I. Summary

SecReT6 ID	68
Strain	Burkholderia mallei ATCC 23344
Replicon	chromosome II [Browse all T6SS(s) in this replicon]
Accession	NC_006349
Location	376517..411529
Comment
Function	N/A
T6SS Type	Type i; subtype i3
Bioinformatics investigation has been performed on this T6SS.

II. T6SS components

Component	TssH	TssD	TssL	TssI	TssA	TssB	TssC	TssE	TssF
Number	1	1	1	1	1	1	1	1	1
Component	TssG	TssJ	TssK	TssM
Number	1	1	1	1

III. genome coordinates of the T6SS gene cluster
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Note
1	BMAA0385	371884..372831 [-], 948	53716359	LysR family transcriptional regulator
2	BMAA0387	374408..375322 [-], 915	77358734	LysR family transcriptional regulator
3	BMAA0388	375504..376208 [+], 705	53716358	short chain dehydrogenase/reductase family oxidoreductase
4	BMAA0389	376517..377059 [+], 543	53716357	hypothetical protein
5	BMAA0390	376995..377312 [-], 318	77358733	hypothetical protein
6	BMAA0391	377622..378944 [-], 1323	53716356	hypothetical protein
7	BMAA0392	379335..381233 [+], 1899	53716355	hypothetical protein
8	BMAA0393	381276..382712 [-], 1437	53716354	FHA domain-containing protein	Fha
9	BMAA0394	382767..383168 [-], 402	53716353	lipoprotein
10	BMAA0395	383354..383638 [+], 285	53716352	hypothetical protein
11	BMAA0396	383787..384326 [+], 540	53716351	lipoprotein	TssJ
12	BMAA0397	384323..385726 [+], 1404	53716350	hypothetical protein	TssK
13	BMAA0398	385742..387058 [+], 1317	53716349	hypothetical protein	TssL
14	BMAA0399	387061..390690 [+], 3630	53716348	lipoprotein	TssM
15	BMAA0400	390672..391211 [+], 540	77358730	hypothetical protein
16	BMAA0400.1	391813..394410 [+], 2598	53717631	serine/threonine protein kinase
17	BMAA0402	394463..395542 [+], 1080	53716343	hypothetical protein	TssA
18	BMAA0403	395605..396183 [+], 579	77358729	hypothetical protein	TssB
19	BMAA0404	396176..397684 [+], 1509	77358942	hypothetical protein	TssC
20	BMAA0405	397744..398235 [+], 492	77358941	hypothetical protein	TssD
21	BMAA0406	398266..398814 [+], 549	77358940	hypothetical protein	TssE
22	BMAA0407	398819..400690 [+], 1872	77358939	hypothetical protein	TssF
23	BMAA0408	400807..402177 [+], 1371	77358937	hypothetical protein	TssG
24	BMAA0409	402156..404810 [+], 2655	53716607	ATP-dependent Clp protease, ATP-binding subunit ClpB	TssH
25	BMAA0410	404807..407011 [+], 2205	53716606	Rhs element Vgr protein	TssI
26	BMAA0412	407699..408727 [+], 1029	53716605	hypothetical protein
27	BMAA0413	408755..409588 [-], 834	53716604	IS407A, transposase OrfB
28	BMAA0414	409612..409875 [-], 264	53717424	IS407A, transposase OrfA
29	BMAA0415	409775..410476 [-], 702	77358731	hypothetical protein
30	BMAA0416	410549..411529 [-], 981	53716603	hypothetical protein
31	BMAA0417	412046..413470 [+], 1425	53716601	cytosine/purines/uracil/thiamine/allantoin permease family protein
32	BMAA0418	413467..414405 [+], 939	53716602	NAD-dependent deacetylase
33	BMAA0419	414431..415045 [+], 615	53716585	hypothetical protein

 Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.

1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

N/A

N/A

(1) Schell MA et al. (2007). Type VI secretion is a major virulence determinant in Burkholderia mallei. Mol Microbiol. 64(6):1466-85. [PudMed:17555434]

This literature contains experimental investigation