I. Summary

SecReT6 ID	700
Strain	Escherichia coli O104:H4 str. 2009EL-2050
Replicon	chromosome [Browse all T6SS(s) in this replicon]
Accession	NC_018650
Location	4146167..4187697
Comment
Function	N/A
T6SS Type	Type i; subtype i1
Bioinformatics investigation has been performed on this T6SS.

II. T6SS components

Component	TssH	TssD	TssL	TssI	TssA	TssB	TssC	TssE	TssF
Number	1	2	1	1	1	1	2	1	1
Component	TssG	TssJ	TssK	TssM
Number	1	1	1	1

III. genome coordinates of the T6SS gene cluster
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Note
1	O3M_20185 (prfH)	4142596..4143210 [-], 615	410484114	peptide chain release factor-like protein
2	O3M_20190	4143207..4144346 [-], 1140	410484115	hypothetical protein
3	O3M_20195	4144592..4145044 [-], 453	410484116	acyltransferase
4	O3M_20200	4145041..4146096 [-], 1056	410484117	DNA polymerase IV
5	O3M_20205	4146167..4146952 [-], 786	410484118	hypothetical protein	TagL
6	O3M_20210	4146897..4148636 [+], 1740	410484119	flagellar system protein
7	O3M_20215	4148741..4149019 [+], 279	410484120	hypothetical protein
8	O3M_20220	4149012..4149368 [+], 357	410484121	HicB protein
9	O3M_20225	4149425..4150174 [-], 750	410484122	hydrolase
10	O3M_20230	4150384..4150644 [+], 261	410484123	DNA-damage-inducible protein J
11	O3M_20235	4150647..4150925 [+], 279	410484124	toxin of the YafQ-DinJ toxin-antitoxin system
12	O3M_20240	4151081..4151821 [+], 741	410484125	hypothetical protein
13	O3M_20245	4151792..4152559 [-], 768	410484126	amidotransferase
14	O3M_20250 (gmhA)	4152765..4153343 [-], 579	410484127	phosphoheptose isomerase
15	O3M_20255 (fadE)	4153583..4156027 [+], 2445	410484128	acyl-CoA dehydrogenase
16	O3M_20260	4156070..4156543 [-], 474	410484129	C-lysozyme inhibitor
17	O3M_20265	4156697..4157467 [+], 771	410484130	C-N hydrolase family amidase
18	O3M_20270	4157509..4158570 [-], 1062	410484131	transposase
19	O3M_20285	4160055..4160537 [-], 483	410484132	hypothetical protein
20	O3M_20290	4160521..4161711 [-], 1191	410484133	Rhs Core protein
21	O3M_20295	4161680..4164184 [-], 2505	410484134	Rhs core protein	PAAR
22	O3M_20300	4164260..4166401 [-], 2142	410484135	hypothetical protein	TssI
23	O3M_20305	4166611..4167129 [-], 519	410484136	hypothetical protein	TssD
24	O3M_20310	4167256..4167399 [-], 144	410484137	hypothetical protein
25	O3M_20315	4167826..4168326 [+], 501	410484138	hypothetical protein	TssB
26	O3M_20320	4168361..4168585 [+], 225	410484139	hypothetical protein	TssC
27	O3M_20325	4168636..4170111 [+], 1476	410484140	hypothetical protein	TssC
28	O3M_20330	4170118..4170531 [+], 414	410484141	hypothetical protein	TssE
29	O3M_20335	4170535..4172385 [+], 1851	410484142	type VI secretion system protein ImpG	TssF
30	O3M_20340	4172349..4173431 [+], 1083	410484143	hypothetical protein	TssG
31	O3M_20345	4173456..4174736 [+], 1281	410484144	type VI secretion system protein ImpI	Fha
32	O3M_20350	4174733..4175257 [+], 525	410484145	lipoprotein	TssJ
33	O3M_20355	4175260..4176591 [+], 1332	410484146	hypothetical protein	TssK
34	O3M_20360	4176596..4177357 [+], 762	410484147	membrane protein Aec26	TssL
35	O3M_20365	4177366..4180125 [+], 2760	410484148	ATP-dependent Clp proteinase ATP-binding subunit	TssH
36	O3M_20370	4180122..4180865 [+], 744	410484149	hypothetical protein
37	O3M_20375	4180870..4182285 [+], 1416	410484150	hypothetical protein
38	O3M_20380	4182304..4185828 [+], 3525	410484151	IcmF-like protein	TssM
39	O3M_20385	4185839..4187191 [+], 1353	410484152	hypothetical protein	TssA
40	O3M_20390	4187215..4187697 [+], 483	410484153	hypothetical protein	TssD
41	O3M_20395	4187741..4188655 [+], 915	410484154	hypothetical protein
42	O3M_20400	4188665..4189144 [+], 480	410484155	hypothetical protein
43	O3M_20405	4189281..4190066 [-], 786	410484156	aminopeptidase
44	O3M_20410	4190602..4191333 [-], 732	410484157	DNA polymerase III subunit epsilon
45	O3M_20415 (rnhA)	4191398..4191865 [+], 468	410484158	ribonuclease H
46	O3M_20420	4191862..4192584 [-], 723	410484159	S-adenosyl-L-methionine-dependent methyltransferase

 Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.

1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

Homology Effector list

ABG57132

Effector identified
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Homolog
1	O3M_20305	4166611..4167129 [-], 519	410484136	hypothetical protein	ABG57132

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Proteins        Genes

N/A

N/A