SecReT6
SecReT6 ID787 experimental
StrainEscherichia coli RS218
Repliconchromosome [Browse all T6SS(s) in this replicon]
AccessionJN837480
Location1..23615
CommentT6SS-associated Hcp family proteins are likely to contribute to the pathogenesis of E. coli meningitis; Adhesion to and invasion of human brain microvascular endothelial cells.
Functionanti-eukaryotic;effector translocation;adherence
T6SS TypeType i; subtype i1
experimental Experimental investigation has been performed on this T6SS.

II. T6SS components
ComponentTssHTssDTssLTssITssATssBTssCTssETssF
Number321131211
ComponentTssGTssJTssKTssM
Number1112
III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1- (evfA)471..950 [-], 480356875268EvfA  TssD
2- (evfB)968..2326 [-], 1359356875269EvfB  TssA
3- (evfC)2337..5354 [-], 3018356875270EvfC  TssM
4- (evfD)5386..5865 [-], 480356875272EvfD  TssM
5- (evfF)5885..7327 [-], 1443356875273EvfF  TssA
6- (evfE)5885..6316 [-], 432356875271EvfE  TssA
7- (evfG)7332..7979 [-], 648356875274EvfG 
8- (evfH)8072..9130 [-], 1059356875275EvfH  TssH
9- (evfI)9085..9714 [-], 630356875276EvfI  TssH
10- (evfJ)9686..10834 [-], 1149356875277EvfJ  TssH
11- (evfK)10844..11608 [-], 765356875278EvfK  TssL
12- (evfL)11613..12959 [-], 1347356875279EvfL  TssK
13- (evfM)12962..13486 [-], 525356875280EvfM  TssJ
14- (evfN)13483..14091 [-], 609356875281EvfN  Fha
15- (evfO)13991..14764 [-], 774356875282EvfO  Fha
16- (evfP)14781..15830 [-], 1050356875283EvfP  TssG
17- (evfQ)15794..17635 [-], 1842356875284EvfQ  TssF
18- (evfR)17641..18066 [-], 426356875285EvfR  TssE
19- (evfS)18071..19126 [-], 1056356875286EvfS  TssC
20- (evfT)19089..19556 [-], 468356875287EvfT  TssC
21- (evfU)19579..20082 [-], 504356875288EvfU  TssB
22- (evfV)20788..21306 [+], 519356875290EvfV  TssD
23- (evfW)21527..23509 [+], 1983356875289EvfW  TssI
 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

Download FASTA format files
Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.
 






2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.
 






3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.
 







Homology Effector list
   Hcp1 (EvfV)
Homology effector (effector protein label, when available)
Homology immunity protein (immunity protein label, when available)
(1) Zhou Y et al. (2012). Hcp family proteins secreted via the type VI secretion system coordinately regulate Escherichia coli K1 interaction with human brain microvascular endothelial cells. Infect Immun. 80(3):1243-51. [PudMed:22184413] experimental
 
experimental This literature contains experimental investigation