
III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1EC042_45544888303..4888947 [+], 645387609975ParB-like nuclease 
2EC042_45554889026..4889295 [+], 270387609976putative transcriptional regulator 
3EC042_45564889316..4889960 [+], 645387609977hypothetical protein 
4EC042_45624893076..4893552 [+], 477387609978putative type VI secretion protein  TssB
5EC042_45634893555..4895033 [+], 1479387609979putative type VI secretion protein  TssC
6EC042_45644895043..4895549 [+], 507387609980putative type VI secretion protein  AaiC (e)
7EC042_45654895559..4895981 [+], 423387609981putative type VI secretion protein  TssE
8EC042_45664895974..4897776 [+], 1803387609982putative type VI secretion protein  TssF
9EC042_45684897767..4898699 [+], 933387609983putative type VI secretion protein  TssG
10EC042_45694898712..4900694 [+], 1983387609984putative type VI secretion protein  TssI
11EC042_45704900705..4901172 [+], 468387609985putative type VI secretion protein 
12EC042_45714901182..4901481 [+], 300387609986putative type VI secretion protein  PAAR
13EC042_45724901485..4902561 [+], 1077387609987putative type VI secretion protein  TssA
14EC042_45734902569..4903120 [+], 552387609988putative type VI secretion protein  TssJ
15EC042_45744903139..4904551 [+], 1413387609989putative type VI secretion protein  TssK
16EC042_4574A4904579..4904893 [+], 315387609990putative type VI secretion protein 
17EC042_45754904890..4905480 [+], 591387609991putative type VI secretion protein  TssL
18EC042_45764905477..4908890 [+], 3414387609992putative type VI secretion protein  TssM
19EC042_45774908894..4911443 [+], 2550387609993putative type VI secretion protein  TssH
20EC042_4579B4913244..4913339 [+], 96387609994hypothetical protein 
21EC042_45804913767..4914027 [+], 261387609995hypothetical protein 
22EC042_45814914614..4915180 [+], 567387609996hypothetical protein 
23EC042_4581A4915245..4915525 [+], 281387609997transposase (partial) 
24EC042_4581B4915521..4915595 [+], 75387609998hypothetical protein 
25EC042_45824915659..4916813 [+], 1155387609999hypothetical protein 
26EC042_45834917198..4917605 [+], 408387610000hypothetical protein 
27EC042_45844918128..4919261 [+], 1134387610001transposase 
28EC042_45874920245..4921378 [+], 1134387610002putative transposase 
29EC042_45884921488..4923056 [-], 1569387610003transposase 
30EC042_45894923087..4923437 [-], 351387610004transposase 
31EC042_45904923434..4923868 [-], 435387610005transposase 
32EC042_45914923956..4924408 [+], 453387610006transposase 
33EC042_45924924447..4924689 [+], 243387610007transposase 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

Homology Effector list
EC042_4564 (AaiC)

Effector identified
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1EC042_45644895043..4895549 [+], 507387609980putative type VI secretion protein (AaiC)EC042_4564 (AaiC)
Data from experimental literature

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Proteins        Genes
Regulatory element identified
AggR (EC042_pAA052)Indirect activatorPMID: 16925558

(1) Morin N et al. (2013). Characterization of the AggR regulon in enteroaggregative Escherichia coli. Infect Immun. 81(1):122-32. [PudMed:23090962] experimental
(2) Dudley EG et al. (2006). Proteomic and microarray characterization of the AggR regulon identifies a pheU pathogenicity island in enteroaggregative Escherichia coli. Mol Microbiol. 61(5):1267-82. [PudMed:16925558] experimental
experimental This literature contains experimental investigation