I. Summary
SecReT6 ID647 insolico
StrainBurkholderia pseudomallei 1026b
Repliconchromosome II [Browse all T6SS(s) in this replicon]
T6SS TypeType i; subtype i1
insolico Bioinformatics investigation has been performed on this T6SS.

II. T6SS components
III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1BP1026B_II15822000759..2001784 [+], 1026386865270N-acetylmuramoyl-L-alanine amidase domain-containing protein 
2BP1026B_II15832001912..2003312 [+], 1401386865271hypothetical protein 
3BP1026B_II15842003440..2004885 [+], 1446386865272intracellular motility protein A 
4BP1026B_II15852004965..2005342 [+], 378386865273hypothetical protein 
5BP1026B_II1586 (tssA-5)2005585..2007483 [-], 1899386865274type VI secretion system  TssA
6BP1026B_II15872007474..2008157 [-], 684386865275DNA-binding response regulator  VirG
7BP1026B_II15892008208..2010037 [-], 1830386865276sensor histidine kinase  VirA
8BP1026B_II1590 (tssB-5)2010297..2010791 [+], 495386865277type VI secretion system  TssB
9BP1026B_II1588 (tssC-5)2010815..2012314 [+], 1500386865278type VI secretion system  TssC
10BP1026B_II1591 (hcp-5)2012534..2013043 [+], 510386865279type VI secretion system  TssD
11BP1026B_II1592 (tssE-5)2013036..2013497 [+], 462386865280type VI secretion system  TssE
12BP1026B_II1594 (tssF-5)2013534..2015276 [+], 1743386865281type VI secretion system  TssF
13BP1026B_II1593 (tssG-5)2015264..2016286 [+], 1023386865282type VI secretion system  TssG
14BP1026B_II1595 (clpV-5)2016273..2019356 [+], 3084386865283type VI secretion system  TssH
15BP1026B_II1596 (vgrG-5)2019383..2022406 [+], 3024386865284type VI secretion system  TssI
16BP1026B_II1597 (tagAB-5)2022432..2025074 [+], 2643386865285type VI secretion system 
17BP1026B_II1598 (tagB-5)2025092..2026156 [+], 1065386865286type VI secretion system 
18BP1026B_II1599 (tagC-5)2026153..2026905 [+], 753386865287type VI secretion system 
19BP1026B_II1600 (tagD-5)2026934..2027326 [+], 393386865288type VI secretion system 
20BP1026B_II1602 (tssJ-5)2027525..2028133 [+], 609386865289type VI secretion system  TssJ
21BP1026B_II1601 (tssK-5)2028166..2029563 [+], 1398386865290type VI secretion system  TssK
22BP1026B_II1603 (tssL-5)2029560..2030225 [+], 666386865291type VI secretion system  TssL
23BP1026B_II1604 (tssM-5)2030240..2034286 [+], 4047386865292type VI secretion system  TssM
24BP1026B_II16052034995..2036218 [+], 1224386865293hypothetical protein  BMAA0729 (e)
25BP1026B_II16062036382..2036675 [+], 294386865294hypothetical protein 
26BP1026B_II16082036626..2037090 [-], 465386865295hypothetical protein 
27BP1026B_II16072036680..2037312 [+], 633386865296GTP cyclohydrolase I 
28BP1026B_II16092037746..2037901 [+], 156386865297hypothetical protein 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

Download FASTA format files
Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

Homology Effector list
BMAA0742 , BMAA0737, BMAA0729

Effector identified
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1BP1026B_II1591(hcp-5)2012534..2013043 [+], 510386865279type VI secretion system BMAA0742
2BP1026B_II1596(vgrG-5)2019383..2022406 [+], 3024386865284type VI secretion system BMAA0737
3BP1026B_II16052034995..2036218 [+], 1224386865293hypothetical protein BMAA0729

Download FASTA format files
Proteins        Genes
(1) Toesca IJ et al. (2014). The Type VI Secretion System Spike Protein VgrG5 Mediates Membrane Fusion during Intercellular Spread by Pseudomallei Group Burkholderia Species. Infect Immun. 82(4):1436-44. [PudMed:24421040] experimental
experimental This literature contains experimental investigation