I. Summary
SecReT6 ID76 insolico
StrainBurkholderia pseudomallei K96243
Repliconchromosome II [Browse all T6SS(s) in this replicon]
T6SS TypeType i; subtype i3
insolico Bioinformatics investigation has been performed on this T6SS.

II. T6SS components
III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1BPS_RS321702826777..2827034 [+], 258490684063transposase 
2BPS_RS302102827811..2828551 [+], 741490659832hypothetical protein 
3BPS_RS302152828980..2829328 [+], 349pseudogenerecombinase family protein 
4BPS_RS302202829283..2829711 [-], 429497626959DUF746 domain-containing protein 
5BPS_RS302252829708..2830541 [-], 834782684819RHS repeat protein 
6BPS_RS302302830501..2831211 [-], 711490674445hypothetical protein 
7BPS_RS30235 (tssI)2831227..2833431 [-], 2205490308264type VI secretion system tip protein VgrG 
8BPS_RS30240 (tssH)2833428..2836094 [-], 2667490664330type VI secretion system ATPase TssH 
9BPS_RS30245 (tssG)2836073..2837551 [-], 1479490675412type VI secretion system baseplate subunit TssG 
10BPS_RS30250 (tssF)2837548..2839419 [-], 1872490659822type VI secretion system baseplate subunit TssF 
11BPS_RS30255 (tssE)2839424..2839972 [-], 549497621056type VI secretion system baseplate subunit TssE 
12BPS_RS302602839991..2840482 [-], 492490295232type VI secretion system tube protein Hcp 
13BPS_RS30265 (tssC)2840542..2842050 [-], 1509490295385type VI secretion system contractile sheath large subunit 
14BPS_RS30270 (tssB)2842043..2842621 [-], 579490659820type VI secretion system contractile sheath small subunit 
15BPS_RS30275 (tssA)2842684..2843763 [-], 1080497667908type VI secretion system protein TssA 
16BPS_RS302802843816..2846431 [-], 2616499519091serine/threonine protein kinase 
17BPS_RS302852846430..2846657 [+], 228490664335hypothetical protein 
18BPS_RS30290 (tagF)2846642..2847598 [-], 9571807583205type VI secretion system-associated protein TagF 
19BPS_RS30295 (tssM)2847580..2851209 [-], 3630490659816type VI secretion system membrane subunit TssM 
20BPS_RS303002851212..2852528 [-], 1317490295223DotU family type VI secretion system protein 
21BPS_RS30305 (tssK)2852544..2853947 [-], 1404490665173type VI secretion system baseplate subunit TssK 
22BPS_RS30310 (tssJ)2853944..2854462 [-], 519490295246type VI secretion system lipoprotein TssJ 
23BPS_RS303152855102..2855503 [+], 402490294824TssQ family T6SS-associated lipoprotein 
24BPS_RS30320 (tagH)2855558..2856994 [+], 1437490690899type VI secretion system-associated FHA domain protein TagH 
25BPS_RS303252857037..2858941 [-], 1905497626978DUF3857 and transglutaminase domain-containing protein 
26BPS_RS303302858960..2859145 [+], 186490295378hypothetical protein 
27BPS_RS303352859411..2860655 [+], 1245499519093flavin-dependent oxidoreductase 
28BPS_RS303402860783..2861028 [+], 2461141013499chorismate lyase 
29BPS_RS303452860965..2861282 [+], 318497626981chorismate lyase 
30BPS_RS320302861331..2861507 [+], 177490295390hypothetical protein 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

Download FASTA format files
Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

The information on regulator interaction.

#homolog effector locus tagRegulator wayFunctionRegulate targetDescription
1BPSL2246 (PpiB)Unknown-T6SS-3 (BPSS2099/TssCIII and BPSS2098/HcpIII) expressionBpsDeltappiB strain increases in multiple components of the T6SS-3s.
(1) Burtnick MN et al. (2011). The cluster 1 type VI secretion system is a major virulence determinant in Burkholderia pseudomallei. Infect Immun. 79(4):1512-25. [PudMed:21300775] experimental
experimental This literature contains experimental investigation