I. Summary
SecReT6 ID6 insolico
StrainEscherichia coli O157:H7 str. EDL933
Repliconchromosome [Browse all T6SS(s) in this replicon]
T6SS TypeType i; subtype i1
insolico Bioinformatics investigation has been performed on this T6SS.

II. T6SS components
III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1Z0232 (yafD)234452..235252 [+], 80115799885hypothetical protein 
2Z0233235330..236100 [+], 77115799886hypothetical protein 
3Z0235 (mltD)236148..237506 [-], 135915799887membrane-bound lytic murein transglycosylase D 
4Z0236 (gloB)237578..238333 [-], 75615799888hydroxyacylglutathione hydrolase 
5Z0237 (yafS)238349..239089 [+], 74115799889hypothetical protein 
6Z0239 (rnhA)239086..239553 [-], 46815799890ribonuclease H 
7Z0241 (dnaQ)239618..240349 [+], 73215799891DNA polymerase III subunit epsilon 
8Z0243240887..241687 [+], 80115799892hypothetical protein 
9Z0244241872..242168 [-], 29715799893hypothetical protein 
10Z0245242165..242620 [-], 45615799894hypothetical protein 
11Z0246242617..243213 [-], 59715799895hypothetical protein 
12Z0247243292..243513 [-], 22215799896hypothetical protein 
13Z0248243534..244013 [-], 48015799897hypothetical protein  TssD
14Z0249243979..245478 [-], 150015799898hypothetical protein  TssA
15Z0250245399..248833 [-], 343515799899macrophage toxin  TssM
16Z0251248970..249764 [-], 79515799900hypothetical protein  TssA
17Z0252249761..250381 [-], 62115799901hypothetical protein 
18Z0253250386..251129 [-], 74415799902hypothetical protein 
19Z0254251126..253897 [-], 277215799903protease  TssH
20Z0255253906..254667 [-], 76215799904hypothetical protein  TssL
21Z0256254672..256003 [-], 133215799905hypothetical protein  TssK
22Z0257256006..256530 [-], 52515799906hypothetical protein  TssJ
23Z0258256527..257828 [-], 130215799907hypothetical protein  Fha
24Z0259257832..258914 [-], 108315799908hypothetical protein  TssG
25Z0260258878..260728 [-], 185115799909hypothetical protein  TssF
26Z0261260732..261145 [-], 41415799910hypothetical protein  TssE
27Z0262261236..262627 [-], 139215799911hypothetical protein  TssC
28Z0263262678..262902 [-], 22515799912hypothetical protein 
29Z0264262937..263437 [-], 50115799913hypothetical protein  TssB
30Z0265263864..264007 [+], 14415799914hypothetical protein 
31Z0266264134..264652 [+], 51915799915hypothetical protein  TssD
32Z0267264862..267003 [+], 214215799916hypothetical protein  TssI
33Z0268267079..271293 [+], 421515799917hypothetical protein  PAAR
34Z0269271296..271907 [+], 61215799918hypothetical protein 
35Z0271272653..273789 [+], 113715799919hypothetical protein 
36Z0272273792..275552 [+], 176115799920hypothetical protein 
37Z0273275640..275777 [-], 13815799921hypothetical protein 
38Z0274275754..276017 [+], 26415799922hypothetical protein 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

Homology Effector list
ECA4275 , Z1921, Z5014

Effector identified
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1Z0266264134..264652 [+], 51915799915hypothetical protein ECA4275
2Z19211744916..1745806 [-], 89115801381hypothetical protein Z1921
3Z5014(rhsA)4572113..4576246 [+], 413415804134rhsA protein in rhs element Z5014
Data from experimental literature

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Proteins        Genes
The information on regulator interaction.

#homolog effector locus tagRegulator wayFunctionRegulate targetDescription
1Z4049 (RpoS)Transcription regulator+Z1921 (KatN)RpoS was essential for katN transcription in an uncertian way.
2Z5519 (OxyR)Transcription regulator+Z1921 (KatN)OxyR promoted the transcription of katN in an uncertian way.
3Z2013 (hns)Transcription regulator-Z0264 (hcp-2)The T6SS of EHEC is repressed by H-NS in an uncertian way.
(1) Boyer F et al. (2009). Dissecting the bacterial type VI secretion system by a genome wide in silico analysis: what can be learned from available microbial genomic resources. BMC Genomics. 10:104. [PudMed:19284603] in_silico
in_silico This literature contains bioinformatics investigation