I. Summary
SecReT6 ID61 experimental
StrainAcinetobacter sp. ADP1
Repliconchromosome [Browse all T6SS(s) in this replicon]
Functioneffector translocation
T6SS TypeType i; subtype i4b
experimental Experimental investigation has been performed on this T6SS.

II. T6SS components
III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1ACIAD_RS121602628937..2629467 [-], 531648275822flavin reductase family protein 
2ACIAD_RS121652629502..2630740 [-], 1239491067333hypothetical protein 
3ACIAD_RS121702630795..2631586 [-], 792491067336SDR family oxidoreductase 
4ACIAD_RS121752631616..2632863 [-], 1248491067339dienelactone hydrolase family protein 
5ACIAD_RS121802633143..2634144 [-], 1002491067341AraC family transcriptional regulator 
6ACIAD_RS121852634401..2635675 [-], 12751842240247Glu/Leu/Phe/Val dehydrogenase 
7ACIAD_RS121902635901..2636167 [-], 267491067346PAAR domain-containing protein 
8ACIAD_RS121952636197..2636961 [-], 765491067348OmpA family protein 
9ACIAD_RS12200 (tagF)2636964..2637923 [-], 960491067356type VI secretion system-associated protein TagF 
10ACIAD_RS12205 (tssM)2637964..2641785 [-], 3822491067362type VI secretion system membrane subunit TssM 
11ACIAD_RS122102641820..2643223 [-], 1404491067366hypothetical protein 
12ACIAD_RS12215 (tssG)2643220..2644218 [-], 999491067368type VI secretion system baseplate subunit TssG 
13ACIAD_RS12220 (tssF)2644182..2645990 [-], 1809491067370type VI secretion system baseplate subunit TssF 
14ACIAD_RS12225 (tssE)2646002..2646475 [-], 474491067373type VI secretion system baseplate subunit TssE 
15ACIAD_RS122302646545..2647048 [-], 504491067376type VI secretion system tube protein Hcp 
16ACIAD_RS12235 (tssC)2647094..2648575 [-], 1482491067380type VI secretion system contractile sheath large subunit 
17ACIAD_RS12240 (tssB)2648568..2649071 [-], 504491067383type VI secretion system contractile sheath small subunit 
18ACIAD_RS122452649091..2649747 [-], 657491067385hypothetical protein 
19ACIAD_RS12250 (tssH)2650134..2652809 [+], 26761279672583type VI secretion system ATPase TssH 
20ACIAD_RS12255 (tssA)2652825..2653928 [+], 1104491067390type VI secretion system protein TssA 
21ACIAD_RS12260 (tssK)2653945..2655312 [+], 1368491067393type VI secretion system baseplate subunit TssK 
22ACIAD_RS122652655324..2656127 [+], 804491067397type IVB secretion system protein IcmH/DotU 
23ACIAD_RS122702656138..2656719 [+], 582491067400hypothetical protein 
24ACIAD_RS122752656730..2657683 [+], 954648275820M15 family metallopeptidase 
25ACIAD_RS12280 (prpF)2657701..2658882 [-], 11824910674042-methylaconitate cis-trans isomerase PrpF 
26ACIAD_RS122852659669..2660025 [+], 357491067407hypothetical protein 
27ACIAD_RS122902660030..2660530 [+], 501491067410hypothetical protein 
28ACIAD_RS122952660893..2661510 [+], 618491067416hypothetical protein 
29ACIAD_RS123002661512..2661904 [+], 393491067418hypothetical protein 
30ACIAD_RS123052662359..2663201 [+], 843491067421hypothetical protein 
31ACIAD_RS123102663226..2663423 [+], 198499495953hypothetical protein 
32ACIAD_RS123152663658..2664314 [+], 657491067427hypothetical protein 
33ACIAD_RS123252664856..2665167 [+], 312491067434hypothetical protein 
34ACIAD_RS123302665176..2665442 [+], 267499495954hypothetical protein 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

Homology Effector list
ACIAD0053 , ACIAD0168, A1S_1296, ACIAD3114, ACIAD3425, ACIAD1790–1794 fusion

Effector identified
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog

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Proteins        Genes

Homology Immunity protein list
ACIAD0054, ACIAD0169, ACIAD1795, ACIAD1796, ACIAD3112, ACIAD3113, ACIAD3426

Immunity protein identified
#Locus tag(Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog

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Proteins        Genes

Adaptors list
ACIAD2685, TagX

Adaptor identified
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog

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Proteins        Genes
(1) Shneider MM et al. (2013). PAAR-repeat proteins sharpen and diversify the type VI secretion system spike. Nature. 500(7462):350-3. [PudMed:23925114] experimental in_silico
(2) Basler M et al. (2013). Tit-for-Tat: Type VI Secretion System Counterattack during Bacterial Cell-Cell Interactions. Cell. 152(4):884-94. [PudMed:23415234] experimental
(3) Weber BS et al. (2013). Genomic and Functional Analysis of the Type VI Secretion System in Acinetobacter. PLoS One. 8(1):e55142. [PudMed:23365692] experimental
(4) Boyer F et al. (2009). Dissecting the bacterial type VI secretion system by a genome wide in silico analysis: what can be learned from available microbial genomic resources. BMC Genomics. 10:104. [PudMed:19284603] in_silico
experimental This literature contains experimental investigation
in_silico This literature contains bioinformatics investigation