I. Summary

SecReT6 ID	720
Strain	Vibrio parahaemolyticus BB22OP
Replicon	chromosome II [Browse all T6SS(s) in this replicon]
Accession	NC_019971
Location	1048650..1070709
Comment
Function	N/A
T6SS Type	Type i; subtype i5
Bioinformatics investigation has been performed on this T6SS.

II. T6SS components

Component	TssH	TssD	TssL	TssI	TssA	TssB	TssC	TssE	TssF
Number	1	1	1	1	1	1	2	1	1
Component	TssG	TssJ	TssK	TssM
Number	1	1	1	1

III. genome coordinates of the T6SS gene cluster
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Note
1	VPBB_A0930	1046273..1047406 [-], 1134	433660100	Exonuclease SbcD
2	VPBB_A0931	1047503..1048345 [-], 843	433660101	transhydrogenase beta subunit
3	VPBB_A0932	1048650..1050485 [-], 1836	433660102	VgrG protein	TssI
4	VPBB_A0933	1050543..1051022 [-], 480	433660103	Putative cytoplasmic protein USSDB7A	TssD
5	VPBB_A0934	1051228..1053795 [-], 2568	433660104	ClpA/B-type chaperone	TssH
6	VPBB_A0935	1053806..1054771 [-], 966	433660105	hypothetical protein	TssG
7	VPBB_A0936	1054768..1056591 [-], 1824	433660106	Protein ImpG/VasA	TssF
8	VPBB_A0937	1056588..1057052 [-], 465	433660107	Uncharacterized protein ImpF	TssE
9	VPBB_A0938	1057061..1057858 [-], 798	433660108	Protein of avirulence locus ImpE	TagJ
10	VPBB_A0939	1057869..1059380 [-], 1512	433660109	Uncharacterized protein ImpD	TssC
11	VPBB_A0940	1059436..1060929 [-], 1494	433660110	Uncharacterized protein ImpC	TssC
12	VPBB_A0941	1060929..1061375 [-], 447	433660111	Uncharacterized protein ImpB	TssB
13	VPBB_A0942	1061475..1062596 [-], 1122	433660112	Uncharacterized protein ImpA	TssA
14	VPBB_A0943	1062593..1063381 [-], 789	433660113	putative phosphoprotein phosphatase
15	VPBB_A0944	1063392..1064087 [-], 696	433660114	Protein phosphatase ImpM
16	VPBB_A0945	1064069..1067599 [-], 3531	433660115	IcmF-related protein	TssM
17	VPBB_A0946	1067603..1068895 [-], 1293	433660116	Type VI secretion system family protein	TssL
18	VPBB_A0947	1068907..1070196 [-], 1290	433660117	hypothetical protein	TssK
19	VPBB_A0948	1070254..1070709 [-], 456	433660118	Type VI secretion protein	TssJ
20	VPBB_A0949	1070719..1071915 [-], 1197	433660119	hypothetical protein	Fha
21	VPBB_A0950	1072238..1074385 [+], 2148	433660120	protein kinase

 Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.

1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

Homology Effector list

VPA1027

Effector identified
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Homolog
1	VPBB_A0933	1050543..1051022 [-], 480	433660103	Putative cytoplasmic protein USSDB7A	VPA1027

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Proteins        Genes

N/A

Regulatory element identified

OpaR

Regulator	Description	Reference
OpaR (VPBB_2338)	Activator	PMID: 21705592

(1) Gode-Potratz CJ et al. (2011). Quorum sensing and silencing in Vibrio parahaemolyticus. J Bacteriol. 193(16):4224-37. [PudMed:21705592]

This literature contains experimental investigation