I. Summary

SecReT6 ID	663
Strain	Cronobacter sakazakii ES15
Replicon	chromosome [Browse all T6SS(s) in this replicon]
Accession	NC_017933
Location	3020873..3052897
Comment
Function	N/A
T6SS Type	Type i; subtype i3
Bioinformatics investigation has been performed on this T6SS.

II. T6SS components

Component	TssH	TssD	TssL	TssI	TssA	TssB	TssC	TssE	TssF
Number	1	1	1	1	1	1	1	1	1
Component	TssG	TssJ	TssK	TssM
Number	1	1	1	3

III. genome coordinates of the T6SS gene cluster
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Note
1	ES15_2802	3016212..3016925 [-], 714	389841802	N-acetyltransferase GCN5
2	ES15_2803	3017063..3018223 [+], 1161	389841803	carboxylate-amine ligase
3	ES15_2804	3018488..3020395 [+], 1908	389841804	methyl-accepting chemotaxis protein
4	ES15_2805	3020873..3021355 [-], 483	389841805	hypothetical protein	TssE
5	ES15_2806 (impE1)	3021365..3022162 [-], 798	389841806	ImpE family protein	TagJ
6	ES15_2807	3022180..3022968 [-], 789	389841807	hypothetical protein
7	ES15_2808	3022974..3023234 [-], 261	389841808	hypothetical protein	PAAR
8	ES15_2809	3023290..3025725 [-], 2436	389841809	hypothetical protein	TssI
9	ES15_2810	3025765..3026313 [-], 549	389841810	hypothetical protein
10	ES15_2811 (icmF)	3026434..3027783 [-], 1350	389841811	IcmF family protein	TssM
11	ES15_2812	3027813..3028472 [-], 660	389841812	hypothetical protein	TssM
12	ES15_2813 (imcF)	3028469..3030208 [-], 1740	389841813	ImcF family protein	TssM
13	ES15_2814 (impK1)	3030220..3031563 [-], 1344	389841814	OmpA/MotB family protein 1	TssL
14	ES15_2815 (impJ1)	3031563..3032909 [-], 1347	389841815	type VI secretion protein	TssK
15	ES15_2816 (vasD2)	3032896..3033303 [-], 408	389841816	type VI secretion lipoprotein, VC_A0113 family 1	TssJ
16	ES15_2817 (hcp2)	3033608..3034093 [-], 486	389841817	type VI secretion system effector, Hcp1 family 2	TssD
17	ES15_2818 (impC2)	3034252..3035748 [-], 1497	389841818	type VI secretion protein EvpB	TssC
18	ES15_2819	3035771..3036301 [-], 531	389841819	type VI secretion protein	TssB
19	ES15_2820	3036391..3036552 [-], 162	389841820	fimbrial protein, truncated
20	ES15_2821	3036583..3036714 [+], 132	389841821	fimbrial protein, truncated
21	ES15_2822 (fimD3)	3036972..3039572 [-], 2601	389841822	fimbrial biogenesis outer membrane usher protein
22	ES15_2823	3039660..3040130 [-], 471	389841823	Gram-negative pili assembly chaperone
23	ES15_2824 (fimA2)	3040505..3041035 [-], 531	389841824	frimbrial protein
24	ES15_2825 (clpB2)	3041099..3043792 [-], 2694	389841825	Clp ATPase chaperone protein ClpB	TssH
25	ES15_2826 (impG)	3044323..3046203 [+], 1881	389841826	type VI secretion protein	TssF
26	ES15_2827 (impH1)	3046203..3047231 [+], 1029	389841827	type VI secretion protein	TssG
27	ES15_2828 (impA1)	3047286..3048332 [+], 1047	389841828	ImpA family protein	TssA
28	ES15_2829	3048337..3049332 [+], 996	389841829	fimbrial protein
29	ES15_2830	3049344..3050681 [+], 1338	389841830	hypothetical protein
30	ES15_2831	3050675..3051274 [+], 600	389841831	hypothetical protein
31	ES15_2832 (ompA2)	3051338..3052897 [+], 1560	389841832	OmpA/MotB family protein 2	TagL
32	ES15_2833	3052890..3053375 [+], 486	389841833	hypothetical protein
33	ES15_2834	3053439..3054392 [-], 954	389841834	MarR family transcriptional regulator with acetyltransferase activity
34	ES15_2835 (ygaP)	3054459..3054995 [-], 537	389841835	Inner membrane protein YgaP
35	ES15_2836	3054997..3055302 [-], 306	389841836	ArsR family transcriptional regulator
36	ES15_2837	3055508..3056701 [+], 1194	389841837	major facilitator superfamily protein
37	ES15_2838	3056811..3057164 [+], 354	389841838	hypothetical protein
38	ES15_2839	3057169..3057648 [-], 480	389841839	RES domain-containing protein

 Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.

1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

Homology Effector list

Hcp

Effector identified
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Homolog
1	ES15_2817(hcp2)	3033608..3034093 [-], 486	389841817	type VI secretion system effector, Hcp1 family 2	Hcp

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Proteins        Genes

N/A

N/A