I. Summary
SecReT6 ID557 insolico
StrainVibrio cholerae IEC224
Repliconchromosome II [Browse all T6SS(s) in this replicon]
T6SS TypeType i; subtype i1
insolico Bioinformatics investigation has been performed on this T6SS.

II. T6SS components
III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1O3Y_13958112678..114390 [-], 1713379743550ribosomal large subunit pseudouridine synthase A 
2O3Y_13963115130..115414 [+], 285379743551hypothetical protein  PAAR
3O3Y_13968115398..116402 [+], 1005379743552hypothetical protein 
4O3Y_13973116834..117340 [+], 507379743553type VI secretion system protein ImpB  TssB
5O3Y_13978117384..118859 [+], 1476379743554type VI secretion system protein ImpC  TssC
6O3Y_13983118862..119299 [+], 438379743555type VI secretion system protein  TssE
7O3Y_13988119305..121074 [+], 1770379743556type VI secretion system protein ImpG  TssF
8O3Y_13993121038..122054 [+], 1017379743557type VI secretion system protein ImpH  TssG
9O3Y_13998122057..123544 [+], 1488379743558type VI secretion system protein ImpI  Fha
10O3Y_14003123547..124023 [+], 477379743559type VI secretion system protein VasD  TssJ
11O3Y_14008124030..125364 [+], 1335379743560type VI secretion system protein ImpJ  TssK
12O3Y_14013125367..126140 [+], 774379743561type VI secretion system protein ImpK  TssL
13O3Y_14018126166..128775 [+], 2610379743562type VI secretion system protein VasG  TssH
14O3Y_14023128778..130370 [+], 1593379743563sigma-54 dependent transcriptional regulator  VasH
15O3Y_14028130367..131023 [+], 657379743564type VI secretion system protein VasI  VCA0118
16O3Y_14033131033..132442 [+], 1410379743565type VI secretion system protein VasJ  TssA
17O3Y_14038132503..136003 [+], 3501379743566type VI secretion system protein ImpL  TssM
18O3Y_14043136054..137316 [+], 1263379743567hypothetical protein  TssA
19O3Y_14048137367..137609 [+], 243379743568hypothetical protein 
20O3Y_14053137569..140622 [+], 3054379743569VgrG protein  TssI
21O3Y_14058140619..140987 [+], 369379743570hypothetical protein  TsiV3 (i)
22O3Y_14063141129..141389 [-], 261379743571hypothetical protein 
23O3Y_14068141673..142092 [+], 420379743572D-ribose pyranase 
24O3Y_14073142119..143621 [+], 1503379743573D-ribose transporter ATP-binding protein 
25O3Y_14078 (rbsC)143651..144619 [+], 969379743574ribose ABC transporter permease 
26O3Y_14083144674..145558 [+], 885379743575D-ribose transporter subunit RbsB 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

Homology Effector list
VCA0017 , VC1416, VC1418, VCA0017, VCA0018, VCA0020, VCA0118, VCA0123, VCA0285

Effector identified
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1O3Y_065601506660..1507178 [+], 519379741209hcp protein VCA0017
2O3Y_065651507306..1510797 [+], 3492379741210type VI secretion system secreted protein VgrG VC1416
3O3Y_065751511639..1513564 [+], 1926379741212hypothetical protein VC1418
4O3Y_1357319780..20298 [+], 519379743473hcp protein VCA0017
5O3Y_1357820426..22510 [+], 2085379743474type VI secretion system secreted protein VgrG VCA0018
6O3Y_1358823394..26651 [+], 3258379743476hypothetical protein VCA0020
7O3Y_14028130367..131023 [+], 657379743564type VI secretion system protein VasI VCA0118
8O3Y_14053137569..140622 [+], 3054379743569VgrG protein VCA0123
9O3Y_14793305167..305838 [+], 672379743715hypothetical protein VCA0285

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Proteins        Genes

Homology Immunity protein list
VC1419, VCA0021, VCA0124, VCA0286

Immunity protein identified
#Locus tag(Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1O3Y_065801513561..1514304 [+], 744379741213hypothetical protein VC1419
2O3Y_1359326652..27380 [+], 729379743477hypothetical protein VCA0021
3O3Y_14058140619..140987 [+], 369379743570hypothetical protein VCA0124
4O3Y_14798305840..306190 [+], 351379743716hypothetical protein VCA0286

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Proteins        Genes