I. Summary

SecReT6 ID	474
Strain	Francisella tularensis subsp. holarctica FTNF002-00
Replicon	chromosome [Browse all T6SS(s) in this replicon]
Accession	NC_009749
Location	102588..124036
Comment
Function	N/A
T6SS Type	Type ii (Type FPI)
Bioinformatics investigation has been performed on this T6SS.

II. T6SS components

Component	PdpA	PdpB	IglE	VgrG	IglF	IglG	IglH	DotU	IglI
Number	1	1	1	1	0	1	1	1	1
Component	IglJ	PdpC	PdpE	IglD	IglC	IglB	IglA	PdpD
Number	1	1	1	1	1	1	1	0

III. genome coordinates of the T6SS gene cluster
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Note
1	FTA_0111	98422..98832 [-], 411	156501480	hypothetical protein
2	FTA_0112	98853..99245 [-], 393	156501481	lipoprotein
3	FTA_0114	100047..100927 [+], 881	169656484	transposase ISFTu1
4	FTA_0116	100928..101800 [-], 873	156501485	major facilitator transporter
5	FTA_0119 (iglA1)	102588..103142 [+], 555	156501488	intracellular growth locus subunit A	IglA
6	FTA_0120 (iglB1)	103156..104676 [+], 1521	156501489	intracellular growth locus subunit B	IglB
7	FTA_0121 (iglC1)	104687..105322 [+], 636	156501490	intracellular growth locus subunit C	IglC
8	FTA_0122 (iglD1)	105343..106539 [+], 1197	156501491	intracellular growth locus subunit D	IglD
9	FTA_0123	106546..107121 [-], 576	156501492	hypothetical protein	PdpE
10	FTA_0124 (pdpC1)	107139..111125 [-], 3987	156501493	pathogenicity determinant protein PdpC	PdpC
11	FTA_0125	111165..111938 [-], 774	156501494	hypothetical protein	IglJ
12	FTA_0126	111904..113055 [-], 1152	156501495	hypothetical protein	IglI
13	FTA_0127	113077..113700 [-], 624	156501496	hypothetical protein	DotU
14	FTA_0128	113713..115143 [-], 1431	156501497	hypothetical protein	IglH
15	FTA_0129	115156..115677 [-], 522	169656485	hypothetical protein	IglG
16	FTA_0131	117414..117908 [-], 495	156501500	hypothetical protein	VgrG
17	FTA_0132	117921..118298 [-], 378	156501501	lipoprotein	IglE
18	FTA_0133 (pdpB1)	118288..121569 [-], 3282	156501502	pathogenicity deteminant protein PdpB	PdpB
19	FTA_0134 (pdpA1)	121574..124036 [-], 2463	156501503	pathogenicity deteminant protein PdpA	PdpA

 Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.

1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

Homology Effector list

FTL_0118 , FTT_1347

Effector identified
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Homolog
1	FTA_0126	111904..113055 [-], 1152	156501495	hypothetical protein	FTL_0118
2	FTA_0131	117414..117908 [-], 495	156501500	hypothetical protein	FTT_1347

Download FASTA format files

Proteins        Genes

N/A

N/A