SecReT6
I. Summary
SecReT6 ID74 insolico
StrainBurkholderia pseudomallei K96243
Repliconchromosome II [Browse all T6SS(s) in this replicon]
AccessionNC_006351
Location702116..728854
Comment
FunctionN/A
T6SS TypeType i; subtype i3
insolico Bioinformatics investigation has been performed on this T6SS.

II. T6SS components
ComponentTssHTssDTssLTssITssATssBTssCTssETssF
Number111211111
ComponentTssGTssJTssKTssM
Number1111
III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1BPS_RS21480697828..698517 [-], 690490292693CDP-alcohol phosphatidyltransferase family protein 
2BPS_RS21485698882..700396 [+], 1515490292843acetyl-CoA hydrolase/transferase family protein 
3BPS_RS21490702116..703054 [+], 939490660555type VI secretion system ImpA family N-terminal domain-containing protein 
4BPS_RS21495 (tssB)703088..703636 [+], 549490307165type VI secretion system contractile sheath small subunit 
5BPS_RS21500 (tssC)703639..705144 [+], 1506490295382type VI secretion system contractile sheath large subunit 
6BPS_RS21505705288..705815 [+], 528490665049type VI secretion system tube protein Hcp 
7BPS_RS21510705895..706326 [+], 432490295415GPW/gp25 family protein 
8BPS_RS21515 (tssF)706340..708202 [+], 1863490300782type VI secretion system baseplate subunit TssF 
9BPS_RS21520 (tssG)708199..709188 [+], 990490295387type VI secretion system baseplate subunit TssG 
10BPS_RS21525 (tssH)709191..712061 [+], 2871490660557type VI secretion system ATPase TssH 
11BPS_RS21530 (vgrG)712052..714343 [+], 2292490670254type VI secretion system tip protein VgrG 
12BPS_RS21535 (vgrG)714509..716797 [+], 2289490295014type VI secretion system tip protein VgrG 
13BPS_RS21540716801..719017 [+], 2217490665051pentapeptide repeat-containing protein 
14BPS_RS21545719017..720087 [+], 1071490660560pentapeptide repeat-containing protein 
15BPS_RS21550720090..720806 [+], 717490660561DUF3540 domain-containing protein 
16BPS_RS21555720849..721238 [+], 390490295064DUF4150 domain-containing protein 
17BPS_RS21560721244..721837 [+], 594490665052type VI secretion lipoprotein TssJ 
18BPS_RS21565 (tssK)721834..723195 [+], 1362490660562type VI secretion system baseplate subunit TssK 
19BPS_RS21570723278..724936 [+], 1659490660563type IVB secretion system protein IcmH/DotU 
20BPS_RS21575 (tssM)724933..728436 [+], 3504490294712type VI secretion system membrane subunit TssM 
21BPS_RS21580728495..728854 [+], 360490295399hypothetical protein 
22BPS_RS21585728877..729302 [+], 426490294922hypothetical protein 
23BPS_RS21590729623..729898 [+], 276490671823hypothetical protein 
24BPS_RS21595730449..731348 [+], 900490663671alpha/beta hydrolase 
25BPS_RS21600731390..731680 [-], 291490665522hypothetical protein 
26BPS_RS21605731570..732889 [+], 1320499518784glycosyltransferase 
 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.
 






2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.
 






3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.
 







Homology Effector list
YPK_3563

Effector identified
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog

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Proteins        Genes
N/A
The information on regulator interaction.

#homolog effector locus tagRegulator wayFunctionRegulate targetDescription
1BPSL3431 (TctR)Transcription regulator-T6SS-2 (hcp2) transcript TctR negatively regulates expression of the T6SS-2 gene cluster.
2BPSL3431 (TctR)Transcription regulator+T6SS-6 (hcp6) transcriptTctR positively regulates expression of the T6SS-6 gene cluster.
(1) Burtnick MN et al. (2011). The cluster 1 type VI secretion system is a major virulence determinant in Burkholderia pseudomallei. Infect Immun. 79(4):1512-25. [PudMed:21300775] experimental
 
experimental This literature contains experimental investigation