I. Summary

SecReT6 ID	719
Strain	Vibrio parahaemolyticus BB22OP
Replicon	chromosome I [Browse all T6SS(s) in this replicon]
Accession	NC_019955
Location	1464178..1493343
Comment
Function	N/A
T6SS Type	Type i; subtype i1
Bioinformatics investigation has been performed on this T6SS.

II. T6SS components

Component	TssH	TssD	TssL	TssI	TssA	TssB	TssC	TssE	TssF
Number	1	1	1	1	2	1	1	1	1
Component	TssG	TssJ	TssK	TssM
Number	1	1	1	1

III. genome coordinates of the T6SS gene cluster
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Note
1	VPBB_1307	1462563..1464191 [-], 1629	433657589	Sigma-54 dependent transcriptional regulator, FhlA family
2	VPBB_1308	1464178..1466850 [-], 2673	433657590	ClpB protein	TssH
3	VPBB_1309	1467305..1467823 [+], 519	433657591	TypeVI secretion Hcp protein, biofilm development	TssD
4	VPBB_1310	1467896..1469974 [+], 2079	433657592	VgrG protein	TssI
5	VPBB_1311	1469974..1470459 [+], 486	433657593	hypothetical protein
6	VPBB_1312	1470537..1471856 [+], 1320	433657594	hypothetical protein
7	VPBB_1313	1471837..1472829 [+], 993	433657595	hypothetical protein
8	VPBB_1314	1472822..1473766 [+], 945	433657596	hypothetical protein
9	VPBB_1315	1474001..1476004 [+], 2004	433657597	hypothetical protein
10	VPBB_1316	1476004..1477578 [+], 1575	433657598	Uncharacterized protein ImpA	TssA
11	VPBB_1317	1477605..1478111 [+], 507	433657599	Uncharacterized protein ImpB	TssB
12	VPBB_1318	1478120..1479595 [+], 1476	433657600	Uncharacterized protein ImpC	TssC
13	VPBB_1319	1479657..1480067 [+], 411	433657601	hypothetical protein	TssE
14	VPBB_1320	1480078..1481826 [+], 1749	433657602	Protein ImpG	TssF
15	VPBB_1321	1481823..1482821 [+], 999	433657603	Uncharacterized protein ImpH	TssG
16	VPBB_1322	1482885..1483190 [-], 306	433657604	Transcriptional regulator, AsnC family
17	VPBB_1323	1483370..1486759 [-], 3390	433657605	IcmF-related protein	TssM
18	VPBB_1324	1486781..1488076 [-], 1296	433657606	Uncharacterized protein ImpA	TssA
19	VPBB_1325	1488692..1489195 [+], 504	433657607	hypothetical protein
20	VPBB_1326	1489205..1490725 [+], 1521	433657608	Uncharacterized protein ImpI	Fha
21	VPBB_1327	1490769..1491218 [+], 450	433657609	Type VI secretion lipoprotein	TssJ
22	VPBB_1328	1491230..1492555 [+], 1326	433657610	Uncharacterized protein ImpJ	TssK
23	VPBB_1329	1492552..1493343 [+], 792	433657611	Outer membrane protein ImpK	TssL
24	VPBB_1330	1493493..1495016 [+], 1524	433657612	hypothetical protein
25	VPBB_1331	1495016..1495897 [+], 882	433657613	hypothetical protein
26	VPBB_1332	1496373..1496507 [+], 135	433657614	hypothetical protein
27	VPBB_1333	1496510..1497001 [+], 492	433657615	hypothetical protein
28	VPBB_1334	1497186..1497479 [+], 294	433657616	hypothetical protein
29	VPBB_1335	1497497..1497616 [-], 120	433657617	hypothetical protein
30	VPBB_1336	1497639..1498241 [+], 603	433657618	SM-20-related protein

 Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.

1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

Homology Effector list

VP1393

Effector identified
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Homolog
1	VPBB_1309	1467305..1467823 [+], 519	433657591	TypeVI secretion Hcp protein, biofilm development	VP1393

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Proteins        Genes

N/A

Regulatory element identified

OpaR

Regulator	Description	Reference
OpaR (VPBB_2338)	Repressor	PMID: 21705592

(1) Gode-Potratz CJ et al. (2011). Quorum sensing and silencing in Vibrio parahaemolyticus. J Bacteriol. 193(16):4224-37. [PudMed:21705592]

This literature contains experimental investigation