I. Summary
SecReT6 ID77 insolico
StrainBurkholderia pseudomallei K96243
Repliconchromosome I [Browse all T6SS(s) in this replicon]
T6SS TypeType i; subtype i4b
insolico Bioinformatics investigation has been performed on this T6SS.

II. T6SS components
III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1BPSL30943693290..3694738 [+], 144953720703outer membrane bacteriocin efflux protein 
2BPSL30953694948..3695934 [-], 98753720704hypothetical protein 
3BPSL30963696333..3696911 [+], 57953720705bacteriophage-related peptidase 
4BPSL30973697190..3701083 [+], 389453720706hypothetical protein  TssM
5BPSL30983701080..3702069 [+], 99053720707hypothetical protein 
6BPSL30993702074..3703006 [+], 93353720708outer membrane protein  TagL
7BPSL31003703205..3704326 [-], 112253720709hypothetical protein  TssA
8BPSL3101 (clpB)3704416..3707085 [-], 267053720710protease associated ATPase ClpB  TssH
9BPSL31023707119..3708219 [-], 110153720711hypothetical protein  TssG
10BPSL31033708183..3710009 [-], 182753720712hypothetical protein  TssF
11BPSL31043710101..3710613 [-], 51353720713hypothetical protein  TssE
12BPSL31053710641..3711144 [-], 50453720714hypothetical protein  TssD
13BPSL31063711217..3712707 [-], 149153720715hypothetical protein  TssC
14BPSL31073712724..3713242 [-], 51953720716hypothetical protein  TssB
15BPSL31083713279..3713950 [-], 67253720717lipoprotein 
16BPSL31093714325..3714939 [+], 61553720718lipoprotein  TssJ
17BPSL31103715048..3716394 [+], 134753720719hypothetical protein  TssK
18BPSL31113716391..3717176 [+], 78653720720hypothetical protein  TssL
19BPSL31143718434..3719234 [+], 80153720721hypothetical protein 
20BPSL31153719241..3720311 [+], 107153720722transcriptional regulator 
21BPSL31163720594..3720857 [+], 26453720723transposase 
22BPSL31173720854..3721714 [+], 86153720724hypothetical protein 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

Homology Effector list
BTH_I0068 , BTH_I2693, BTH_I2697, BTH_I2698, BTH_I2705, BCAL0343, BTH_I3225, BTH_II0090, BTH_I3226, BTH_I3225, BTH_II0310

Effector identified
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1BPSL006776057..76497 [+], 44153717706hypothetical protein BTH_I0068
2BPSL20412438558..2441398 [-], 284153719652hypothetical protein BTH_I2693
3BPSL20462443535..2446870 [-], 333653719658hypothetical protein BTH_I2697
4BPSL20472446979..2449387 [-], 240953719659hypothetical protein BTH_I2698
5BPSL20502451504..2454302 [-], 279953719663hypothetical protein BTH_I2705
6BPSL31053710641..3711144 [-], 50453720714hypothetical protein BCAL0343
7BPSS007888921..91692 [+], 277253721116hypothetical protein BTH_I3225
8BPSS007991706..93946 [+], 224153721117hypothetical protein BTH_II0090
9BPSS12121633710..1635902 [-], 219353722235hypothetical protein BTH_I3226
10BPSS12131635964..1638741 [-], 277853722236hypothetical protein BTH_I3225
11BPSS20222732831..2733736 [+], 90653723040outer membrane protein BTH_II0310

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Proteins        Genes

Homology Immunity protein list
BTH_I0069, BTH_I2700

Immunity protein identified
#Locus tag(Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1BPSL006876484..76852 [+], 36953717707lipoprotein BTH_I0069
2BPSL2048A2449974..2450531 [-], 55853719661hypothetical protein BTH_I2700

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Proteins        Genes
(1) Burtnick MN et al. (2011). The cluster 1 type VI secretion system is a major virulence determinant in Burkholderia pseudomallei. Infect Immun. 79(4):1512-25. [PudMed:21300775] experimental
experimental This literature contains experimental investigation