I. Summary

SecReT6 ID	485
Strain	Escherichia coli 042
Replicon	chromosome [Browse all T6SS(s) in this replicon]
Accession	NC_017626
Location	243529..266516
Comment
Function	N/A
T6SS Type	Type i; subtype i1
Bioinformatics investigation has been performed on this T6SS.

II. T6SS components

Component	TssH	TssD	TssL	TssI	TssA	TssB	TssC	TssE	TssF
Number	1	2	1	1	2	1	1	1	1
Component	TssG	TssJ	TssK	TssM
Number	1	1	1	1

III. genome coordinates of the T6SS gene cluster
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Note
1	EC042_RS01110 (gloB)	239097..239852 [-], 756	446975480	hydroxyacylglutathione hydrolase
2	EC042_RS01115	239886..240608 [+], 723	481023496	class I SAM-dependent methyltransferase
3	EC042_RS01120 (rnhA)	240605..241072 [-], 468	446840627	ribonuclease HI
4	EC042_RS01125 (dnaQ)	241137..241868 [+], 732	585203913	DNA polymerase III subunit epsilon
5	EC042_RS01135	242404..243189 [+], 786	447008904	hypothetical protein
6	EC042_RS01140	243529..244008 [-], 480	445935324	Hcp family type VI secretion system effector	TssD
7	EC042_RS01145	244026..245384 [-], 1359	445995948	type VI secretion system ImpA family N-terminal domain-containing protein	TssA
8	EC042_RS01150 (tssM)	245395..248832 [-], 3438	1511003915	type VI secretion system membrane subunit TssM
9	EC042_RS01155 (tssA)	248942..250384 [-], 1443	485665474	type VI secretion system protein TssA	TssA
10	EC042_RS01160 (tagO)	250389..251132 [-], 744	446010989	type VI secretion system-associated protein TagO
11	EC042_RS01165 (tssH)	251129..253861 [-], 2733	446536956	type VI secretion system ATPase TssH	TssH
12	EC042_RS01170 (icmH)	253871..254644 [-], 774	447203013	type IVB secretion system protein IcmH/DotU	TssL
13	EC042_RS01175 (tssK)	254649..255995 [-], 1347	446146658	type VI secretion system baseplate subunit TssK	TssK
14	EC042_RS01180 (tssJ)	255998..256522 [-], 525	446936168	type VI secretion system lipoprotein TssJ	TssJ
15	EC042_RS01185 (tagH)	256519..257811 [-], 1293	446355716	type VI secretion system-associated FHA domain protein TagH	Fha
16	EC042_RS01190 (tssG)	257816..258865 [-], 1050	446819463	type VI secretion system baseplate subunit TssG	TssG
17	EC042_RS01195 (tssF)	258829..260670 [-], 1842	446786139	type VI secretion system baseplate subunit TssF	TssF
18	EC042_RS01200 (tssE)	260676..261101 [-], 426	447112413	type VI secretion system baseplate subunit TssE	TssE
19	EC042_RS01205 (tssC)	261106..262590 [-], 1485	446033725	type VI secretion system contractile sheath large subunit	TssC
20	EC042_RS01210 (tssB)	262613..263116 [-], 504	445963623	type VI secretion system contractile sheath small subunit	TssB
21	EC042_RS01215	263819..264337 [+], 519	447065707	Hcp family type VI secretion system effector	TssD
22	EC042_RS01225 (tssI)	264558..266516 [+], 1959	485665466	type VI secretion system tip protein VgrG	TssI
23	EC042_RS01230	266516..267355 [+], 840	446369142	DUF4123 domain-containing protein
24	EC042_RS01235	267377..268948 [+], 1572	485665464	hypothetical protein
25	EC042_RS01240	269063..270025 [+], 963	446458613	hypothetical protein
26	EC042_RS01245	270338..271261 [+], 924	pseudogene	ISAs1 family transposase

 Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.

1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

Homology Effector list

ABG57132

Effector identified
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Homolog

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Proteins        Genes

N/A

(1) Chaudhuri RR et al. (2010). Complete genome sequence and comparative metabolic profiling of the prototypical enteroaggregative Escherichia coli strain 042. PLoS One. 5(1):e8801. [PudMed:20098708]

This literature contains bioinformatics investigation