I. Summary

SecReT6 ID	478
Strain	Francisella tularensis subsp. mediasiatica FSC147
Replicon	chromosome [Browse all T6SS(s) in this replicon]
Accession	NC_010677
Location	1825027..1850281
Comment
Function	N/A
T6SS Type	Type ii (Type FPI)
Bioinformatics investigation has been performed on this T6SS.

II. T6SS components

Component	PdpA	PdpB	IglE	VgrG	IglF	IglG	IglH	DotU	IglI
Number	1	1	1	1	1	1	1	1	1
Component	IglJ	PdpC	PdpE	IglD	IglC	IglB	IglA	PdpD
Number	1	1	1	1	1	1	1	1

III. genome coordinates of the T6SS gene cluster
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Note
1	FTM_1696 (pdpA2)	1825027..1827489 [+], 2463	187932273	hypothetical protein	PdpA
2	FTM_1697 (pdpB2)	1827494..1830775 [+], 3282	187932274	hypothetical protein	PdpB
3	FTM_1698	1830765..1831142 [+], 378	187932275	lipoprotein	IglE
4	FTM_1699	1831155..1831649 [+], 495	187932276	hypothetical protein	VgrG
5	FTM_1700	1831654..1833318 [+], 1665	187932277	hypothetical protein	IglF
6	FTM_1701	1833386..1833907 [+], 522	187932278	hypothetical protein	IglG
7	FTM_1702	1833920..1835350 [+], 1431	187932279	hypothetical protein	IglH
8	FTM_1703	1835363..1835980 [+], 618	187932280	hypothetical protein	DotU
9	FTM_1704	1836002..1837153 [+], 1152	187932281	hypothetical protein	IglI
10	FTM_1705	1837119..1837892 [+], 774	187932282	hypothetical protein	IglJ
11	FTM_1706 (pdpC2)	1837932..1841918 [+], 3987	187932283	PdpC	PdpC
12	FTM_1707	1841936..1842511 [+], 576	187932284	hypothetical protein	PdpE
13	FTM_1708 (iglD2)	1842518..1843714 [-], 1197	187932285	intracellular growth locus protein D	IglD
14	FTM_1709 (iglC2)	1843735..1844364 [-], 630	187932286	intracellular growth locus protein C	IglC
15	FTM_1710 (iglB2)	1844381..1845901 [-], 1521	187932287	intracellular growth locus protein B	IglB
16	FTM_1711 (iglA2)	1845915..1846469 [-], 555	187932288	intracellular growth locus protein A	IglA
17	FTM_1712 (pdpD2)	1846550..1850281 [-], 3732	187932289	hypothetical protein	PdpD
18	FTM_1716	1853681..1854889 [+], 1209	187932290	metabolite:H+ symporter (MHS) family protein

 Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.

1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

Homology Effector list

FTT_1347 , FTL_0118

Effector identified
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Homolog
1	FTM_1699	1831155..1831649 [+], 495	187932276	hypothetical protein	FTT_1347
2	FTM_1704	1836002..1837153 [+], 1152	187932281	hypothetical protein	FTL_0118

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Proteins        Genes

N/A

N/A