I. Summary
SecReT6 ID76 insolico
StrainBurkholderia pseudomallei K96243
Repliconchromosome II [Browse all T6SS(s) in this replicon]
T6SS TypeType i; subtype i3
insolico Bioinformatics investigation has been performed on this T6SS.

II. T6SS components
III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1BPSS20892827766..2828551 [+], 78653723104hypothetical protein 
2BPSS20902829283..2829711 [-], 42953723105DNA-binding protein 
3BPSS20912829708..2830487 [-], 78053723106hypothetical protein 
4BPSS20932831227..2833431 [-], 220553723107hypothetical protein  TssI
5BPSS20942833428..2836094 [-], 266753723108Clp protease ATPase  TssH
6BPSS20952836073..2837551 [-], 147953723109hypothetical protein  TssG
7BPSS20962837548..2839419 [-], 187253723110hypothetical protein  TssF
8BPSS20972839424..2839960 [-], 53753723111hypothetical protein  TssE
9BPSS20982839991..2840482 [-], 49253723112hypothetical protein  TssD
10BPSS20992840542..2842050 [-], 150953723113hypothetical protein  TssC
11BPSS21002842043..2842621 [-], 57953723114hypothetical protein  TssB
12BPSS21012842684..2843763 [-], 108053723115hypothetical protein  TssA
13BPSS21022843816..2846431 [-], 261653723116protein kinase 
14BPSS21032846642..2847574 [-], 93353723117hypothetical protein 
15BPSS21042847580..2851209 [-], 363053723118hypothetical protein  TssM
16BPSS21052851212..2852528 [-], 131753723119hypothetical protein  TssL
17BPSS21062852544..2853932 [-], 138953723120hypothetical protein  TssK
18BPSS21072853944..2854462 [-], 51953723121hypothetical protein  TssJ
19BPSS21082855102..2855503 [+], 40253723122lipoprotein 
20BPSS21092855558..2856994 [+], 143753723123FHA-family protein  Fha
21BPSS21102857037..2858941 [-], 190553723124hypothetical protein 
22BPSS21112859411..2860655 [+], 124553723125hypothetical protein 
23BPSS21132861331..2861507 [+], 17753723126hypothetical protein 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

The information on regulator interaction.

#homolog effector locus tagRegulator wayFunctionRegulate targetDescription
1BPSL2246 (PpiB)Unknown-T6SS-3 (BPSS2099/TssCIII and BPSS2098/HcpIII) expressionBpsDeltappiB strain increases in multiple components of the T6SS-3s.
(1) Burtnick MN et al. (2011). The cluster 1 type VI secretion system is a major virulence determinant in Burkholderia pseudomallei. Infect Immun. 79(4):1512-25. [PudMed:21300775] experimental
experimental This literature contains experimental investigation