I. Summary
SecReT6 ID487 insolico
StrainVibrio cholerae O395
Repliconchromosome II [Browse all T6SS(s) in this replicon]
insolico Bioinformatics investigation has been performed on this T6SS.

II. T6SS components
III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1VC395_A0097 (rluA-2)112722..114401 [-], 1680227119285ribosomal large subunit pseudouridine synthase A 
2VC395_A0098115173..115457 [+], 285227119286hypothetical protein  PAAR
3VC395_A0099115372..116445 [+], 1074227119287hypothetical protein 
4VC395_A0101117425..118903 [+], 1479227119288hypothetical protein  TssC
5VC395_A0102118906..119331 [+], 426227119289hypothetical protein  TssE
6VC395_A0103119337..121106 [+], 1770227119290hypothetical protein  TssF
7VC395_A0104121070..122086 [+], 1017227119291hypothetical protein  TssG
8VC395_A0105122089..123576 [+], 1488227119292hypothetical protein  Fha
9VC395_A0106123579..124055 [+], 477227119293hypothetical protein  TssJ
10VC395_A0108125401..126174 [+], 774227119294hypothetical protein  TssL
11VC395_A0109 (clpB-2)126200..128809 [+], 2610227119295clpB protein  TssH
12VC395_A0110128812..130404 [+], 1593227119296sigma-54 dependent transcriptional regulator  VasH
13VC395_A0111130374..131057 [+], 684227119297hypothetical protein  VCA0118
14VC395_A0112131067..132476 [+], 1410227119298hypothetical protein  TssA
15VC395_A0114136077..137342 [+], 1266227119299hypothetical protein  TssA
16VC395_A0115137393..137635 [+], 243227119300hypothetical protein 
17VC395_A0116 (vgrG-3)137595..140648 [+], 3054227119301vgrG protein  TssI
18VC395_A0117140645..141013 [+], 369227119302hypothetical protein  TsiV3 (i)
19VC395_A0118141161..141421 [-], 261227119303hypothetical protein 
20VC395_A0119141396..141605 [+], 210227119304hypothetical protein 
21VC395_A0120 (rbsD)141654..142124 [+], 471227119305ribose ABC transporter protein 
22VC395_A0121 (rbsA)142151..143653 [+], 1503227119306ribose ABC transporter, ATP-binding protein 
23VC395_A0122 (rbsC)143650..144651 [+], 1002227119307ribose ABC transporter, permease protein 
24VC395_A0123 (rbsB)144706..145590 [+], 885227119308ribose ABC transporter, periplasmic D-ribose-binding protein 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

Homology Effector list
VCA0017 , VC1416, VC1418, VCA0017, VCA0018, VCA0020, VCA0118, VCA0123, VCA0285

Effector identified
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1VC395_1534(hcp-1)1599520..1600038 [+], 519227117880hcp protein VCA0017
2VC395_1535(vgrG-1)1600166..1603453 [+], 3288227117881vgrG protein VC1416
3VC395_15371604451..1606376 [+], 1926227117883hypothetical protein VC1418
4VC395_A0014(hcp-2)19781..20299 [+], 519227119202hcp protein VCA0017
5VC395_A0015(vgrG-2)20427..22511 [+], 2085227119203vgrG protein VCA0018
6VC395_A001723395..26652 [+], 3258227119205hypothetical protein VCA0020
7VC395_A0111130374..131057 [+], 684227119297hypothetical protein VCA0118
8VC395_A0116(vgrG-3)137595..140648 [+], 3054227119301vgrG protein VCA0123
9VC395_A0322340069..340740 [+], 672227119503hypothetical protein VCA0285

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Proteins        Genes

Homology Immunity protein list
VC1419, VCA0021, VCA0124, VCA0286

Immunity protein identified
#Locus tag(Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1VC395_15381606373..1607116 [+], 744227117884hypothetical protein VC1419
2VC395_A001826653..27381 [+], 729227119206hypothetical protein VCA0021
3VC395_A0117140645..141013 [+], 369227119302hypothetical protein VCA0124
4VC395_A0323340742..341092 [+], 351227119504hypothetical protein VCA0286

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Proteins        Genes