I. Summary

SecReT6 ID	776
Strain	Francisella tularensis subsp. tularensis NE061598
Replicon	chromosome [Browse all T6SS(s) in this replicon]
Accession	NC_017453
Location	1773192..1798307
Comment
Function	N/A
T6SS Type	Type ii (Type FPI)
Bioinformatics investigation has been performed on this T6SS.

II. T6SS components

Component	PdpA	PdpB	IglE	VgrG	IglF	IglG	IglH	DotU	IglI
Number	1	1	1	1	1	1	1	1	1
Component	IglJ	PdpC	PdpE	IglD	IglC	IglB	IglA	PdpD
Number	1	1	1	1	1	1	1	1

III. genome coordinates of the T6SS gene cluster
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Note
1	NE061598_09885	1773192..1775654 [+], 2463	385795485	hypothetical protein	PdpA
2	NE061598_09890	1775659..1778940 [+], 3282	385795486	hypothetical protein	PdpB
3	NE061598_09895	1778930..1779307 [+], 378	385795487	lipoprotein	IglE
4	NE061598_09900	1779320..1779814 [+], 495	385795488	hypothetical protein	VgrG
5	NE061598_09905	1779807..1781549 [+], 1743	385795489	hypothetical protein	IglF
6	NE061598_09910	1781550..1782071 [+], 522	385795490	hypothetical protein	IglG
7	NE061598_09915	1782084..1783514 [+], 1431	385795491	hypothetical protein	IglH
8	NE061598_09920	1783527..1784150 [+], 624	385795492	developmental protein, putative	DotU
9	NE061598_09925	1784172..1785323 [+], 1152	385795493	hypothetical protein	IglI
10	NE061598_09930	1785289..1786062 [+], 774	385795494	hypothetical protein	IglJ
11	NE061598_09935	1786102..1790088 [+], 3987	385795495	hypothetical protein	PdpC
12	NE061598_09940	1790106..1790681 [+], 576	385795496	hypothetical protein	PdpE
13	NE061598_09945	1790688..1791884 [-], 1197	385795497	intracellular growth locus, subunit D	IglD
14	NE061598_09950	1791905..1792534 [-], 630	385795498	intracellular growth locus, subunit C	IglC
15	NE061598_09955	1792551..1794071 [-], 1521	385795499	intracellular growth locus, subunit B	IglB
16	NE061598_09960	1794085..1794639 [-], 555	385795500	intracellular growth locus, subunit A	IglA
17	NE061598_09965	1794720..1798307 [-], 3588	385795501	pathogenicity determinant protein D, pdpD	PdpD
18	NE061598_09990	1800663..1801079 [-], 417	385795502	transposase
19	NE061598_09995	1801067..1801447 [-], 381	385795503	transposase

 Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.

1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

Homology Effector list

FTT_1347 , FTL_0118

Effector identified
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Homolog
1	NE061598_09900	1779320..1779814 [+], 495	385795488	hypothetical protein	FTT_1347
2	NE061598_09925	1784172..1785323 [+], 1152	385795493	hypothetical protein	FTL_0118

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Proteins        Genes

N/A

N/A