I. Summary
SecReT6 ID61 experimental
StrainAcinetobacter sp. ADP1
Repliconchromosome [Browse all T6SS(s) in this replicon]
Functioneffector translocation
T6SS TypeType i; subtype i4b
experimental Experimental investigation has been performed on this T6SS.

II. T6SS components
III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1ACIAD26742628937..2629482 [-], 54650085741electron transfer flavoprotein 
2ACIAD26752629502..2630743 [-], 124250085742oxygenase subunit protein 
3ACIAD26762630795..2631646 [-], 85250085743short chain dehydrogenase 
4ACIAD26772631616..2632899 [-], 128450085744dienelactone hydrolase 
5ACIAD26782633143..2634144 [-], 100250085745transcriptional regulator 
6ACIAD2680 (gdh)2634401..2635672 [-], 127250085746glutamate dehydrogenase (NAD(P)+) oxidoreductase protein 
7ACIAD26812635901..2636167 [-], 26750085747hypothetical protein  PAAR
8ACIAD26822636197..2636961 [-], 76550085748outer membrane lipoprotein  TagL
9ACIAD26832636964..2637923 [-], 96050085749hypothetical protein 
10ACIAD26842637964..2641785 [-], 382250085750hypothetical protein  TssM
11ACIAD26852641820..2643250 [-], 143150085751hypothetical protein 
12ACIAD26862643220..2644218 [-], 99950085752hypothetical protein  TssG
13ACIAD26872644182..2645990 [-], 180950085753hypothetical protein  TssF
14ACIAD26882646002..2646475 [-], 47450085754hypothetical protein  TssE
15ACIAD26892646545..2647048 [-], 50450085755hypothetical protein  TssD
16ACIAD26902647094..2648590 [-], 149750085756hypothetical protein  TssC
17ACIAD26912648568..2649077 [-], 51050085757hypothetical protein  TssB
18ACIAD26932649091..2649747 [-], 65750085758hypothetical protein 
19ACIAD26942650125..2652809 [+], 268550085759ClpA/B-type chaperone  TssH
20ACIAD26952652825..2653928 [+], 110450085760hypothetical protein  TssA
21ACIAD26962653945..2655312 [+], 136850085761hypothetical protein  TssK
22ACIAD26972655324..2656127 [+], 80450085762hypothetical protein  TssL
23ACIAD26982656138..2656719 [+], 58250085763hypothetical protein 
24ACIAD26992656820..2657683 [+], 86450085764hypothetical protein 
25ACIAD27002657701..2658882 [-], 118250085765hypothetical protein 
26ACIAD27012659669..2660025 [+], 35750085766hypothetical protein 
27ACIAD27022660030..2660530 [+], 50150085767hypothetical protein 
28ACIAD27042660893..2661510 [+], 61850085768hypothetical protein 
29ACIAD27052661512..2661904 [+], 39350085769hypothetical protein 
30ACIAD27072662166..2662330 [+], 16550085770hypothetical protein 
31ACIAD27082662359..2663201 [+], 84350085771hypothetical protein 
32ACIAD27092663226..2663423 [+], 19850085772hypothetical protein 
33ACIAD27102663420..2663560 [+], 14150085773hypothetical protein 
34ACIAD27112663658..2664314 [+], 65750085774hypothetical protein 
35ACIAD27122664311..2664601 [+], 29150085775hypothetical protein 
36ACIAD27132664856..2665167 [+], 31250085776hypothetical protein 
37ACIAD27142665176..2665442 [+], 26750085777hypothetical protein 
38ACIAD27152665640..2665873 [+], 23450085778hypothetical protein 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

Homology Effector list
ACIAD0053 , ACIAD0168, A1S_1296, ACIAD3114, ACIAD3425, ACIAD1790–1794 fusion

Effector identified
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1ACIAD005355985..56617 [+], 63350083347zinc protease ACIAD0053
2ACIAD0168170197..172380 [+], 218450083453hypothetical protein ACIAD0168
3ACIAD26892646545..2647048 [-], 50450085755hypothetical protein A1S_1296
4ACIAD31143040392..3043397 [-], 300650086118hypothetical protein ACIAD3114
5ACIAD34253339596..3341326 [-], 173150086393hypothetical protein ACIAD3425
Data from experimental literature

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Proteins        Genes

Homology Immunity protein list
ACIAD0054, ACIAD0169, ACIAD1795, ACIAD1796, ACIAD3112, ACIAD3113, ACIAD3426

Immunity protein identified
#Locus tag(Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1ACIAD005456618..57070 [+], 45350083348hypothetical protein ACIAD0054
2ACIAD0169172382..173107 [+], 72650083454hypothetical protein ACIAD0169
3ACIAD17951802446..1803534 [+], 108950084943hypothetical protein ACIAD1795
4ACIAD17961803547..1804635 [+], 108950084944hypothetical protein ACIAD1796
5ACIAD31123038267..3039250 [+], 98450086116hypothetical protein ACIAD3112
6ACIAD31133039389..3040372 [+], 98450086117hypothetical protein ACIAD3113
7ACIAD34263341328..3342386 [-], 105950086394hypothetical protein ACIAD3426
Data from experimental literature

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Proteins        Genes

Adaptors list
ACIAD2685, TagX

Adaptor identified
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1ACIAD26852641820..2643250 [-], 143150085751hypothetical protein ACIAD2685
Data from experimental literature

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Proteins        Genes
(1) Shneider MM et al. (2013). PAAR-repeat proteins sharpen and diversify the type VI secretion system spike. Nature. 500(7462):350-3. [PudMed:23925114] experimental in_silico
(2) Basler M et al. (2013). Tit-for-Tat: Type VI Secretion System Counterattack during Bacterial Cell-Cell Interactions. Cell. 152(4):884-94. [PudMed:23415234] experimental
(3) Weber BS et al. (2013). Genomic and Functional Analysis of the Type VI Secretion System in Acinetobacter. PLoS One. 8(1):e55142. [PudMed:23365692] experimental
(4) Boyer F et al. (2009). Dissecting the bacterial type VI secretion system by a genome wide in silico analysis: what can be learned from available microbial genomic resources. BMC Genomics. 10:104. [PudMed:19284603] in_silico
experimental This literature contains experimental investigation
in_silico This literature contains bioinformatics investigation