SecReT6
I. Summary
SecReT6 ID757 insolico
StrainSalmonella enterica subsp. enterica serovar Typhimurium str. U288
Repliconchromosome [Browse all T6SS(s) in this replicon]
AccessionNC_021151
Location2757038..2802607
Comment
FunctionN/A
T6SS TypeType i; subtype i3
insolico Bioinformatics investigation has been performed on this T6SS.

II. T6SS components
ComponentTssHTssDTssLTssITssATssBTssCTssETssF
Number221111111
ComponentTssGTssJTssKTssM
Number1111
III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1STU288_132852752198..2752461 [-], 264482905190hypothetical protein 
2STU288_132902752455..2756549 [-], 4095482905191putative RHS-like protein  PAAR
3STU288_132952756568..2757014 [-], 447482905192hypothetical protein 
4STU288_133002757038..2759227 [-], 2190482905193putative cytoplasmic protein  TssI
5STU288_133052759624..2760142 [-], 519482905194SPI-6 associated protein 
6STU288_133102760169..2760585 [-], 417482905195hypothetical protein 
7STU288_133152760582..2761370 [-], 789482905196putative cytoplasmic protein 
8STU288_133202761370..2765239 [-], 3870482905197putative inner membrane protein  TssM
9STU288_133252765273..2765629 [-], 357482905198putative shiga-like toxin A subunit 
10STU288_133302765907..2766680 [-], 774482905199membrane protein, virulence associated protein 
11STU288_133352766685..2767989 [-], 1305482905200hypothetical protein  TssL
12STU288_133402767986..2769329 [-], 1344482905201type VI secretion protein  TssK
13STU288_133452769333..2769869 [-], 537482905202putative outer membrane lipoprotein  TssJ
14STU288_133502769936..2770421 [-], 486482905203Protein hcp1  TssD
15STU288_133552770564..2770935 [-], 372482905204putative periplasmic protein  STM0278 (i)
16STU288_133602770932..2771417 [-], 486482905205putative cytoplasmic protein  STM0277 (e)
17STU288_133652771547..2771654 [-], 108482905206lipoprotein 
18STU288_133702771722..2772207 [-], 486482905207Protein hcp1  TssD
19STU288_133752773093..2774601 [-], 1509482905208SciI protein  TssC
20STU288_133802774625..2775167 [-], 543482905209SPI-6 associated protein  TssB
21STU288_133852775267..2777906 [-], 2640482905210SPI-6 associated protein  TssH
22STU288_133902778274..2779176 [+], 903482905211SPI-6 associated protein 
23STU288_133952779163..2779987 [+], 825482905212SciE protein  TagJ
24STU288_134002779984..2780478 [+], 495482905213hypothetical protein  TssE
25STU288_134052780494..2782377 [+], 1884482905214hypothetical protein  TssF
26STU288_134102782374..2783369 [+], 996482905215SPI-6 associated protein  TssG
27STU288_134152783380..2784435 [+], 1056482905216putative cytoplasmic protein  TssA
28STU288_134202784526..2784633 [-], 108482905217hypothetical protein 
29STU288_134252784967..2785698 [-], 732482905218DNA polymerase III subunit epsilon 
30STU288_13430 (rnhA)2785762..2786229 [+], 468482905219ribonuclease H 
31STU288_134352786226..2786948 [-], 723482905220hypothetical protein 
32STU288_134402786983..2787738 [+], 756482905221hydroxyacylglutathione hydrolase 
33STU288_13445 (mltD)2787810..2789177 [+], 1368482905222membrane-bound lytic murein transglycosylase D 
34STU288_134502789233..2790003 [-], 771482905223putative methyltransferase 
35STU288_134552790081..2790881 [-], 801482905224hypothetical protein 
36STU288_134602791013..2792188 [-], 1176482905225inner membrane transport protein YdhP 
37STU288_134652792293..2793207 [+], 915482905226LysR family transcriptional regulator 
38STU288_13470 (dkgB)2793228..2794031 [-], 8044829052272,5-diketo-D-gluconate reductase B 
39STU288_134752800034..2802607 [-], 2574482905228protein disaggregation chaperone  TssH
40STU288_134802802737..2803468 [-], 732482905229hypothetical protein 
41STU288_13485 (rluD)2803465..2804445 [-], 98148290523023S rRNA pseudouridine synthase D 
42STU288_134902804577..2805314 [+], 738482905231outer membrane biogenesis protein BamD 
43STU288_134952805586..2805924 [+], 339482905232translation inhibitor protein RaiA 
44STU288_13500 (pheA)2806175..2807335 [+], 1161482905233bifunctional chorismate mutase/prephenate dehydratase 
 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.
 






2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.
 






3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.
 







Homology Effector list
STY2606 , SciK, STM0277, SciK, Hcp

Effector identified
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1STU288_082601700356..1700724 [+], 369482904191putative cytoplasmic protein STY2606
2STU288_133502769936..2770421 [-], 486482905203Protein hcp1 SciK
3STU288_133602770932..2771417 [-], 486482905205putative cytoplasmic protein STM0277
4STU288_133702771722..2772207 [-], 486482905207Protein hcp1 SciK
5STU288_158503288601..3289086 [-], 486482905697hypothetical protein Hcp

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Proteins        Genes

Homology Immunity protein list
STY2607, STM0278

Immunity protein identified
#Locus tag(Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1STU288_082651700724..1701242 [+], 519482904192lipoprotein STY2607
2STU288_133552770564..2770935 [-], 372482905204putative periplasmic protein STM0278

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Proteins        Genes
N/A

Genomics & Bioinformatics Group in MML, SJTU