SecReT6 ID794
StrainVibrio alginolyticus EPJS
Repliconchromosome [Browse all T6SS(s) in this replicon]
CommentIn-frame deletion of VEPGS_0008 resulted in obvious biofilm reduction and the complemented strain restored to the level of the wild-type strain. Besides, in-frame deletion of dotU1, VEPGS_0008 and ppkA2 abolished the swarming ability.
T6SS TypeType i; subtype i5

II. T6SS components
III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1VEPGS_0601192..452 [+], 261225382167hypothetical protein 
2VEPGS_0602482..1288 [+], 807225382168putative two-component response regulator 
3VEPGS_06031687..2148 [+], 462225382169Ser/Thr protein kinase 
4VEPGS_06042219..2416 [-], 198225382170hypothetical protein 
5VEPGS_06052445..2780 [-], 336225382171hypothetical protein 
6VEPGS_06063227..5377 [-], 2151225382172serine/threonine protein kinase 
7VEPGS_06075690..6775 [+], 1086225382173type VI secretion protein FHA-domain containing protein  Fha
8VEPGS_06086921..7685 [+], 765225791094hypothetical protein  Fha
9VEPGS_06098163..9452 [+], 1290225791095hypothetical protein  TssK
10VEPGS_06109464..10756 [+], 1293225382176hypothetical protein  TssL
11VEPGS_061110773..14291 [+], 3519225382177type VI secretion system IcmF-related protein  TssM
12VEPGS_061214273..14968 [+], 696225382178hypothetical protein 
13VEPGS_061314978..15772 [+], 795225382179serine/threonine protein phosphatase 
14VEPGS_061415765..16880 [+], 1116225382180hypothetical protein  TssA
15VEPGS_061516896..17426 [+], 531225382181hypothetical protein  TssB
16VEPGS_061617426..18919 [+], 1494225382182hypothetical protein  TssC
17VEPGS_061718984..20483 [+], 1500225382183hypothetical protein  TssC
18VEPGS_061820494..21288 [+], 795225382184hypothetical protein  TagJ
19VEPGS_061921296..21760 [+], 465225382185hypothetical protein  TssE
20VEPGS_062021757..23580 [+], 1824225382186hypothetical protein  TssF
21VEPGS_062123577..24245 [+], 669225382187hypothetical protein  TssG
22VEPGS_062224552..27119 [+], 2568225382188putative ClpA/B-type chaperone  TssH
23VEPGS_062327328..27807 [+], 480225382189uncharacterized hemolysin-coregulated protein  TssD
24VEPGS_062427857..28789 [+], 933225382190Rhs element Vgr protein  TssI
25VEPGS_062528759..29784 [+], 1026225791096hypothetical protein  TssI
26VEPGS_062630087..30926 [+], 840225382192hypothetical protein 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

Homology effector (effector protein label, when available)
Homology immunity protein (immunity protein label, when available)
Regulatory element identified
PppA (VEPGS_0613)ActivatorPMID: 23021863

(1) Sheng L et al. (2012). Connecting type VI secretion, quorum sensing, and c-di-GMP production in fish pathogen Vibrio alginolyticus through phosphatase PppA. Vet Microbiol. 162(2-4):652-62. [PudMed:23021863] experimental
(2) Liu H et al. (2012). Investigation of the roles of T6SS genes in motility, biofilm formation, and extracellular protease Asp production in Vibrio alginolyticus with modified Gateway-compatible plasmids. Lett Appl Microbiol. 55(1):73-81. [PudMed:22563695] experimental
experimental This literature contains experimental investigation