SecReT6
I. Summary
SecReT6 ID81 experimental
StrainFrancisella tularensis subsp. tularensis SCHU S4
Repliconchromosome [Browse all T6SS(s) in this replicon]
AccessionNC_006570
Location1379925..1405040
Comment
Functionanti-eukaryotic; effector translocation;virulence
T6SS TypeType ii (Type FPI)
experimental Experimental investigation has been performed on this T6SS.

II. T6SS components
ComponentPdpAPdpBIglEVgrGIglFIglGIglHDotUIglI
Number111111111
ComponentIglJPdpCPdpEIglDIglCIglBIglAPdpD
Number11111111
III. genome coordinates of the T6SS gene cluster
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductNote
1FTT_1344 (pdpA1)1379925..1382387 [+], 246356708400hypothetical protein  PdpA
2FTT_1345 (pdpB1)1382392..1385673 [+], 328256708401hypothetical protein  PdpB
3FTT_13461385663..1386040 [+], 37856708402hypothetical protein  IglE
4FTT_13471386053..1386547 [+], 49556708403hypothetical protein  VgrG
5FTT_13481386552..1388282 [+], 173156708404hypothetical protein  IglF
6FTT_13491388283..1388804 [+], 52256708405hypothetical protein  IglG
7FTT_13501388817..1390247 [+], 143156708406hypothetical protein  IglH
8FTT_13511390260..1390883 [+], 62456708407hypothetical protein  DotU
9FTT_13521390905..1392056 [+], 115256708408hypothetical protein  IglI
10FTT_13531392022..1392795 [+], 77456708409hypothetical protein  IglJ
11FTT_1354 (pdpC1)1392835..1396821 [+], 398756708410hypothetical protein  PdpC
12FTT_13551396839..1397414 [+], 57656708411hypothetical protein  PdpE
13FTT_1356c (iglD1)1397421..1398626 [-], 120656708412intracellular growth locus, subunit D  IglD
14FTT_1357c (iglC1)1398638..1399273 [-], 63656708413intracellular growth locus, subunit C  IglC
15FTT_1358c (iglB1)1399284..1400828 [-], 154556708414intracellular growth locus, subunit B  IglB
16FTT_1359c (iglA1)1400818..1401408 [-], 59156708415intracellular growth locus, subunit A  IglA
17FTT_1360c (pdpD1)1401453..1405040 [-], 358856708416hypothetical protein  PdpD
18FTT_1363c (isftu1)1407396..1408180 [-], 78556708417transposase 
 
flank Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.
1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.
 






2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.
 






3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.
 







Homology Effector list
FTT_1347 (VgrG) , FTL_0118 (IglI)

Effector identified
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  Homolog
1FTT_13471386053..1386547 [+], 49556708403hypothetical protein (VgrG)FTT_1347 (VgrG)
2FTT_13521390905..1392056 [+], 115256708408hypothetical protein (IglI)FTL_0118 (IglI)
Data from experimental literature

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Proteins        Genes
N/A
Regulatory element identified
PmrA
RegulatorDescriptionReference
PmrA (FTT_1557c)ActivatorPMID: 17452468

MglA
RegulatorDescriptionReference
MglA (FTT_1275)ActivatorPMID: 17452468

(1) Long ME et al. (2013). Disruption of Francisella tularensis Schu S4 iglI, iglJ, and pdpC genes results in attenuation for growth in human macrophages and in vivo virulence in mice, and reveals a unique phenotype for pdpC. Infect Immun. 81(3):850-61. [PudMed:23275090] experimental
(2) Broms JE et al. (2012). Unique Substrates Secreted by the Type VI Secretion System of Francisella tularensis during Intramacrophage Infection. PLoS One. 7(11):e50473. [PudMed:23185631] experimental
(3) Nano FE et al. (2007). The Francisella pathogenicity island. Ann N Y Acad Sci. 1105:122-37. [PudMed:17395722]
 
experimental This literature contains experimental investigation