I. Summary
SecReT6 ID47 experimental
StrainHelicobacter hepaticus ATCC 51449
Repliconchromosome [Browse all T6SS(s) in this replicon]
CommentAnti-inflammatory response in cultured intestinal epithelial cells and limitation of intestinal colonisation in mice (and perhaps therefore promotion of a tolerant, balanced relationship with host)
Functionanti-eukaryotic; effector translocation;virulence
T6SS TypeType i; subtype i1
experimental Experimental investigation has been performed on this T6SS.

II. T6SS components
III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1HH_RS09620223218..224333 [-], 1116752639969hypothetical protein 
2HH_RS01155224333..225118 [-], 786499427614hypothetical protein 
3HH_RS09625225105..226610 [-], 1506499427615hypothetical protein 
4HH_RS01165226607..227071 [-], 4651729640458hypothetical protein 
5HH_RS01170227242..228102 [-], 861pseudogeneVgrG protein 
6HH_RS01175228126..228986 [-], 861499427618Dam family site-specific DNA-(adenine-N6)-methyltransferase 
7HH_RS01180228983..229768 [-], 786499427619EcoRV family type II restriction endonuclease 
8HH_RS01185229864..230250 [-], 387499427620hypothetical protein 
9HH_RS01190230306..230749 [-], 4441729640488hypothetical protein 
10HH_RS01195231275..231583 [-], 309pseudogenehypothetical protein 
11HH_RS09280231618..234416 [-], 2799499427622hypothetical protein  TssI
12HH_RS01205234543..235052 [-], 510499427623Hcp family type VI secretion system effector  TssD
13HH_RS01210 (tssG)235149..236147 [-], 9991729640459type VI secretion system baseplate subunit TssG  TssG
14HH_RS01215 (tssF)236141..237856 [-], 1716499427625type VI secretion system baseplate subunit TssF  TssF
15HH_RS01220237926..238315 [-], 390499427626hypothetical protein 
16HH_RS01225 (tssC)238319..239791 [-], 1473499427627type VI secretion system contractile sheath large subunit  TssC
17HH_RS01230 (tssB)239839..240336 [-], 498499427628type VI secretion system contractile sheath small subunit  TssB
18HH_RS01235 (tssJ)240524..241060 [+], 537499427629type VI secretion system lipoprotein TssJ  TssJ
19HH_RS01240 (tssK)241053..242432 [+], 1380499427630type VI secretion system baseplate subunit TssK  TssK
20HH_RS01245242444..243232 [+], 789499427631type IVB secretion system protein IcmH/DotU  TssL
21HH_RS01250 (tssM)243237..246791 [+], 3555499427632type VI secretion system membrane subunit TssM  TssM
22HH_RS01255246801..247781 [+], 981499427633hypothetical protein  Fha
23HH_RS01260247872..249140 [-], 1269499427634hypothetical protein 
24HH_RS01265249168..253067 [-], 3900499427635hypothetical protein 
25HH_RS09395254247..254729 [-], 483pseudogenehypothetical protein 
26HH_RS09125254722..255006 [-], 285914777955hypothetical protein 
27HH_RS01285256069..256437 [-], 369499427638hypothetical protein 
28HH_RS09295256448..256822 [-], 3751180231518hypothetical protein 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

Download FASTA format files
Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

Homology Effector list
HH0242 , HH0243, HH0242

Effector identified
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog

Download FASTA format files
Proteins        Genes
(1) Bartonickova L et al. (2013). Hcp and VgrG1 are secreted components of the Helicobacter hepaticus type VI secretion system and VgrG1 increases the bacterial colitogenic potential. Cell Microbiol. 15(6):992-1011. [PudMed:23278999] experimental
(2) Chow J et al. (2010). A pathobiont of the microbiota balances host colonization and intestinal inflammation. Cell Host Microbe. 7(4):265-76. [PudMed:20413095] experimental
(3) Ge Z et al. (2008). Helicobacter hepaticus HHGI1 is a pathogenicity island associated with typhlocolitis in B6.129-IL10 tm1Cgn mice. Microbes Infect. 10(7):726-33. [PudMed:18538610] experimental
experimental This literature contains experimental investigation