SecReT6
I. Summary
SecReT6 ID612 insolico
StrainPseudomonas aeruginosa M18
Repliconchromosome [Browse all T6SS(s) in this replicon]
AccessionNC_017548
Location2967324..2986402
Comment
FunctionN/A
T6SS TypeType i; subtype i4a
insolico Bioinformatics investigation has been performed on this T6SS.

II. T6SS components
ComponentTssHTssDTssLTssITssATssBTssCTssETssF
Number111111111
ComponentTssGTssJTssKTssM
Number1011
III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1PAM18_26642964035..2965309 [-], 1275386058727putative ABC-type transport protein, periplasmic component 
2PAM18_26652965441..2966082 [-], 642386058728putative transcriptional regulator 
3PAM18_26662966359..2966754 [+], 396386058729hypothetical protein 
4PAM18_26672966777..2967313 [-], 537386058730hypothetical protein 
5PAM18_26682967324..2969330 [-], 2007386058731hypothetical protein  TssI
6PAM18_26692969678..2970250 [-], 573386058732hypothetical protein 
7PAM18_26702970272..2972821 [-], 2550386058733putative ClpA/B-type protease  TssH
8PAM18_26712972823..2973839 [-], 1017386058734hypothetical protein  TssG
9PAM18_26722973803..2975596 [-], 1794386058735hypothetical protein  TssF
10PAM18_26732975580..2976005 [-], 426386058736hypothetical protein  TssE
11PAM18_26742976018..2976515 [-], 498386058737hypothetical protein  TssD
12PAM18_26752976589..2978073 [-], 1485386058738hypothetical protein  TssC
13PAM18_26762978096..2978641 [-], 546386058739hypothetical protein  TssB
14PAM18_26772978850..2979326 [+], 477386058740hypothetical protein 
15PAM18_26782979386..2980717 [+], 1332386058741hypothetical protein  TssK
16PAM18_26792980735..2981493 [+], 759386058742hypothetical protein  TssL
17PAM18_26802981490..2985305 [+], 3816386058743hypothetical protein  TssM
18PAM18_26812985302..2986402 [+], 1101386058744hypothetical protein  TssA
19PAM18_26822986512..2987597 [+], 1086386058745putative transcriptional regulator  Sfa3
20PAM18_26832987833..2988099 [+], 267386058746hypothetical protein 
21PAM18_2684 (msuE)2988259..2988819 [+], 561386058747NADH-dependent FMN reductase MsuE 
22PAM18_2685 (msuD)2988829..2989974 [+], 1146386058748methanesulfonate sulfonatase MsuD 
23PAM18_26862990004..2991188 [+], 1185386058749putative FMNH2-dependent monooxygenase 
 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.
 






2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.
 






3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.
 







Homology Effector list
PA5089

Effector identified
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1PAM18_52035780698..5782935 [-], 2238386061261hypothetical protein PA5089

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Proteins        Genes
N/A
Regulatory element identified
GacA
RegulatorDescriptionReference
GacA (PAM18_2407)ActivatorPMID: 23708134

(1) Wei X et al. (2013). Global control of GacA on secondary metabolism, primary metabolism, secretion systems, and motility in the rhizobacterium Pseudomonas aeruginosa M18. J Bacteriol. 195(15):3387-400. [PudMed:23708134] experimental
 
experimental This literature contains experimental investigation

Genomics & Bioinformatics Group in MML, SJTU