I. Summary
SecReT6 ID69 insolico
StrainBurkholderia mallei ATCC 23344
Repliconchromosome II [Browse all T6SS(s) in this replicon]
T6SS TypeType i; subtype i3
insolico Bioinformatics investigation has been performed on this T6SS.

II. T6SS components
III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1BMAA0429425119..426153 [+], 103553716568lipase chaperone 
2BMAA0430426255..427775 [-], 152153716567GntR family transcriptional regulator 
3BMAA0431427893..428993 [+], 110153716566spermidine/putrescine ABC transporter, ATP-binding protein 
4BMAA0432429068..430114 [+], 104753716565spermidine/putrescine ABC transporter, periplasmic spermidine/putrescine-binding protein 
5BMAA0433430215..431474 [+], 126053716564spermidine/putrescine ABC transporter, permease protein 
6BMAA0435432426..432884 [-], 45977358925serine protease 
7BMAA0436432906..433739 [-], 83453716557IS407A, transposase OrfB 
8BMAA0437433763..434026 [-], 26453717423IS407A, transposase OrfA 
9BMAA0438434138..434563 [+], 42677358923hypothetical protein  TssB
10BMAA0439434560..436071 [+], 151253716556hypothetical protein  TssC
11BMAA0440436215..436742 [+], 52877358921hypothetical protein  TssD
12BMAA0441436822..437253 [+], 43277358919hypothetical protein  TssE
13BMAA0442437267..439129 [+], 186377358918hypothetical protein  TssF
14BMAA0443439126..440115 [+], 99077358917hypothetical protein  TssG
15BMAA0445442979..445225 [+], 224753716549Rhs element Vgr protein  TssI
16BMAA0446445391..447679 [+], 228977358915Rhs element Vgr protein  TssI
17BMAA0447448268..449899 [+], 163253716548hypothetical protein 
18BMAA0448449899..450969 [+], 107153716547pentapeptide repeat-containing protein 
19BMAA0449450972..451688 [+], 71753716546hypothetical protein 
20BMAA0450451731..452120 [+], 39077358914hypothetical protein 
21BMAA0451452126..452719 [+], 59453716545lipoprotein  TssJ
22BMAA0453454103..455818 [+], 171653716506hypothetical protein  TssL
23BMAA0454455875..459318 [+], 344453716505hypothetical protein  TssM
24BMAA0455459377..459736 [+], 36077358798hypothetical protein 
25BMAA0456459824..460327 [+], 50453716504hypothetical protein 
26BMAA0457460387..460548 [+], 16277358794hypothetical protein 
27BMAA0458460878..461051 [-], 17477358793hypothetical protein 
28BMAA0459 (rhlA-1)461331..462230 [+], 90053716496rhamnosyltransferase I, subunit A 
29BMAA0460 (rhlB-1)462452..463771 [+], 132053717492rhamnosyltransferase I, subunit B 
30BMAA0461463768..465354 [+], 158753717491multidrug resistance protein 
31BMAA0462 (rhlC)465619..466614 [+], 99653717489rhamnosyltransferase II 
32BMAA0463466919..468514 [+], 159653717488RND efflux system outer membrane lipoprotein 
33BMAA0464469082..470248 [+], 116753717493multidrug resistance protein 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

Homology Effector list

Effector identified
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1BMAA0440436215..436742 [+], 52877358921hypothetical protein YPK_3563

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Proteins        Genes
(1) Schell MA et al. (2007). Type VI secretion is a major virulence determinant in Burkholderia mallei. Mol Microbiol. 64(6):1466-85. [PudMed:17555434] experimental
experimental This literature contains experimental investigation