I. Summary

SecReT6 ID	470
Strain	Francisella tularensis subsp. holarctica OSU18
Replicon	chromosome [Browse all T6SS(s) in this replicon]
Accession	NC_008369
Location	102493..123977
Comment
Function	N/A
T6SS Type	Type ii (Type FPI)
Bioinformatics investigation has been performed on this T6SS.

II. T6SS components

Component	PdpA	PdpB	IglE	VgrG	IglF	IglG	IglH	DotU	IglI
Number	1	1	1	1	0	1	1	1	1
Component	IglJ	PdpC	PdpE	IglD	IglC	IglB	IglA	PdpD
Number	1	1	1	1	1	1	1	0

III. genome coordinates of the T6SS gene cluster
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Note
1	FTH_0097	98364..98774 [-], 411	115314056	hypothetical protein
2	FTH_0098	98795..99187 [-], 393	115314057	hypothetical protein
3	FTH_0100 (isftu1)	99988..100868 [+], 881	115314058	ISFtu1 transposase
4	FTH_0103 (iglA2)	102493..103083 [+], 591	115314059	intracellular growth locus A protein	IglA
5	FTH_0104 (iglB2)	103073..104617 [+], 1545	115314060	intracellular growth locus B protein	IglB
6	FTH_0105 (iglC2)	104628..105263 [+], 636	115314061	intracellular growth locus C protein	IglC
7	FTH_0106 (iglD2)	105284..106480 [+], 1197	115314062	intracellular growth locus D protein	IglD
8	FTH_0107	106487..107062 [-], 576	115314063	hypothetical protein	PdpE
9	FTH_0108 (pdpC2)	107080..111066 [-], 3987	115314064	protein PdpC	PdpC
10	FTH_0109	111106..111879 [-], 774	115314065	hypothetical protein	IglJ
11	FTH_0110	111845..112996 [-], 1152	115314066	hypothetical protein	IglI
12	FTH_0111	113018..113641 [-], 624	115314067	hypothetical protein	DotU
13	FTH_0112	113654..115084 [-], 1431	115314068	hypothetical protein	IglH
14	FTH_0113	115097..115618 [-], 522	115314069	hypothetical protein	IglG
15	FTH_0115	117355..117849 [-], 495	115314070	hypothetical protein	VgrG
16	FTH_0116	117862..118239 [-], 378	115314071	hypothetical protein	IglE
17	FTH_0117 (pdpB2)	118229..121510 [-], 3282	115314072	protein PdpB	PdpB
18	FTH_0118 (pdpA2)	121515..123977 [-], 2463	115314073	protein PdpA	PdpA

 Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.

1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

Homology Effector list

FTL_0118 , FTT_1347

Effector identified
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Homolog
1	FTH_0110	111845..112996 [-], 1152	115314066	hypothetical protein	FTL_0118
2	FTH_0115	117355..117849 [-], 495	115314070	hypothetical protein	FTT_1347

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Proteins        Genes

N/A

N/A