SecReT6
I. Summary
SecReT6 ID69 insolico
StrainBurkholderia mallei ATCC 23344
Repliconchromosome II [Browse all T6SS(s) in this replicon]
AccessionNC_006349
Location429068..465354
Comment
FunctionN/A
T6SS TypeType i; subtype i3
insolico Bioinformatics investigation has been performed on this T6SS.

II. T6SS components
ComponentTssHTssDTssLTssITssATssBTssCTssETssF
Number011201111
ComponentTssGTssJTssKTssM
Number1101
III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1BMA_RS18145425119..426153 [+], 1035490294883lipase secretion chaperone 
2BMA_RS18150426255..427784 [-], 1530490305476PLP-dependent aminotransferase family protein 
3BMA_RS18155427893..428993 [+], 1101490295292ABC transporter ATP-binding protein 
4BMA_RS18160429068..430114 [+], 1047490295316ABC transporter substrate-binding protein 
5BMA_RS18165430215..431474 [+], 1260490300774ABC transporter permease 
6BMA_RS18170431505..432331 [+], 827pseudogeneABC transporter permease 
7BMA_RS18175432426..432857 [-], 432pseudogenepeptidase S53 
8BMA_RS18180432906..434026 [-], 1121741020948IS3 family transposase 
9BMA_RS18185 (tssB)434096..434563 [+], 468pseudogenetype VI secretion system contractile sheath small subunit 
10BMA_RS18190 (tssC)434566..436071 [+], 1506490295382type VI secretion system contractile sheath large subunit 
11BMA_RS18195436215..436742 [+], 528490300780type VI secretion system tube protein Hcp 
12BMA_RS18200436822..437253 [+], 432490295415GPW/gp25 family protein 
13BMA_RS18205 (tssF)437267..439129 [+], 1863490300782type VI secretion system baseplate subunit TssF 
14BMA_RS18210 (tssG)439126..440115 [+], 990490295387type VI secretion system baseplate subunit TssG 
15BMA_RS18215 (tssH)440118..442988 [+], 2871pseudogenetype VI secretion system ATPase TssH 
16BMA_RS18220 (vgrG)442979..445225 [+], 2247490300787type VI secretion system tip protein VgrG 
17BMA_RS18225 (vgrG)445391..447679 [+], 2289490295014type VI secretion system tip protein VgrG 
18BMA_RS18230447683..449899 [+], 2217490305479pentapeptide repeat-containing protein 
19BMA_RS18235449899..450969 [+], 1071490307160pentapeptide repeat-containing protein 
20BMA_RS18240450972..451688 [+], 717490387208DUF3540 domain-containing protein 
21BMA_RS18245451731..452120 [+], 390490295064DUF4150 domain-containing protein 
22BMA_RS18250 (tssK)452305..453450 [+], 1146490300801type VI secretion system baseplate subunit TssK 
23BMA_RS18255453469..454077 [+], 609490311553type VI secretion system baseplate subunit TssK 
24BMA_RS18260454160..455818 [+], 1659490294913type IVB secretion system protein IcmH/DotU 
25BMA_RS18265 (tssM)455815..459318 [+], 3504490294712type VI secretion system membrane subunit TssM 
26BMA_RS18270459377..459736 [+], 360490295399hypothetical protein 
27BMA_RS18275459759..460184 [+], 426490294922hypothetical protein 
28BMA_RS18280460505..460780 [+], 276490295280hypothetical protein 
29BMA_RS18285461331..462230 [+], 900490291378alpha/beta hydrolase 
30BMA_RS18290462272..462562 [-], 291490305952hypothetical protein 
31BMA_RS18295462452..463771 [+], 1320490291357glycosyltransferase 
32BMA_RS18300463768..465354 [+], 1587490288762DHA2 family efflux MFS transporter permease subunit 
33BMA_RS18305465619..466614 [+], 996490291223glycosyltransferase family 2 protein 
34BMA_RS18315466919..468514 [+], 1596490300954efflux transporter outer membrane subunit 
35BMA_RS18320468995..470248 [+], 1254490291248efflux RND transporter periplasmic adaptor subunit 
 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

Download FASTA format files
Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.
 






2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.
 






3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.
 







Homology Effector list
YPK_3563

Effector identified
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog

Download FASTA format files
Proteins        Genes
N/A
(1) Schell MA et al. (2007). Type VI secretion is a major virulence determinant in Burkholderia mallei. Mol Microbiol. 64(6):1466-85. [PudMed:17555434] experimental
 
experimental This literature contains experimental investigation