SecReT6
I. Summary
SecReT6 ID464 experimental
StrainEscherichia coli 042
Repliconchromosome [Browse all T6SS(s) in this replicon]
AccessionNC_017626
Location4893076..4921378
Comment
Functioneffector translocation
T6SS TypeType i; subtype i4b
experimental Experimental investigation has been performed on this T6SS.

II. T6SS components
ComponentTssHTssDTssLTssITssATssBTssCTssETssF
Number101111111
ComponentTssGTssJTssKTssM
Number1111
III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1EC042_RS243204888303..4888947 [+], 645446425008ParB N-terminal domain-containing protein 
2EC042_RS243254889026..4889295 [+], 270446148662PerC family transcriptional regulator 
3EC042_RS243304889316..4889960 [+], 645485761812hypothetical protein 
4EC042_RS243354890026..4890349 [+], 324485761811hypothetical protein 
5EC042_RS243404890380..4890959 [-], 580pseudogenetransposase family protein 
6EC042_RS243504891169..4891555 [+], 387504779093hypothetical protein 
7EC042_RS288554891533..4891658 [+], 126485799638hypothetical protein 
8EC042_RS243554891664..4892680 [-], 1017pseudogeneIS630 family transposase 
9EC042_RS24360 (tssB)4893076..4893552 [+], 477445994694type VI secretion system contractile sheath small subunit 
10EC042_RS24365 (tssC)4893555..4895033 [+], 1479446137198type VI secretion system contractile sheath large subunit 
11EC042_RS24370 (aaiC)4895043..4895549 [+], 507446155335type VI secretion system protein AaiC/Hcp2 
12EC042_RS243754895559..4895981 [+], 423446477694hypothetical protein 
13EC042_RS24380 (tssF)4895974..4897776 [+], 1803485765577type VI secretion system baseplate subunit TssF 
14EC042_RS24385 (tssG)4897767..4898699 [+], 933447096717type VI secretion system baseplate subunit TssG 
15EC042_RS24390 (tssI)4898712..4900694 [+], 1983446120415type VI secretion system tip protein VgrG 
16EC042_RS243954900705..4901172 [+], 468445927225hypothetical protein 
17EC042_RS244004901182..4901481 [+], 300485765576PAAR domain-containing protein 
18EC042_RS24405 (tssA)4901485..4902561 [+], 1077446955899type VI secretion system protein TssA 
19EC042_RS244104902569..4903120 [+], 552446074890type VI secretion lipoprotein TssJ 
20EC042_RS24415 (tssK)4903139..4904551 [+], 1413447077409type VI secretion system baseplate subunit TssK 
21EC042_RS244254904890..4905480 [+], 591446950855DotU family type IV/VI secretion system protein 
22EC042_RS244304905486..4908890 [+], 3405485780182hypothetical protein 
23EC042_RS24435 (tssH)4908894..4911443 [+], 2550445951994type VI secretion system ATPase TssH 
24EC042_RS297354911640..4912851 [+], 1212pseudogeneIS3 family transposase 
25EC042_RS308554914614..4915180 [+], 567446510373hypothetical protein 
26EC042_RS304104915245..4915525 [+], 281pseudogenetransposase 
27EC042_RS244604915659..4916813 [+], 1155446282139type VI secretion system ImpA family N-terminal domain-containing protein 
28EC042_RS244704917879..4918067 [-], 189pseudogeneIS66 family transposase 
29EC042_RS244754918128..4919261 [+], 1134446477526IS110 family transposase 
30EC042_RS270454919301..4919663 [+], 3631148856341IS3 family transposase 
31EC042_RS288954919667..4919810 [+], 144pseudogeneIS3 family transposase 
32EC042_RS244854919996..4920184 [-], 189pseudogeneIS66 family transposase 
33EC042_RS244904920245..4921378 [+], 1134446477547IS110-like element ISEc45 family transposase 
34EC042_RS244954921632..4923056 [-], 1425pseudogeneIS66-like element ISEc43 family transposase 
35EC042_RS24500 (tnpB)4923087..4923437 [-], 351446547342IS66 family insertion sequence element accessory protein TnpB 
36EC042_RS245054923434..4923868 [-], 435485668600IS66 family insertion sequence hypothetical protein 
37EC042_RS245104923956..4924408 [+], 453pseudogenetransposase 
38EC042_RS245154924447..4924689 [+], 243pseudogeneIS256 family transposase 
 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.
 






2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.
 






3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.
 







Homology Effector list
EC042_4564 (AaiC)

Effector identified
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog

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Proteins        Genes
N/A
Regulatory element identified
AggR
RegulatorDescriptionReference
AggR (EC042_pAA052)Indirect activatorPMID: 16925558

(1) Morin N et al. (2013). Characterization of the AggR regulon in enteroaggregative Escherichia coli. Infect Immun. 81(1):122-32. [PudMed:23090962] experimental
(2) Dudley EG et al. (2006). Proteomic and microarray characterization of the AggR regulon identifies a pheU pathogenicity island in enteroaggregative Escherichia coli. Mol Microbiol. 61(5):1267-82. [PudMed:16925558] experimental
 
experimental This literature contains experimental investigation