I. Summary
SecReT6 ID71 insolico
StrainBurkholderia mallei ATCC 23344
Repliconchromosome II [Browse all T6SS(s) in this replicon]
T6SS TypeType i; subtype i3
insolico Bioinformatics investigation has been performed on this T6SS.

II. T6SS components
III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1BMA_RS249852071093..2071485 [-], 393490300834helix-turn-helix domain-containing protein 
2BMA_RS249902071559..2072335 [-], 777490292162NAD(P)H-dependent oxidoreductase 
3BMA_RS249952072431..2073324 [+], 894490292041LysR family transcriptional regulator 
4BMA_RS250002073664..2075580 [+], 1917490292232SMP-30/gluconolactonase/LRE family protein 
5BMA_RS250052076300..2076680 [-], 381490305535DUF4150 domain-containing protein 
6BMA_RS250102076721..2077380 [-], 660490292309DUF3540 domain-containing protein 
7BMA_RS250202077562..2078644 [-], 1083490300838pentapeptide repeat-containing protein 
8BMA_RS250252078641..2081118 [-], 2478490293000DUF2169 domain-containing protein 
9BMA_RS25030 (tssI)2081150..2083477 [-], 2328490292795type VI secretion system tip protein VgrG 
10BMA_RS250352083549..2084652 [-], 1104490300843type VI secretion system ImpA family N-terminal domain-containing protein 
11BMA_RS25040 (tssG)2084649..2085733 [-], 1085pseudogenetype VI secretion system baseplate subunit TssG 
12BMA_RS25045 (tssF)2085733..2087622 [-], 1890490292404type VI secretion system baseplate subunit TssF 
13BMA_RS25050 (tssE)2087653..2088234 [-], 582490291463type VI secretion system baseplate subunit TssE 
14BMA_RS250552088221..2089186 [-], 966490292338ImpE/SciE family protein 
15BMA_RS250602089183..2089929 [-], 747490292963TagK domain-containing protein 
16BMA_RS25065 (tssH)2090435..2093358 [+], 2924pseudogenetype VI secretion system ATPase TssH 
17BMA_RS25070 (tssB)2093394..2093975 [+], 582490300845type VI secretion system contractile sheath small subunit 
18BMA_RS25075 (tssC)2094010..2095509 [+], 1500490292430type VI secretion system contractile sheath large subunit 
19BMA_RS250802095626..2096111 [+], 486490292729type VI secretion system tube protein Hcp 
20BMA_RS25085 (tssJ)2096218..2096721 [+], 504490291678type VI secretion system lipoprotein TssJ 
21BMA_RS25090 (tssK)2096743..2098089 [+], 1347490293169type VI secretion system baseplate subunit TssK 
22BMA_RS25095 (tssL)2098178..2099443 [+], 1266490292954type VI secretion system protein TssL, long form 
23BMA_RS25100 (tssM)2099472..2103547 [+], 4076pseudogenetype VI secretion system membrane subunit TssM 
24BMA_RS251052103567..2103797 [+], 231490292709hypothetical protein 
25BMA_RS251102104383..2105729 [+], 1347490300848LysR family transcriptional regulator 
26BMA_RS251152105972..2106898 [-], 927490291401catecholic dioxygenase 
27BMA_RS251202106953..2107924 [-], 972490291908quinone oxidoreductase 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

(1) Schell MA et al. (2007). Type VI secretion is a major virulence determinant in Burkholderia mallei. Mol Microbiol. 64(6):1466-85. [PudMed:17555434] experimental
experimental This literature contains experimental investigation