I. Summary

SecReT6 ID	824
Strain	Salmonella enterica subsp. enterica serovar Typhimurium str. 08-1736
Replicon	chromosome [Browse all T6SS(s) in this replicon]
Accession	NC_021820
Location	1593099..1620481
Comment
Function	N/A
T6SS Type	Type i; subtype i3
Bioinformatics investigation has been performed on this T6SS.

II. T6SS components

Component	TssH	TssD	TssL	TssI	TssA	TssB	TssC	TssE	TssF
Number	1	2	1	1	1	1	1	1	1
Component	TssG	TssJ	TssK	TssM
Number	1	1	1	1

III. genome coordinates of the T6SS gene cluster
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Note
1	SE451236_07320 (mltD)	1588357..1589724 [-], 1368	526219197	membrane protein
2	SE451236_07325	1589796..1590551 [-], 756	526219198	hydroxyacylglutathione hydrolase
3	SE451236_07330	1590586..1591308 [+], 723	526219199	hypothetical protein
4	SE451236_07335	1591305..1591772 [-], 468	526219200	ribonuclease H
5	SE451236_07340	1591827..1592567 [+], 741	526219201	DNA polymerase III subunit epsilon
6	SE451236_07350	1593099..1594154 [-], 1056	526219202	hypothetical protein	TssA
7	SE451236_07355	1594165..1595160 [-], 996	526219203	SPI-6 associated protein	TssG
8	SE451236_07360	1595157..1597040 [-], 1884	526221961	type VI secretion protein	TssF
9	SE451236_07365	1597056..1597550 [-], 495	526219204	cytoplasmic protein	TssE
10	SE451236_07370	1597547..1598371 [-], 825	526219205	hypothetical protein	TagJ
11	SE451236_07375	1598358..1599260 [-], 903	526219206	hypothetical protein
12	SE451236_07380	1599628..1602267 [+], 2640	526219207	protein disaggregation chaperone	TssH
13	SE451236_07385	1602367..1602909 [+], 543	526219208	type VI secretion protein	TssB
14	SE451236_07390	1602933..1604426 [+], 1494	526219209	EvpB family type VI secretion protein	TssC
15	SE451236_07395	1605312..1605797 [+], 486	526219210	Hcp1 family type VI secretion system effector	TssD
16	SE451236_07400	1606102..1606587 [+], 486	526219211	hypothetical protein	STM0277 (e)
17	SE451236_07405	1606572..1606955 [+], 384	526219212	hypothetical protein	STM0278 (i)
18	SE451236_07410	1607098..1607583 [+], 486	526219213	Hcp1 family type VI secretion system effector	TssD
19	SE451236_07415	1607650..1608186 [+], 537	526219214	outer membrane lipoprotein	TssJ
20	SE451236_07420	1608190..1609533 [+], 1344	526219215	type VI secretion protein	TssK
21	SE451236_07425	1609530..1610834 [+], 1305	526219216	membrane protein	TssL
22	SE451236_07430	1610839..1611612 [+], 774	526221962	membrane protein
23	SE451236_07435	1611803..1612246 [+], 444	526219217	Shiga toxin A subunit
24	SE451236_07440	1612280..1616149 [+], 3870	526219218	membrane protein	TssM
25	SE451236_07445	1616149..1616937 [+], 789	526219219	hypothetical protein
26	SE451236_07450	1616964..1617350 [+], 387	526221963	hypothetical protein
27	SE451236_07455	1617377..1617895 [+], 519	526221964	SPI-6 associated protein
28	SE451236_07460	1618292..1620481 [+], 2190	526219220	type VI secretion protein Vgr	TssI
29	SE451236_07465	1620505..1620951 [+], 447	526219221	hypothetical protein
30	SE451236_07470	1620970..1625064 [+], 4095	526221965	type IV secretion protein Rhs	PAAR
31	SE451236_07475	1625058..1625321 [+], 264	526221966	hypothetical protein

 Genes in the 5-kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any. In the 'Note' column,if available, '(e)' denotes effector while '(i)' for immunity protein

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Proteins        Genes

V. Investigation of the genomic context of the T6SS gene cluster.

1. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the mobile genetic elements database, ACLAME.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

2. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against the virulence factor database, VFDB.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

3. BLASTp searches of the proteins encoded by T6SS gene cluster and its flanking regions against against the antibiotic resistance database, ARDB.

Job_id: Replicon RefSeq: T6SS Region Start (bp): T6SS Region End (bp): Upstream Region (kb): Downstream Region (kb):

Homology Effector list

EvpC , STM0277, EvpC, ROD_34191, STY2606

Effector identified
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Homolog
1	SE451236_07395	1605312..1605797 [+], 486	526219210	Hcp1 family type VI secretion system effector	EvpC
2	SE451236_07400	1606102..1606587 [+], 486	526219211	hypothetical protein	STM0277
3	SE451236_07410	1607098..1607583 [+], 486	526219213	Hcp1 family type VI secretion system effector	EvpC
4	SE451236_21775	4544707..4545192 [-], 486	526221496	hypothetical protein	ROD_34191
5	SE451236_18080	3773994..3774362 [+], 369	526222349	hypothetical protein	STY2606

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Proteins        Genes

Homology Immunity protein list

STM0278, STY2607

Immunity protein identified
#	Locus tag(Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Homolog
1	SE451236_07405	1606572..1606955 [+], 384	526219212	hypothetical protein	STM0278
2	SE451236_18085	3774362..3774880 [+], 519	526220918	hypothetical protein	STY2607

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Proteins        Genes

N/A