I. Summary

SecReT6 ID	627
Strain	Escherichia coli O83:H1 str. NRG 857C
Replicon	chromosome [Browse all T6SS(s) in this replicon]
Accession	NC_017634
Location	242739..282235
Comment
Function	N/A
T6SS Type	Type i; subtype i1
Bioinformatics investigation has been performed on this T6SS.

II. T6SS components

Component	TssH	TssD	TssL	TssI	TssA	TssB	TssC	TssE	TssF
Number	1	2	1	1	2	1	1	1	1
Component	TssG	TssJ	TssK	TssM
Number	1	1	1	1

III. genome coordinates of the T6SS gene cluster
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Note
1	NRG857_01055	238304..239059 [-], 756	387615554	hydroxyacylglutathione hydrolase
2	NRG857_01060	239093..239815 [+], 723	387615555	putative S-adenosyl-L-methionine-dependent methyltransferase
3	NRG857_01065 (rnhA)	239812..240279 [-], 468	387615556	ribonuclease H
4	NRG857_01070	240344..241075 [+], 732	387615557	DNA polymerase III subunit epsilon
5	NRG857_01075	241614..242399 [+], 786	387615558	putative aminopeptidase
6	NRG857_01080	242739..243218 [-], 480	387615559	hypothetical protein	TssD
7	NRG857_01085	243236..244594 [-], 1359	387615560	hypothetical protein	TssA
8	NRG857_01090	244605..248129 [-], 3525	387615561	IcmF-like protein	TssM
9	NRG857_01095	248149..249591 [-], 1443	387615562	hypothetical protein	TssA
10	NRG857_01100	249596..250339 [-], 744	387615563	hypothetical protein
11	NRG857_01105	250336..253098 [-], 2763	387615564	putative ATP-dependent Clp proteinase Aec27 ATP-binding chain, with chaperone activity	TssH
12	NRG857_01110	253108..253872 [-], 765	387615565	hypothetical protein	TssL
13	NRG857_01115	253877..255223 [-], 1347	387615566	hypothetical protein	TssK
14	NRG857_01120	255226..255750 [-], 525	387615567	hypothetical protein	TssJ
15	NRG857_01125	255747..257039 [-], 1293	387615568	hypothetical protein	Fha
16	NRG857_01130	257044..258093 [-], 1050	387615569	hypothetical protein	TssG
17	NRG857_01135	258057..259898 [-], 1842	387615570	hypothetical protein	TssF
18	NRG857_01140	259904..260329 [-], 426	387615571	hypothetical protein	TssE
19	NRG857_01145	260334..261818 [-], 1485	387615572	hypothetical protein	TssC
20	NRG857_01150	261841..262344 [-], 504	387615573	hypothetical protein	TssB
21	NRG857_01155	263050..263568 [+], 519	387615574	hypothetical protein	TssD
22	NRG857_01160	263663..263773 [+], 111	387615575	hypothetical protein
23	NRG857_01165	263789..265771 [+], 1983	387615576	Vgr-like protein	TssI
24	NRG857_01170	265878..266273 [+], 396	387615577	hypothetical protein
25	NRG857_01180	266918..268357 [+], 1440	387615578	hypothetical protein	PAAR
26	NRG857_01185	268332..268622 [+], 291	387615579	hypothetical protein
27	NRG857_01190	268880..269059 [+], 180	387615580	putative H-repeat associated protein
28	NRG857_01195	269159..269644 [+], 486	387615581	hypothetical protein
29	NRG857_01200	269873..270376 [+], 504	387615582	hypothetical protein
30	NRG857_01205	270446..270958 [+], 513	387615583	hypothetical protein
31	NRG857_01210	271229..271999 [-], 771	387615584	hypothetical protein
32	NRG857_01215	272153..272626 [+], 474	387615585	C-lysozyme inhibitor
33	NRG857_01220 (fadE)	272669..275113 [-], 2445	387615586	acyl-CoA dehydrogenase
34	NRG857_01225 (gmhA)	275353..275931 [+], 579	387615587	phosphoheptose isomerase
35	NRG857_01230	276136..276903 [+], 768	387615588	putative amidotransfease
36	NRG857_01235	276874..277614 [-], 741	387615589	hypothetical protein
37	NRG857_01240	277917..278675 [+], 759	387615590	putative exported hydrolase
38	NRG857_01245	278851..279348 [+], 498	387615591	hypothetical protein
39	NRG857_01250	279766..281505 [-], 1740	387615592	flagellar system protein
40	NRG857_01255	281465..282235 [+], 771	387615593	hypothetical protein	TagL
41	NRG857_01260	282306..283361 [+], 1056	387615594	DNA polymerase IV
42	NRG857_01265	283413..283706 [+], 294	387615595	putative antitoxin of the YafO-YafN toxin-antitoxin system
43	NRG857_01270	283709..284107 [+], 399	387615596	putative toxin YafO
44	NRG857_01275	284117..284569 [+], 453	387615597	hypothetical protein
45	NRG857_01280	284886..286025 [+], 1140	387615598	hypothetical protein
46	NRG857_01285 (prfH)	286022..286636 [+], 615	387615599	peptide chain release factor-like protein

 Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.

1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

Homology Effector list

ABG57132

Effector identified
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Homolog
1	NRG857_01155	263050..263568 [+], 519	387615574	hypothetical protein	ABG57132

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Proteins        Genes

N/A

N/A