I. Summary

SecReT6 ID	550
Strain	Salmonella enterica subsp. enterica serovar Typhimurium str. D23580
Replicon	chromosome [Browse all T6SS(s) in this replicon]
Accession	NC_016854
Location	304651..332033
Comment
Function	N/A
T6SS Type	Type i; subtype i3
Bioinformatics investigation has been performed on this T6SS.

II. T6SS components

Component	TssH	TssD	TssL	TssI	TssA	TssB	TssC	TssE	TssF
Number	1	2	1	1	1	1	1	1	1
Component	TssG	TssJ	TssK	TssM
Number	1	1	1	1

III. genome coordinates of the T6SS gene cluster
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Note
1	STMMW_02591	299910..301277 [-], 1368	378443706	membrane-bound lytic murein transglycosylase D
2	STMMW_02601	301349..302104 [-], 756	378443707	hydroxyacylglutathione hydrolase
3	STMMW_02611	302139..302861 [+], 723	378443708	hypothetical protein
4	STMMW_02621	302858..303325 [-], 468	378443709	RNase H
5	STMMW_02631	303389..304120 [+], 732	378443710	DNA polymerase III epsilon subunit
6	STMMW_02641	304651..305706 [-], 1056	378443711	pathogenicity island protein	TssA
7	STMMW_02651	305717..306712 [-], 996	378443712	type VI secretion protein	TssG
8	STMMW_02661	306709..308592 [-], 1884	378443713	type VI system protein	TssF
9	STMMW_02671	308608..309102 [-], 495	378443714	putative type VI system cytoplasmic protein	TssE
10	STMMW_02691	309099..309923 [-], 825	378443715	putative type VI secretion system protein	TagJ
11	STMMW_02701	309910..310812 [-], 903	378443716	hypothetical protein
12	STMMW_02711	311180..313819 [+], 2640	378443717	type VI system ATPase	TssH
13	STMMW_02731	313919..314461 [+], 543	378443718	putative type VI secretion system protein	TssB
14	STMMW_02741	314485..315978 [+], 1494	378443719	type VI system secreted protein	TssC
15	STMMW_02751	316041..316151 [+], 111	378443720	invasol
16	STMMW_02771	316164..316610 [+], 447	378443721	hypothetical protein
17	STMMW_02791	316864..317349 [+], 486	378443722	putative hemolysin-coregulated protein	TssD
18	STMMW_02811	317654..318139 [+], 486	378443723	hypothetical protein	STM0277 (e)
19	STMMW_02831	318124..318507 [+], 384	378443724	hypothetical protein	STM0278 (i)
20	STMMW_02841	318650..319135 [+], 486	378443725	putative hemolysin-coregulated protein	TssD
21	STMMW_02851	319202..319738 [+], 537	378443726	putative lipoprotein	TssJ
22	STMMW_02861	319742..321085 [+], 1344	378443727	putative type VI secretion protein	TssK
23	STMMW_02871	321082..322386 [+], 1305	378443728	putative type VI system protein	TssL
24	STMMW_02881	322391..323164 [+], 774	378443729	putative inner membrane protein
25	STMMW_02891	323355..323798 [+], 444	378443730	putative shiga-like toxin A subunit
26	STMMW_02901	323832..327701 [+], 3870	378443731	type VI system protein	TssM
27	STMMW_02911	327701..328489 [+], 789	378443732	hypothetical protein
28	STMMW_02921	328486..328902 [+], 417	378443733	hypothetical protein
29	STMMW_02931	328926..329447 [+], 522	378443734	pathogenicity island protein
30	STMMW_02941	329844..332033 [+], 2190	378443735	putative type VI system protein	TssI
31	STMMW_02951	332057..332503 [+], 447	378443736	hypothetical protein
32	STMMW_02961	332522..336616 [+], 4095	378443737	putative Rhs family protein	PAAR
33	STMMW_02971	336610..336873 [+], 264	378443738	hypothetical protein

 Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.

1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

Homology Effector list

SciK , STM0277, SciK, STY2606, Hcp

Effector identified
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Homolog
1	STMMW_02791	316864..317349 [+], 486	378443722	putative hemolysin-coregulated protein	SciK
2	STMMW_02811	317654..318139 [+], 486	378443723	hypothetical protein	STM0277
3	STMMW_02841	318650..319135 [+], 486	378443725	putative hemolysin-coregulated protein	SciK
4	STMMW_23971	2510581..2510949 [+], 369	378445802	hypothetical protein	STY2606
5	STMMW_30911	3282213..3282698 [-], 486	378446482	hypothetical protein	Hcp

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Proteins        Genes

Homology Immunity protein list

STM0278, STY2607

Immunity protein identified
#	Locus tag(Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Homolog
1	STMMW_02831	318124..318507 [+], 384	378443724	hypothetical protein	STM0278
2	STMMW_23981	2510949..2511467 [+], 519	378445803	putative lipoprotein	STY2607

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Proteins        Genes

N/A