I. Summary
SecReT6 ID68 insolico
StrainBurkholderia mallei ATCC 23344
Repliconchromosome II [Browse all T6SS(s) in this replicon]
T6SS TypeType i; subtype i3
insolico Bioinformatics investigation has been performed on this T6SS.

II. T6SS components
III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1BMA_RS17920371884..372825 [-], 942490295498LysR family transcriptional regulator 
2BMA_RS17925372922..374237 [+], 1316pseudogeneD-serine ammonia-lyase 
3BMA_RS17930374408..375322 [-], 915490294974LysR family transcriptional regulator 
4BMA_RS17935375504..376208 [+], 705490295326SDR family oxidoreductase 
5BMA_RS26115376770..376946 [-], 177490295390hypothetical protein 
6BMA_RS17940376995..377312 [-], 318490310751chorismate lyase 
7BMA_RS17945377249..377494 [-], 2461121458858chorismate lyase 
8BMA_RS17950377622..378857 [-], 1236741014115flavin-dependent oxidoreductase 
9BMA_RS17955379131..379316 [-], 186490295378hypothetical protein 
10BMA_RS17960379335..381233 [+], 1899490308269DUF3857 and transglutaminase domain-containing protein 
11BMA_RS17965 (tagH)381276..382712 [-], 1437490294955type VI secretion system-associated FHA domain protein TagH 
12BMA_RS17970382767..383168 [-], 402490294824TssQ family T6SS-associated lipoprotein 
13BMA_RS17975 (tssJ)383808..384326 [+], 519490295246type VI secretion system lipoprotein TssJ 
14BMA_RS17980 (tssK)384323..385726 [+], 1404490295036type VI secretion system baseplate subunit TssK 
15BMA_RS17985385742..387058 [+], 1317490295223DotU family type VI secretion system protein 
16BMA_RS17990 (tssM)387061..390690 [+], 3630490295215type VI secretion system membrane subunit TssM 
17BMA_RS17995 (tagF)390687..391602 [+], 916pseudogenetype VI secretion system-associated protein TagF 
18BMA_RS18000391587..391814 [-], 228490294720hypothetical protein 
19BMA_RS18005391813..394410 [+], 2598490295332protein kinase 
20BMA_RS18010 (tssA)394463..395542 [+], 1080490295524type VI secretion system protein TssA 
21BMA_RS18015 (tssB)395605..396183 [+], 579490295193type VI secretion system contractile sheath small subunit 
22BMA_RS18020 (tssC)396176..397684 [+], 1509490295385type VI secretion system contractile sheath large subunit 
23BMA_RS18025397744..398235 [+], 492490295232type VI secretion system tube protein Hcp 
24BMA_RS18030 (tssE)398254..398814 [+], 561490300750type VI secretion system baseplate subunit TssE 
25BMA_RS18035 (tssF)398819..400690 [+], 1872490294960type VI secretion system baseplate subunit TssF 
26BMA_RS18040 (tssG)400687..402177 [+], 1491490300751type VI secretion system baseplate subunit TssG 
27BMA_RS18045 (tssH)402156..404810 [+], 2655490295248type VI secretion system ATPase TssH 
28BMA_RS18050 (tssI)404807..407011 [+], 2205490308264type VI secretion system tip protein VgrG 
29BMA_RS18055407086..407739 [+], 654490300753hypothetical protein 
30BMA_RS18060407669..408727 [+], 1059490300756RHS repeat protein 
31BMA_RS18065408755..409875 [-], 1121741020948IS3 family transposase 
32BMA_RS18070409943..410536 [-], 594pseudogeneacyltransferase family protein 
33BMA_RS18075410549..411529 [-], 981499517700methyltransferase domain-containing protein 
34BMA_RS18080412046..413470 [+], 1425490295311cytosine permease 
35BMA_RS18085413467..414405 [+], 939490294691NAD-dependent protein deacetylase 
36BMA_RS18090414368..415045 [+], 678490294911DUF938 domain-containing protein 
37BMA_RS18095415369..415512 [-], 144490295039hypothetical protein 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

(1) Schell MA et al. (2007). Type VI secretion is a major virulence determinant in Burkholderia mallei. Mol Microbiol. 64(6):1466-85. [PudMed:17555434] experimental
experimental This literature contains experimental investigation