SecReT6
SecReT6 ID789 experimental
StrainSalmonella enterica GIFU10007
Repliconchromosome [Browse all T6SS(s) in this replicon]
AccessionJF766712
Location1..38426
CommentThe T6SS was found to be associated with cytotoxicity of human epithelial cells, but not with bacterial growth or mobility in vitro; Ability to invade and infect epithelial cells
Functionanti-eukaryotic; effector translocation; virulence
T6SS TypeType i; subtype i3
experimental Experimental investigation has been performed on this T6SS.

II. T6SS components
ComponentTssHTssDTssLTssITssATssBTssCTssETssF
Number111121011
ComponentTssGTssJTssKTssM
Number1110
III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1329805067758..1063 [+], 306329805067hypothetical protein 
23298050661133..1576 [-], 444329805066hypothetical protein 
33298050651578..1838 [-], 261329805065conserved hypothetical protein 
43298050641917..4448 [-], 2532329805064Rhs-family protein 
53298050634544..4837 [-], 294329805063hypothetical protein 
63298050624856..5533 [-], 678329805062hypothetical protein 
73298050615536..9600 [-], 4065329805061Rhs-family protein  PAAR
83298050609619..10065 [-], 447329805060hypothetical protein 
932980505910089..12278 [-], 2190329805059Rhs-family protein  TssI
1032980505812641..12748 [-], 108329805058hypothetical protein 
1132980505712756..13193 [-], 438329805057hypothetical protein 
1232980505613220..13636 [-], 417329805056putative secreted protein 
1332980505513764..14225 [-], 462329805055putative secreted protein 
1432980505414210..14680 [-], 471329805054hypothetical protein 
1532980505314784..15257 [-], 474329805053putative secreted protein 
1632980505215242..15712 [-], 471329805052hypothetical protein 
1732980505115755..16522 [-], 768329805051hypothetical protein 
1832980505020620..21114 [-], 495329805050hypothetical protein 
1932980504921146..21895 [-], 750329805049putative membrane protein 
2032980504821900..23201 [-], 1302329805048putative membrane protein  TssL
2132980504723198..24541 [-], 1344329805047conserved hypothetical protein  TssK
2232980504624545..25081 [-], 537329805046putative lipoprotein  TssJ
2332980504525148..25633 [-], 486329805045Hcp-like protein  TssD
2432980504425870..26295 [-], 426329805044hypothetical protein 
2532980504326267..26668 [-], 402329805043hypothetical protein 
2632980504228253..28795 [-], 543329805042conserved hypothetical protein  TssB
2732980504128859..29149 [-], 291329805041hypothetical protein 
2832980504029152..29250 [-], 99329805040hypothetical protein 
2932980503929235..31898 [-], 2664329805039ClpB-like protein  TssH
3032980503832186..32257 [+], 72329805038hypothetical protein 
3132980503732266..33168 [+], 903329805037hypothetical protein 
3232980503633155..33979 [+], 825329805036hypothetical protein  TagJ
3332980503533976..34470 [+], 495329805035conserved hypothetical protein  TssE
3432980503434486..36369 [+], 1884329805034hypothetical protein  TssF
3532980503336366..37361 [+], 996329805033hypothetical protein  TssG
3632980503237372..37794 [+], 423329805032hypothetical protein  TssA
3732980503137794..38426 [+], 633329805031hypothetical protein  TssA
 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

Download FASTA format files
Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.
 






2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.
 






3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.
 







Homology Effector list
   SciK (AEC05357)
Homology effector (effector protein label, when available)
Homology immunity protein (immunity protein label, when available)
Regulatory element identified
PmrA
RegulatorDescriptionReference
PmrAActivatorPMID: 21487806

RcsB
RegulatorDescriptionReference
RcsBActivatorPMID: 21487806

(1) Wang M et al. (2011). Molecular characterization of a functional type VI secretion system in Salmonella enterica serovar Typhi. Curr Microbiol. 63(1):22-31. [PudMed:21487806] experimental
 
experimental This literature contains experimental investigation