I. Summary
SecReT6 ID74 insolico
StrainBurkholderia pseudomallei K96243
Repliconchromosome II [Browse all T6SS(s) in this replicon]
T6SS TypeType i; subtype i3
insolico Bioinformatics investigation has been performed on this T6SS.

II. T6SS components
III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1BPSS0513697828..698517 [-], 69053721549CDP-alcohol phosphatidyltransferase 
2BPSS0514698792..700396 [+], 160553721550acetyl-CoA hydrolase/transferase 
3BPSS0515702116..703054 [+], 93953721551hypothetical protein  TssA
4BPSS0516703088..703636 [+], 54953721552hypothetical protein  TssB
5BPSS0517703633..705144 [+], 151253721553hypothetical protein  TssC
6BPSS0518705288..705815 [+], 52853721554hypothetical protein  TssD
7BPSS0519705856..706326 [+], 47153721555hypothetical protein  TssE
8BPSS0520706340..708202 [+], 186353721556hypothetical protein  TssF
9BPSS0521708199..709188 [+], 99053721557hypothetical protein  TssG
10BPSS0522709191..712061 [+], 287153721558ATPase  TssH
11BPSS0523712052..714343 [+], 229253721559hypothetical protein  TssI
12BPSS0524714509..716797 [+], 228953721560hypothetical protein  TssI
13BPSS0525716801..719017 [+], 221753721561hypothetical protein 
14BPSS0526719014..720087 [+], 107453721562hypothetical protein 
15BPSS0527720090..720806 [+], 71753721563hypothetical protein 
16BPSS0528720849..721238 [+], 39053721564hypothetical protein 
17BPSS0529721244..721837 [+], 59453721565lipoprotein  TssJ
18BPSS0530721834..723195 [+], 136253721566hypothetical protein  TssK
19BPSS0531723278..724936 [+], 165953721567hypothetical protein  TssL
20BPSS0532724933..728436 [+], 350453721568hypothetical protein  TssM
21BPSS0533728495..728854 [+], 36053721569hypothetical protein 
22BPSS0534728877..729302 [+], 42653721570hypothetical protein 
23BPSS0535729527..729898 [+], 37253721571hypothetical protein 
24BPSS0536730449..731348 [+], 900537215723-hydroxydecanoyl-ACP:CoA transacylase 
25BPSS0537731570..732889 [+], 132053721573UDP-glucoronosyl and UDP-glucosyl transferase 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

Homology Effector list

Effector identified
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1BPSS0518705288..705815 [+], 52853721554hypothetical protein YPK_3563

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Proteins        Genes
The information on regulator interaction.

#homolog effector locus tagRegulator wayFunctionRegulate targetDescription
1BPSL3431 (TctR)Transcription regulator-T6SS-2 (hcp2) transcript TctR negatively regulates expression of the T6SS-2 gene cluster.
2BPSL3431 (TctR)Transcription regulator+T6SS-6 (hcp6) transcriptTctR positively regulates expression of the T6SS-6 gene cluster.
(1) Burtnick MN et al. (2011). The cluster 1 type VI secretion system is a major virulence determinant in Burkholderia pseudomallei. Infect Immun. 79(4):1512-25. [PudMed:21300775] experimental
experimental This literature contains experimental investigation